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Title: NMR flow imaging using a composite excitation field and magnetic field gradient sequence
Patent Number: 04697149 (U.S. patents which cite this patent)
Issue Date: 09-29-1987
Application Date: 11-04-1985
Application Number: 794652
Inventor(s): Name Location
Moran; Paul R. Winston-Salem NC
Assignee(s): Name Location
Wisconsin Alumni Research Foundation Madison WI
Abstract
An NMR zeugmatographic scanner is modified to provide motion images, During each measurement cycle the paramagnetic nuclei are subjected to a pair of transverse excitation field pulses which are separated by the application of a bi-polar magnetic field gradient which sensitizes the resulting FID signal to motion. The resulting FID signal is processed using an inverse Fourier transformation to produce images of flowing paramagnetic nuclei.
Exemplary Claims

Claim 1:

In a gyromagnetic resonance instrument which performs a measurement cycle in which a FID signal produced by gyromagnetic material which is subjected to a polarizing magnetic field and has a magnetic moment is detected and processed to produce an indication of the amount of magnetization, the improvement comprising:

    • excitation means for applying an excitation field to the gyromagnetic material at the Larmor frequency of the gyromagnetic material and at a controllable strength and phase;
    • magnetic field gradient means for applying a magnetic field to the gyromagnetic material which has a gradient in a controlled direction; and
    • control means coupled to the excitation means and the magnetic field gradient means and being operable to perform a measurement cycle that produces a FID signal indicative of the motion of gyromagnetic material, the measurement cycle including:
    • (a) applying a first excitation field pulse which tips the net magnetic moment of the gyromagnetic material away from the direction of the polarizing magnetic field;
    • (b) applying a motion sensitizing magnetic field gradient to the gyromagnetic material which has alternating polarity with respect to the net magnetic moment of the gyromagnetic material and in which the gradient is oriented to the direction in which motion is to be measured;
    • (c) applying a second excitation field pulse having a strength and phase which substantially restores the magnetic moment of stationary gyromagnetic material to the direction of the polarizing magnetic field.
References to US Patents
NumberDateInventor
04516075 1985-05Moran
04516582 1985-05Redington
04528985 1985-07Macovski
04532473 1985-07Wehrli
04536712 1985-08Iwaoka et al.
04549140 1985-10MacFall
04567893 1986-02Charles et al.
04587488 1986-05Young
04595879 1986-06Lent et al.
04602641 1986-07Feinberg
04609872 1986-09O`Donnell
04614195 1986-09Bottomlay et al.
04616180 1986-10Compton
Other References
K. J. Packer, "The Study of Slow Coherent Molecular Motion by Pulsed Nuclear Magnetic Resonance" , Molecular Physics, 1969, vol. 17, No. 4, 355-368.
Sadek K. Hilal, Andrew Maudsley, and Frederick Kelcz, Special Project II- Studies of Two-Dimensional Blood Flow Using Nuclear Magnetic Resonance, pp. 208-229, privileged communication.
Primary Examiner: Noland; Tom
Agents: 5 Quarles & Brady
International Classification: 4G01R 3320
US Classification: 324-309-000 324-306-000
Field of Search: 324-309-000 324-306-000 324-300-000 324-307-000 324-312-000
128-653-000
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