Medical Physics Department, University of Wisconsin

The Paul Carbone Cancer Research Imaging Center, along with the Departments of Radiology and Medical Physics feature a Varian 4.7T horizontal bore magnetic resonance imaging/spectroscopy system. This system provides the capability to scan samples up to 600 grams in size, or with a diameter of 72 mm or less, with an in-plane resolution on the order of 50 microns. The imaging laboratory is equipped with an anesthesia system and physiologic monitoring that allows for image gating. MRI is totally non-invasive (there is no ionizing radiation) and scans can be repeated multiple times to track disease progression or treatment effectiveness.

A C-13 polarizer (Hypersense, Oxford Instruments) is available to polarize a 4mg C-13-containing sample dissolved in 100-200 microliters of solvent to levels of 20% to 30% in 2-4 hours. Dissolution in water or methanol produces a liquid volume of 4-5 ml, which can be studied in vitro or in vivo. This provides gains in sensitivity for a variety of biologically-relevant samples, including metabolites and vitamins.

Scheduling and Fee Information:

All users must first schedule a planning session to discuss how our services can best meet your needs.

Please contact Beth Rauch at brauch@wisc.edu or 608-263-1109 to do so.

Fee Structure:

*the first 10 hours of start-up for new projects are free of charge.

UWCCC Members: $220/hour

Non UWCCC Members: $375/hour

Commercial Users (non UW): $556/hour

Anesthesia & Supply Charge: $5/scan

Data Analysis: $30/hour

Technical Development Time: $40/hour


Pre-Clinical MRI LAB Departments of Medical Physics and Radiology and the Paul Carbone Comprehensive Cancer Center
	The Paul Carbone Cancer Research Imaging Center, along with the Departments of Radiology and Medical Physics feature a Varian 4.7T horizontal bore magnetic resonance imaging/spectroscopy system. This system provides the capability to scan samples up to 600 grams in size, or with a diameter of 72 mm or less, with an in-plane resolution on the order of 50 microns. The imaging laboratory is equipped with an anesthesia system and physiologic monitoring that allows for image gating. MRI is totally non-invasive (there is no ionizing radiation) and scans can be repeated multiple times to track disease progression or treatment effectiveness. A C-13 polarizer (Hypersense, Oxford Instruments) is available to polarize a 4mg C-13-containing sample dissolved in 100-200 microliters of solvent to levels of 20% to 30% in 2-4 hours. Dissolution in water or methanol produces a liquid volume of 4-5 ml, which can be studied in vitro or in vivo. This provides gains in sensitivity for a variety of biologically-relevant samples, including metabolites and vitamins. Scheduling and Fee Information: All users must first schedule a planning session to discuss how our services can best meet your needs. Please contact Beth Rauch at brauch@wisc.edu or 608-263-1109 to do so. Fee Structure: *the first 10 hours of start-up for new projects are free of charge. UWCCC Members: $220/hour Non UWCCC Members: $375/hour Commercial Users (non UW): $556/hour Anesthesia & Supply Charge: $5/scan Data Analysis: $30/hour Technical Development Time: $40/hour



	Potential Uses of the System: •Food Science Industry •Botany and Agricultural Sciences •Ex-vivo and In-vivo Imaging •Molecular imaging •Track stem cells in vivo •Macrophage infiltration •Pin-point brain ischemia •Tracking neural pathways •Image Anatomy •Visual airways in the lung •Monitor drug effects •Cardiac & blood vessel MRI •Muscles, tendons & cartilage imaging •Kidney and liver imaging •Transgenic Animals •Oncology •Phenotyping •Atherosclerosis •Neuological disorders	Who could benefit from the Pre-Clinical MRI Center? Our system is very flexible and can be useful for a multitude of disciplines. These include the pharmaceutical and food industry, veterinary, psychology, biomedical sciences, immunology, materials development, and more. Usefulness is only limited by the size of the magnet’s bore. Contact us for a free consultation at brauch@wisc.edu or 608-263-1109.