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M. Elizabeth Meyerand, Ph.D.

M. Elizabeth Meyerand, Ph.D.

Chair, Department of Biomedical Engineering

Professor: Departments of Medical Physics and Biomedical Engineering

Department Affiliations

Medical Physics

Biomedical Engineering

Radiology

Education

B.S., Molecular Biophysics & Biochemistry, Yale University New Haven CT

M.S, Biomedical Engineering, University of North Carolina, Chapel Hill NC

Ph.D., Biophysics, Medical College of Wisconsin, Milwaukee,WI

Research Interest

Principal Investigator: Applied Neuro MRI Lab

http://www.neurofmri.bme.wisc.edu/

Imaging Brain Function and Structure Using MRI

My research lab focuses on the the field of magnetic resonance imaging (MRI) of the human brain. Our goal is the development and application of new MR methods to visualize the structure and function of the brain and to translate these methods to the hospital for clinical diagnosis. One of the areas upon which we concentrate our research is functional MRI (fMRI). FMRI allows us to visualize both the temporal and spatial patterns of brain activity in response to different stimuli. We are particularly interested in the development of new analysis methods to improve our understanding of brain function.

In addition to analyzing brain activation, we are also developing techniques to explore brain connectivity using diffusion tensor imaging (DTI) and the concept of effective connectivity. As implemented in MRI, DTI is a noninvasive imaging technique that can be used to probe the intrinsic diffusion characteristics of tissue. Brain tissue where diffusion is restricted or anisotropic (white matter) will appear at a different level of brightness in a DTI image than tissue with isotropic diffusion (gray matter). As a result, DTI is extremely useful for providing exquisitely detailed in vivo maps of major white matter fiber pathways. Techniques for diffusion imaging are evolving rapidly. Diffusion MRI research has been shown to have important applications, especially in stroke, the effects of tumors, degenerative diseases and brain injury.

Effective connectivity describes the integration within and between functionally specialized areas of the brain. Regions of the brain are located using fMRI. Integration of these regions is achieved through the information gained from DTI. We explore effective connectivity in a variety of large-scale neurocognitive networks using different mathematical modeling techniques, including dynamic causal modeling. Our clinical emphasis is in Parkinson's disease, patients with schizophrenia and patients with balance disorders.

Publications

  • K. M. McMillan, A. R. Laird, S. T. Witt, and M. E. Meyerand, "Self-Paced Working Memory: Validation of Verbal Variations of the n-Back Paradigm," Brain Res. 1139, 133-142 (2007). [PMID: 17280644]
  • K. M. McMillan, B. P. Rogers, C. G. Koay, A. R. Laird, R. R. Price, and M. E. Meyerand, "An Objective Method for Combining Multi-Parametric MRI Datasets to Characterize Malignant Tumors," Med.Phys. 34, 1053-1061 (2007). [PMID: 17441252]
  • S. C. Johnson, T. W. Schmitz, C. H. Moritz, M. E. Meyerand, H. A. Rowley, A. L. Alexander, K. W. Hansen, C. E. Gleason, C. M. Carlsson, M. L. Ries, S. Asthana, K. Chen, E. M. Reiman, and G. E. Alexander, "Activation of Brain Regions Vulnerable to Alzheimer's Disease: The Effect of Mild Cognitive Impairment," Neurobiol.Aging. 27, 1604-1612 (2006). [PMID: 16226349]
  • K. M. McMillan, B. P. Rogers, A. S. Field, A. R. Laird, J. P. Fine, and M. E. Meyerand, "Physiologic Characterisation of Glioblastoma Multiforme using MRI-Based Hypoxia Mapping, Chemical Shift Imaging, Perfusion and Diffusion Maps," J.Clin.Neurosci. 13, 811-817 (2006). [PMID: 16997706]
  • C. G. Koay, J. D. Carew, A. L. Alexander, P. J. Basser, and M. E. Meyerand, "Investigation of Anomalous Estimates of Tensor-Derived Quantities in Diffusion Tensor Imaging," Magn.Reson.Med. 55, 930-936 (2006). [PMID: 16526013]
  • D. G. Blankenbaker, V. M. Haughton, B. P. Rogers, M. E. Meyerand, and J. P. Fine, "Axial Rotation of the Lumbar Spinal Motion Segments Correlated with Concordant Pain on Discography: A Preliminary Study," AJR Am.J.Roentgenol. 186, 795-799 (2006). [PMID: 16498109]
  • B. Rogers, S. Wiese, D. Blankenbaker, E. Meyerand, and V. Haughton, "Accuracy of an Automated Method to Measure Rotations of Vertebrae from Computerized Tomography Data," Spine. 30, 694-696 (2005). [PMID: 15770187]
  • C. H. Moritz, J. D. Carew, A. B. McMillan, and M. E. Meyerand, "Independent Component Analysis Applied to Self-Paced Functional MR Imaging Paradigms," Neuroimage. 25, 181-192 (2005). [PMID: 15734354]
  • C. H. Moritz, S. C. Johnson, K. M. McMillan, V. M. Haughton, and M. E. Meyerand, "Functional MRI Neuroanatomic Correlates of the Hooper Visual Organization Test," J.Int.Neuropsychol.Soc. 10, 939-947 (2004). [PMID: 15803557]
  • A. B. McMillan, B. P. Hermann, S. C. Johnson, R. R. Hansen, M. Seidenberg, and M. E. Meyerand, "Voxel-Based Morphometry of Unilateral Temporal Lobe Epilepsy Reveals Abnormalities in Cerebral White Matter," Neuroimage. 23, 167-174 (2004). [PMID: 15325363]
  • B. P. Rogers, J. D. Carew, and M. E. Meyerand, "Hemispheric Asymmetry in Supplementary Motor Area Connectivity during Unilateral Finger Movements," Neuroimage. 22, 855-859 (2004). [PMID: 15193615]
  • A. R. Laird, B. P. Rogers, and M. E. Meyerand, "Comparison of Fourier and Wavelet Resampling Methods," Magn.Reson.Med. 51, 418-422 (2004). [PMID: 14755671]
  • J. Sailor, M. E. Meyerand, C. H. Moritz, J. Fine, L. Nelson, B. Badie, and V. M. Haughton, "Supplementary Motor Area Activation in Patients with Frontal Lobe Tumors and Arteriovenous Malformations," AJNR Am.J.Neuroradiol. 24, 1837-1842 (2003). [PMID: 14561613]
  • M. Lazar, D. M. Weinstein, J. S. Tsuruda, K. M. Hasan, K. Arfanakis, M. E. Meyerand, B. Badie, H. A. Rowley, V. Haughton, A. Field, and A. L. Alexander, "White Matter Tractography using Diffusion Tensor Deflection," Hum.Brain Mapp. 18, 306-321 (2003). [PMID: 12632468]
  • J. D. Carew, G. Wahba, X. Xie, E. V. Nordheim, and M. E. Meyerand, "Optimal Spline Smoothing of fMRI Time Series by Generalized Cross-Validation," Neuroimage. 18, 950-961 (2003). [PMID: 12725770]
  • M. Quigley, D. Cordes, P. Turski, C. Moritz, V. Haughton, R. Seth, and M. E. Meyerand, "Role of the Corpus Callosum in Functional Connectivity," AJNR Am.J.Neuroradiol. 24, 208-212 (2003). [PMID: 12591635]
  • C. H. Moritz, B. P. Rogers, and M. E. Meyerand, "Power Spectrum Ranked Independent Component Analysis of a Periodic fMRI Complex Motor Paradigm," Hum.Brain Mapp. 18, 111-122 (2003). [PMID: 12518291]
  • H. A. Jaradat, W. A. Tome, T. R. McNutt, and M. E. Meyerand, "On the Incorporation of Multi-Modality Image Registration into the Radiotherapy Treatment Planning Process," Technol.Cancer.Res.Treat. 2, 1-12 (2003). [PMID: 12625748]
  • B. P. Rogers, V. M. Haughton, K. Arfanakis, and M. E. Meyerand, "Application of Image Registration to Measurement of Intervertebral Rotation in the Lumbar Spine," Magn.Reson.Med. 48, 1072-1075 (2002). [PMID: 12465120]
  • J. F. Dunn, J. A. O'Hara, Y. Zaim-Wadghiri, H. Lei, M. E. Meyerand, O. Y. Grinberg, H. Hou, P. J. Hoopes, E. Demidenko, and H. M. Swartz, "Changes in Oxygenation of Intracranial Tumors with Carbogen: A BOLD MRI and EPR Oximetry Study," J.Magn.Reson.Imaging. 16, 511-521 (2002). [PMID: 12412027]
  • L. Nelson, S. Lapsiwala, V. M. Haughton, J. Noyes, A. H. Sadrzadeh, C. H. Moritz, M. E. Meyerand, and B. Badie, "Preoperative Mapping of the Supplementary Motor Area in Patients Harboring Tumors in the Medial Frontal Lobe," J.Neurosurg. 97, 1108-1114 (2002). [PMID: 12450033]
  • B. P. Witwer, R. Moftakhar, K. M. Hasan, P. Deshmukh, V. Haughton, A. Field, K. Arfanakis, J. Noyes, C. H. Moritz, M. E. Meyerand, H. A. Rowley, A. L. Alexander, and B. Badie, "Diffusion-Tensor Imaging of White Matter Tracts in Patients with Cerebral Neoplasm," J.Neurosurg. 97, 568-575 (2002). [PMID: 12296640]
  • K. Arfanakis, B. P. Hermann, B. P. Rogers, J. D. Carew, M. Seidenberg, and M. E. Meyerand, "Diffusion Tensor MRI in Temporal Lobe Epilepsy," Magn.Reson.Imaging. 20, 511-519 (2002). [PMID: 12413596]
  • V. M. Haughton, B. Rogers, M. E. Meyerand, and D. K. Resnick, "Measuring the Axial Rotation of Lumbar Vertebrae in Vivo with MR Imaging," AJNR Am.J.Neuroradiol. 23, 1110-1116 (2002). [PMID: 12169466]
  • A. R. Laird, B. P. Rogers, J. D. Carew, K. Arfanakis, C. H. Moritz, and M. E. Meyerand, "Characterizing Instantaneous Phase Relationships in Whole-Brain fMRI Activation Data," Hum.Brain Mapp. 16, 71-80 (2002). [PMID: 11954057]
  • K. Arfanakis, V. M. Haughton, J. D. Carew, B. P. Rogers, R. J. Dempsey, and M. E. Meyerand, "Diffusion Tensor MR Imaging in Diffuse Axonal Injury," AJNR Am.J.Neuroradiol. 23, 794-802 (2002). [PMID: 12006280]
  • G. E. Nybakken, M. A. Quigley, C. H. Moritz, D. Cordes, V. M. Haughton, and M. E. Meyerand, "Test-Retest Precision of Functional Magnetic Resonance Imaging Processed with Independent Component Analysis," Neuroradiology. 44, 403-406 (2002). [PMID: 12012124]
  • E. Nattie, L. Aihua, E. Meyerand, J.F. Dunn, “VentralMedulla pHi Measured in Vivo by P NMR is not Regulated During Hypercapnia in Anesthetized Rat,” Respiratory Phys. & Neurobio. 130, 139-149 (2002). [PMID: 12380004]
  • K. Arfanakis, D. Cordes, V. M. Haughton, J. D. Carew, and M. E. Meyerand, "Independent Component Analysis Applied to Diffusion Tensor MRI," Magn.Reson.Med. 47, 354-363 (2002). [PMID: 11810680]
  • M. A. Quigley, V. M. Haughton, J. Carew, D. Cordes, C. H. Moritz, and M. E. Meyerand, "Comparison of Independent Component Analysis and Conventional Hypothesis-Driven Analysis for Clinical Functional MR Image Processing," AJNR Am.J.Neuroradiol. 23, 49-58 (2002). [PMID: 11827875]
  • J. H. Brannen, B. Badie, C. H. Moritz, M. Quigley, M. E. Meyerand, and V. M. Haughton, "Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area," AJNR Am.J.Neuroradiol. 22, 1711-1718 (2001). [PMID: 11673166]
  • D. Cordes, V. M. Haughton, K. Arfanakis, J. D. Carew, P. A. Turski, C. H. Moritz, M. A. Quigley, and M. E. Meyerand, "Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in "Resting-State" Data," AJNR Am.J.Neuroradiol. 22, 1326-1333 (2001). [PMID: 11498421]
  • M. Quigley, D. Cordes, G. Wendt, P. Turski, C. Moritz, V. Haughton, and M. E. Meyerand, "Effect of Focal and Nonfocal Cerebral Lesions on Functional Connectivity Studied with MR Imaging," AJNR Am.J.Neuroradiol. 22, 294-300 (2001). [PMID: 11156772]
  • D. Cordes, V. M. Haughton, K. Arfanakis, G. J. Wendt, P. A. Turski, C. H. Moritz, M. A. Quigley, and M. E. Meyerand, "Mapping Functionally Related Regions of Brain with Functional Connectivity MR Imaging," AJNR Am.J.Neuroradiol. 21, 1636-1644 (2000). [PMID: 11039342]
  • C. H. Moritz, V. M. Haughton, D. Cordes, M. Quigley, and M. E. Meyerand, "Whole-Brain Functional MR Imaging Activation from a Finger-Tapping Task Examined with Independent Component Analysis," AJNR Am.J.Neuroradiol. 21, 1629-1635 (2000). [PMID: 11039341]
  • K. Arfanakis, D. Cordes, V. M. Haughton, C. H. Moritz, M. A. Quigley, and M. E. Meyerand, "Combining Independent Component Analysis and Correlation Analysis to Probe Interregional Connectivity in fMRI Task Activation Datasets," Magn.Reson.Imaging. 18, 921-930 (2000). [PMID: 11121694]
  • T. Stein, C. Moritz, M. Quigley, D. Cordes, V. Haughton, and E. Meyerand, "Functional Connectivity in the Thalamus and Hippocampus Studied with Functional MR Imaging," AJNR Am.J.Neuroradiol. 21, 1397-1401 (2000). [PMID: 11003270]
  • C. H. Moritz, M. E. Meyerand, D. Cordes, and V. M. Haughton, "Functional MR Imaging Activation After Finger Tapping has a Shorter Duration in the Basal Ganglia than in the Sensorimotor Cortex," AJNR Am.J.Neuroradiol. 21, 1228-1234 (2000). [PMID: 10954273]
  • V. M. Haughton, P. A. Turski, B. Meyerand, G. Wendt, C. H. Moritz, and J. Ulmer, "The Clinical Applications of Functional MR Imaging," Neuroimaging Clin.N.Am. 9, 285-293 (1999). [PMID: 10318715]
  • J. F. Dunn, Y. Z. Wadghiri, and M. E. Meyerand, "Regional Heterogeneity in the Brain's Response to Hypoxia Measured using BOLD MR Imaging," Magn.Reson.Med. 41, 850-854 (1999). [PMID: 10332864]
  • M. E. Meyerand, J. M. Pipas, A. Mamourian, T. D. Tosteson, and J. F. Dunn, "Classification of Biopsy-Confirmed Brain Tumors using Single-Voxel MR Spectroscopy," AJNR Am.J.Neuroradiol. 20, 117-123 (1999). [PMID: 9974066]
  • M. E. Meyerand, C. H. Moritz, and E. C. Wong, "Single-Shot, Motion Insensitive Cardiac Imaging on a Standard Clinical System," Magn.Reson.Med. 40, 930-933 (1998). [PMID: 9840839]
  • M. E. Meyerand, Y. Cremillieux, Y. Z. Wadghiri, A. Azzawi, P. J. Hoopes, and J. F. Dunn, "In Vivo Gradient Echo Microimaging of Rodent Spinal Cord at 7 T," Magn.Reson.Med. 40, 789-791 (1998). [PMID: 9797164]
  • M. E. Meyerand, and E. C. Wong, "A Time Encoding Method for Single-Shot Imaging," Magn.Reson.Med. 34, 618-622 (1995). [PMID: 8524031]
  • M. Gill, S. L. Miller, D. Evans, J. H. Scatliff, M. E. Meyerand, S. K. Powers, and L. Kwock, "Magnetic Resonance Imaging and Spectroscopy of Small Ring-Enhancing Lesions using a Rat Glioma Model," Invest.Radiol. 29, 301-306 (1994). [PMID: 8175304]
  • Children with new-onset epilepsy exhibit diffusion abnormalities in cerebral white matter in the absence of volumetric differences. Hutchinson E, Pulsipher D, Dabbs K, Y Gutierrez AM, Sheth R, Jones J, Seidenberg M, Meyerand E, Hermann B. Epilepsy Res. 2009 Dec 29. [Epub ahead of print] [PMID: 20044239]
  • The Effects of Computational Method, Data Modeling, and TR on Effective Connectivity Results. Witt ST, Meyerand ME. Brain Imaging Behav. 2009 Jun;3(2):220-231. [PMID: 19714255]
  • Functional neuroimaging correlates of finger-tapping task variations: an ALE meta-analysis. Witt ST, Laird AR, Meyerand ME. Neuroimage. 2008 Aug 1;42(1):343-56. Epub 2008 Apr 16. [PMID: 18511305]
  • Molecular and functional imaging in radiation oncology. Jeraj R, Meyerand ME. Cancer Treat Res. 2008;139:63-95. Review. [PMID: 18236712]
  • Creating physical 3D stereolithograph models of brain and skull. Kelley DJ, Farhoud M, Meyerand ME, Nelson DL, Ramirez LF, Dempsey RJ, Wolf AJ, Alexander AL, Davidson RJ. PLoS One. 2007 Oct 31;2(10):e1119. PMID: 17971879


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