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CONTACT INFORMATION

B1318 Wisconsin Institutes for Medical Research
UW-Department of Medical Physics
Madison, WI 53705

Office telephone:(608) 262-2834

Lab MSC telephone: (608) 263-3910

Lab WIMR telephone: (608) 263-5805

Fax: (608) 262-2413

E-mail: tebarnhart@wisc.edu

CONTENTS

Positions
Memberships
Publications

PERSONAL LINKS

Todd Barnhart on PubMed

Todd E. Barnhart, Ph.D.

Todd E. Barnhart, Ph.D.

Associate Scientist, Director of PET Cyclotron Physics

Department Affiliations

Medical Physics

Education

B.S., Nuclear Engineering, University of New Mexico

B.S., Physics, Metropolitan State College of Denver, CO

M.S., Medical Physics, University of Colorado, Denver, CO

Ph.D., Medical Physics, University of Wisconsin, Madison, WI

Positions

  • 1999-2000, Researcher, Nuclear Cardiology Research, Inc., Denver, CO

  • 2000-2004, Research Assistant, Medical Physics, University of Wisconsin, Madison, WI

  • 2004-2008, Head of Cyclotron Radioisotope Production and Delivery, Wolfson Molecular Imaging Centre, University of Manchester, UK

  • 2008-Present, Associate Scientist, Director of Cyclotron Physics, Department of Medical Physics, University of Wisconsin-Madison, WI

Memberships

  • Society of Nuclear Medicine

  • Society of Radiopharmaceutical Sciences

Publications

  • Hong, H., Zhang, Y., Orbay, H., Valdovinos, H. F., Nayak, T. R., Bean, J., Theuer, C. P., Barnhart, T. E. Cai, W. Positron Emission Tomography Imaging of Tumor Angiogenesis with a 61/64 Cu-Labeled f(ab')2 Antibody Fragment. Mol Pharm 2013; 10:709-718

  • Murali, D., Barnhart, T. E., Vandehey, N. T., Christian, B. T., Nickles, R. J., Converse, A. K., Larson, J. A., Holden, J. E., Schneider, M. L., Dejesus, O. T. An efficient synthesis of dopamine transporter tracer [18F]FECNT. Appl Radiat Isot 2013; 72:128-132

  • Zhang, Y., Hong, H., Niu, G., Valdovinos, H. F., Orbay, H. K., Nayak, T. R., Chen, X. Y., Barnhart, T. E., Cai, W. Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor Expression with Cu-61-Labeled Lysine-Tagged VEGF(121). Mol Pharm 2012; 9(12):3586-3594

  • Hong, H., Zhang, Y., Nayak, T. R., Engle, J. W., Wong, H. C., Liu, B., Barnhart, T. E., Cai, W. Immuno-PET of Tissue Factor in Pancreatic Cancer. J Nucl Med 2012; 53:1748-1754

  • Hillmer, A. T., Wooten, D. W., Slesarev, M. S., Ahlers, E. O., Barnhart, T. E., Murali, D., Schneider, M. L., Mukherjee, J., Christian, B. T. PET Imaging of α54β2* Nicotinic Acetylcholine Receptors: Quantitative Analysis of 18F-Nifene Kinetics in the Nonhuman Primate. J Nucl Med 2012; 53(9):1471-1480

  • Hong, H., Zhang, Y., Severin, G. W., Yang, Y., Engle, J. W., Niu, G., Nickles, R. J. Chen, X., Leigh, B. R., Barnhart, T. E., Cai, W. Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody Dual-Labeled with 89Zr and IRDye 800CW. Mol Pharm 2012; 9:2339-2349

  • Zhang, Y., Hong, H., Severin, G. W., Engle, J. W., Yang, Y., Goel, S., Nathanson, A. J., Liu, G., Nickles, R. J., Leigh, B. R., Barnhart, T. E., Cai, W. ImmunoPET and near-infrared fluorescence imaging of CD105 expression using a monoclonal antibody dual-labeled with 89Z and IRDye 800CW. Am J Transl Res 2012; 4(3):333-346

  • Yang, Y., Niu, Y., Hong, H., Wu, H., Zhang, Y., Engle, J. W., Barnhart, T. E., Cai, J., Cai, W.. Radiolabeled c-AApeptides: a new class of tracers for positron emission tomograph. Chem Comm 2012; 48:7850-7852

  • Severin, G. W., Engle, J. W., Valdovinos, H. F., Barnhart, T. E., Nickles, R. J. Cyclotron produced 44gSc from natural calcium. Appl Rad Isot 2012; 70(8):1526-1530

  • Engle, J. W., Hong, H., Zhang, Y., Valdovinos, H. F., Myklejord, D. V., Barnhart, T. E., Theuer, C. P., Nickles, R. J., Cai, W. Positron emission tomography imaging of tumor angiogenesis with a 66Ga-labeled monoclonal antibody. Mol Pham 2012; 9(5):1441-1448

  • Joers, V., Seneczk, K, Goecks, N. C., Kamp, T. J., Hacker, T. A., Brunner, K. G., Engle, J. W., Barnhart, T. E., Nickles, R. J., Holden, J. E., Emborg, M. E. Nonuniform Cardiac Denervation Observed by 11C-meta-Hydroxyephedrine PET in 6-OHDA-Treated Monkeys. PLoS ONE 2012(4): e35371

  • Engle, J. W., Lopez-Rodriguez, V., Gaspar-Carcamo, R. E., Valdovinos, H. F., Valle-Gonzalez, M., Trejo-Ballado, F., Severin, G. W., Barnhart, T. E., Nickles, R. J., Avila-Rodriguez, M. A. Very high specific activity 66/68Ga from zinc targets for PET. Appl Radiat Isot 2012; 70(8):1792-1796

  • Wooten, D. W., Hillmer A. T., Moirano, J. M., Ahlers, E. O., Slesarev, M., Barnhart, T. E., Mukherjee, J., Schneider, M. L., Christian, B. T. Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [18F]mefway in the nonhuman primate. J Cereb. Blood Flow Metab 2012; 32(8):1546-1558

  • Hong, H., Zhang, Y., Engle, J. W., Nayak, T. R., Theuer, C. P., Nickles, R. J., Barnhart, T. E., Cai, W. In-vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-graphene. Biomaterials 2012; 33(16):4147-56

  • Hong, H., Yang, K., Zhang, Y., Engle, J. W., Feng, L., Yang, Y., Nayak, T. R., Goel, S., Bean, J., Theuer, C. P., Barnhart, T. E., Liu, Z., Cai, W. In-Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene. ACS Nano 2012; 6(3):2361-2370

  • Engle, J. W., Severin, G. W., Barnhart, T. E., Knutson, L. D., Nickles, R. J. Cross sections of the 36Ar(d,α)34mCl, 40Ar(d,α)38Cl, and 40Ar(d,p)41Ar nuclear reactions below 8.4 MeV. Appl Radiat Isot 2012; 70(2):355-359

  • Zhang, Y., Hong, H., Engle, J. W., Yang, Y., Theuer, C. P., Barnhart, T. E., Cai, W. Positron Emission Tomography and Optical Imaging of Tumor CD105 Expression with a Dual-Labeled Monoclonal Antibody. Mol Pharm 2012; 9(3):645-653

  • Xiao, Y., Hong, H., Javadi, A., Engle, J. W., Xu, W., Yang, Y., Zhang, Y., Barnhart, T. E., Cai, W., Gong, S. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials 2012; 33(11):3071-3082

  • Zhang, Y., Hong, H., Engle, J.W., Yang, Y, Barnhart, T.E., Cai, W. Positron emission tomography and near-infrared fluorescence imaging of vascular endothelial growth factor with dual-labeled bevacizumab. Am J of Nuc Med and Mol Imag 2012; 1:1-13

  • Hong, H., Severin, G. W., Yang, Y., Engle, J. W., Zhang, Y., Barnhart, T. E., Liu, G., Leigh, B. R., Nickles, R. J., Cai, W. Positron emission tomography imaging of CD105 expression with 89Zr-Df-TRC105. Eur J of Nucl Med and Mol Imag 2012; 39:138-148

  • Zhang, Y., Hong, H., Engle, J. W., Bean, J., Yang. Y., Leigh, B. R., Barnhart, T. E., Cai, W. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled antibody: NOTA is superior to DOTA. PLoS ONE, 2011, 6, e28005

  • Hong, H., Benink, H. A., Zhang, Y., Yang, Y., Uyeda, H. T., Engle, J. W., Severin, G. W., McDougall, M. G., Barnhart, T. E., Klaubert, D. H., Nickles, R. J., Fan, F., Cai, W. HaloTag: a novel reporter gene for positron emission tomography. Am J Transl Res. 2011; 3(4):392-403

  • Severin, G.W., Engle J.W., Barnhart, T.E., Nickles, R.J. 89Zr Radiochemistry for Positron Emission Tomography. Med Chem. 2011; 7(5):389-394

  • Engle, J. W., Barnhart, T. E., Severin, G. W., Nickles, R. J. The unrealized potential of 34mCl for radiopharmaceutical research with PET. Current Radiopharm 2011; 4(2):102-108

  • Wooten, D., Hillmer, A., Murali, D., Barnhart, T. E., Schneider, M. L., Mukherjee, J., Christian, B. T. An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate. Nucl Med Biol 2011; 38(7):925-932

  • Hillmer, A. T., Wooten, D. W., Moirano J. M., Slesarev, M., Barnhart T. E., Engle J. W., Nickles, R. J., Murali, D., Schneider, M. L., Mukherjee, J., Christian, B. T. Specific α4β2 nicotinic acetylcholine receptor binding of [18F]nifene in the rhesus monkey. Synapse 2011; 65(5):1309-1318

  • Bartlett, R. M., Murali, D., Nickles, R. J., Barnhart, T. E., Holden, J. E., DeJesus, O. T., Assessment of Fetal Brain Uptake of Paraquat In Utero Using In Vivo PET/CT Imaging. Tox Sci 2011; 122(2):551-558

  • Hong, H., Yang, Y., Zhang, Y., Engle, J. W., Barnhart, T. E., Nickles, R. J., Leigh, B. R., Cai, W., Positron emission tomography imaging of CD105 expression during tumor angiogenesis. Eur J of Nucl Med 2011; 38(7):592-600

  • Wooten, D. W., Moraino, J. D., Hillmer, A. T., Engle, J. W., DeJesus, O. T., Murali, D., Barnhart, T. E., Nickles, R. J., Davidson, R. J., Schneider, M. L. Mukherjee, J., Christian, B. T. In-Vivo Kinetics of [18F]Mefway: A Comparison With [11C]WAY100635 and [18F]MPPF in the Nonhuman Primate. Synapse 2011; 55(7):592-600

  • Converse, A. K. Larsen, E. C., Engle, J. W., Barnhart, T. E., Nickles, R. J., Duncan, I. D., 11C-(R)-PK11195 PET Imaging of Microglial Activation and Response to Minocycline in Zymosan-Treated Rats. J Nucl Med 2011; 52(2):257-262

  • Engle J. W., Barnhart, T. E., DeJesus, O. T., Nickles, R. J. Production of 34mCl and 38Cl via the (d,α) reaction on 36Ar and natAr gas at 8 4 MeV. Appl Rad and Isot 2011 69(1): 75-79.

  • Bartlett, R. M., DeJesus O. T., Barnhart, T. E., Nickles, R. J., Christian B. T., Graner, J., and Holden, J. E., Fetal Dopamine Receptor Characteristics Assessed in Utero, J Cereb. Blood Flow Metab 2010; 30:1437-1440

  • Bartlett, R. M. Nickles, R. J., Barnhart, T. E., Christian B.T., Holden J. E., and DeJesus O. T. Fetal Dose Estimates for 18F-Fluoro-L-Thymidine Using a Pregnant Monkey Model. J Nucl Med 2010; 51(2):288-292.

  • Bartlett R. M., Holden J. E, Nickles R. J., Murali, D., Barbee D. L., Barnhart T. E., Christian B. T., DeJesus, O. T. Paraquat is excluded by the blood brain barrier in rhesus macaque: An In-Vivo PET study. Brain Res 2009; 1259:74-79

  • Kasyutich, V. L., McMahon, A., Barnhart, T., Martin, P. A. On-line monitoring of cyclotron target-gas output by means of tunable lead salt diode laser absorption spectroscopy. Appl Phy B-Lasers and Optics 2008; 93(2-3):701-711

  • Schneider, M. L., Moore, C. F., Barnhart, T. E., Larson, J. A., DeJesus, O. T., Mukherjee, J., Nickles, R. J., Converse, A. K., Roberts, A. D., Kraemer, G. W. Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys. Alcohol Clin Exp Res 2005; 29(9):1685-1697

  • DeJesus, O. T., Flores, L. G., Murali, D., Converse, A. K., Bartlett, R. M., Barnhart, T. E., Oakes T. R., Nickles, R. J. Aromatic l-amino acid decarboxylase turnover in vivo in rhesus macaque striatum: A microPET study. Brain Res. 2005 1054(1): 55-60

  • Barnhart, T. E., Dabbs, K. A., Converse, A. K., Schueller, M. J., Nickles, R. J., Roberts, A. D. Production of the Short-Lived PET Flow Tracer [17F]CH3F using 11 MeV Protons or 6MeV deuterons. Appl Rad Isot 2005; 62(4):525-532

  • Ferrarelli, F., Haraldsson, H. M., Barnhart, T. E., Roberts, A. D., Oakes, T. R., Massimini, M., Stone, C. K., Kalin, N. H., Tononi, G. A [17F]-fluoromethane PET/TMS study of effective connectivity. Brain Res 2004; 64:103-113

  • Nickles, R. J., Barnhart, T. E., Avila-Rodrigues, M. A., Converse, A. K., Sundaresan, R., Nye, J. A., Dick, D. W., Roberts, A. D. Production of 16N for instrument calibration. Radiochimica Acta 2004; 92:229-232

  • Roberts, A. D., Moore, C. F., Barnhart, T. E., DeJesus, O. T., Larson, J. A., Mukherjee, J., Nickles, R. J., Schueller, M. J., Shelton, S. E., Schneider., M. L. Prenatal stress, moderate fetal alcohol exposure, and dopamine system function in rhesus monkeys. Neurotoxicology and Teratology 2004; 26(2):169-343.

  • Converse, A. K., Barnhart, T. E., Dabbs, K. A., DeJesus, O. T., Larson, J. A., Nickles, R. J. Schneider, M. L., Roberts, A. D. Simultaneous PET Imaging of rCBF and Neurochemical Function. J of Neurosci Meth 2004;132:199-208.

  • Barnhart, T. E., Converse, A. K., Dabbs, K. A., Nickles, R. J., Roberts, A. D. Water Cooled Grid Support System for High Power Irradiation of Thin Target Windows. Appl Rad Isot 2003; 58(1):21-26.

  • Johnson, T. K., Barnhart. T. An alternative to Monte Carlo in determining release criteria for patients administered radioactive material, Health Physics 1999; 77(6):724-726

  • Haney, J. H., Barnhart, T. E., Zaidins, C. S. Extraction of neutron spectral information from Bonner-Sphere data, Nucl Inst Meth A 1999; 431(3):551-555



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