Departments of Medical Physics and Radiology and the Paul Carbone Comprehensive Cancer Center
The Paul Carbone Cancer Research Imaging Center, along with the Departments of Radiology and Medical Physics feature a Varian 4.7T horizontal bore magnetic resonance imaging/spectroscopy system. This system provides the capability to scan samples up to 600 grams in size, or with a diameter of 72 mm or less, with an in-plane resolution on the order of 50 microns. The imaging laboratory is equipped with an anesthesia system and physiologic monitoring that allows for image gating. MRI is totally non-invasive (there is no ionizing radiation) and scans can be repeated multipletimes to track disease progression ortreatment effectiveness.
A C-13 polarizer (Hypersense, Oxford Instruments) is available to polarize a 4mg C-13-containing sample dissolved in 100-200 microliters of solvent to levels of 20% to 30% in 2-4 hours. Dissolution in water or methanol produces a liquid volume of 4-5 ml, which can be studied in vitro or in vivo. This provides gains in sensitivity for a variety of biologically-relevant samples, including metabolites and vitamins.
Scheduling Information
All users must first schedule a planning session to discuss how our services can best meet your needs. Please contact Beth Rauch at brauch@wisc.edu or 608-263-1109 to do so.
Fee Information
*Sequence development and start-up for new project are free of charge (up to 10 hours) After that, the following applies:
- UWCCC Members: $220/hour
- Non UWCCC Members: $275/hour
- Commercial Users (non UW): $408/hour
- Anesthesia & Supply Charge: $5/scan
- Data Analysis& Technical Devolpment Time: $50-125/hour, Contact the Image Analysis Core for more information
** Overnight scans will be charged for 2 hours worth of time (plus setup time).
Potential Uses of the System
- Food Science Industry
- Botany and Agricultural Sciences
- Ex-vivo and In-vivo Imaging
- Molecular imaging
- Track stem cells in vivo
- Macrophage infiltration
- Pin-point brain ischemia
- Tracking neural pathways
- Image Anatomy
- Visual airways in the lung
- Monitor drug effects
- Cardiac & blood vessel MRI
- Muscles, tendons & cartilage imaging
- Kidney and liver imaging
- Transgenic Animals
- Oncology
- Phenotyping
- Atherosclerosis
- Neuological disorders
Who could benefit from the Pre-Clinical MRI Center?
Our system is very flexible and can be useful for a multitude of disciplines. These include the pharmaceutical and food industry, veterinary, psychology, biomedical sciences, immunology, materials development, and more. Usefulness is only limited by the size of the magnet’s bore. Contact us for a free consultation at brauch@wisc.edu or 608-263-1109.
