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Title: NMR scanner with motion zeugmatography
Patent Number: RE032701 (U.S. patents which cite this patent)
Issue Date: 06-21-1988
Application Date: 04-08-1987
Application Number: 036103
Inventor(s): Name Location
Moran; Paul R. Winston-Salem NC
Assignee(s): Name Location
Wisconsin Alumni Research Foundation Madison WI
Abstract
An NMR zeugmatographic scanner is modified to produce flow images. A motion sensitizing gradient field is applied to the gyromagnetic nuclei after transverse excitation and prior to emission measurement. The motion sensitized free induction signal which results is processed using an inverse Fourier transformation to produce a number of useful images.
Exemplary Claims

Claim 1:

In a gyromagnetic resonance instrument for producing an image of an extended subject which contains both stationary gyromagnetic material and moving gyromagnetic material, in +L which the instrument +L performs a measurement cycle by applying a transverse excitation signal to a gyromagnetic material and to thereby impart a transverse magnetic moment thereto, and which produces a FID signal responsive to emissions by the transversely magnetized gyromagnetic material, the improvement comprising:

    • means for locating the position of the gyromagnetic material within the extended subject which is producing a FID signal;
    • means for motion sensitizing a FID signal in which a motion sensitizing magnetic field gradient F is applied to the gyromagnetic material for a period of time 2 T after its transverse excitation and prior to the production of the FID signal, and wherein the motion sensitizing magnetic field gradient F has alternating polarity with respect to the gyromagnetic material such that its integral over the time period 2 T is substantially zero; and
    • detector means for receiving the FID signal and producing therefrom a signal S1 (t) which is phase-referenced to the cosine phase of the transverse excitation signal and a signal S2 (t) which is phase-referenced to the sine phase of the transverse excitation signal.
References to US Patents
NumberDateInventor
04015196 1977-03Moore et al.
04021726 1977-05Garroway et al.
04070611 1978-01Ernst
04115730 1978-09Mansfield
04254778 1981-03Clow et al.
04284950 1981-08Burl et al.
04297637 1981-10Crooks
04318043 1982-03Crooks et al.
04319190 1982-03Brown
04339716 1982-07Young
04339718 1982-07Bull et al.
04345207 1982-08Bertrand et al.
04354157 1982-10Feiner
04355282 1982-10Young et al.
04431968 1984-02Edelstein et al.
04443760 1984-04Edelstein et al.
04451788 1984-05Edelstein et al.
04471305 1984-09Crooks et al.
04471306 1984-09Edelstein et al.
04509015 1985-04Ordidge et al.
04516075 1985-05Moran
04528985 1985-07Macovski
Other References
"The NMR Blood Flowmeter-Theory and History" , Battocletti et al., Med Phys. 8(4), Jul./Aug. 1981, pp. 435-443.
"Applications de la Resonance Magnetique Nucleaire en Hemodynamique(*)" , A. Constantiensco et J. Chambron, (Jan. 23, 1981), pp. 127-134.
"NMR Rheotomography: Feasibility and Clinical Potential" -Grant et al., Med Phys. 9(2), Mar./Apr. 1982, pp.188-193.
Packer, K. J.; Rees, C. and Tomlinson, D. J., "A Modification of the Pulsed Magnetic Field Gradient Spin Echo Method of Studying Diffusion," Molecular Physics, 1970, vol. 18(3):421-423.
Kaufman, L. et al., "The Potential Impact of Nuclear Magnetic Resonance Imaging on Cardiovascular Diagnosis," Circulation, An Official Journal of the American Heart Association, Inc., Feb., 1983, 67(2):251-257.
Kaufman, Leon et al., "Evaluation of NMR Imaging for Detection and Quantification of Obstructions in Vessels," Investigative Radiology, Nov.-Dec., 1982, 17(6):554-560.
Hilal et al., "Special Project II-Studies of Two-Dimensional Blood Flow Using Nuclear Magnetic Resonance" , a 377 page proposal submitted to the Dept. of Health, Education and Welfare, pp. 208-229.
J. R. Singer, "NMR Diffusion and Flow Measurements and An Introduction to Spin Phase Graphing" , The Institute of Physics, pp. 281-291.
"Basic Concepts for Nuclear Magnetic Resonance Imaging" -Fullerton Magnetic Resonance Imaging, vol. 1, pp. 39-53, 1982.
Torrey, H. C., "Bloch Equations with Diffusion Terms" , Phys. Rev., 1956, 104:563.
Singer, J. R., "Blood Flow Rates by NMR Measurements," Science, 1959, 130:1652.
Abragam, A., "The Principles of Nuclear Magnetism," London, Oxford University Press, 1961, pp. 58-63.
Stejskal and Tanner, "Spin Diffusion Measurements-," Jour. Chem. Phys., 1965, 42(1):288-292.
Stejskal, E. O., "Use of Spin Echoes in a Pulsed Magnetic Field Gradient to Study Anisotropic, Restricted Diffusion and Flow," Jour. Chem. Phys., 1965, 43(10):3597-3603.
Hahn, Erwin, "Detection of Sea-Water Motion by Nuclear Precession," Jour. Geophys. Res., Feb., 1960, 65(2):776-777.
Packer, K. J., "The Study of Slow Coherent Molecular Motion by Pulsed Nuclear Magnetic Resonance," Molecular Physics, 1969, 17(4):355-368.
Grover, Thomas Peaks; Ph.D. Dissertation, Dept. EE, U.C. Berkeley (examiners Singer, Woodyard and Hahn), Jun. 15, 1971.
Hayward, R. J.; Packer, K. J.; Tomlinson, D. J., "Pulsed Field-Gradient Spin-Echo NMR Studies of Flow in Fluids," Molecular Physics, 1972, 23(6):1083-1102.
Garroway, G. N. "Velocity Measurements in Flowing Fluids by NMR," Jour. Phys. D: Appl. Phys., 1974, vol. 7, pp. L159-L163.
Libove, Joel, "Instrumentation for Imaging of Fluid Flow Using Nuclear Magnetic Resonance With an Example of One-Dimensional Flow Imaging," Doctoral Dissertation.
Fukuda and Hirai, "A Pulsed NMR Study of the Flow in Fluid," Journal of the Physical Society of Japan, Dec., 1979, 47(6):1999-2006.
Singer, J. R. and Crooks, L. E., "NMR Flow Imaging," Proc. Int. Symp. on NMR Imaging, Bowman Gray School of Medicine, Oct., 1981, pp. 185-190.
Mansfield, P. and Morris, P. G., "NMR Imaging in Biomedicine," pp. 235-238.
Van As, H, and Schaafsma, T. J., "Non-Invasive Blood Flow Measurements By the 1 H NMR +90 -Pulse Method," Society of Magnetic Resonance in Medicine, First Annual Meeting, Aug. 16-18, 1982, Boston, Massachusetts, pp. 147-148.
Crooks, L. et al., "Physical Basis of Nuclear Magnetic Resonance Imaging," IEEE Transactions of Nuclear Science, vol. NS-29, Nos. 3, Jun., 1982, pp. 1252-1257.
Deville, G. and Landesman, A., "Experiences D`Echoes de Spins Dans Un Liquide En Ecoulement," Le Journal De Physique, Jan., 1971, pp. 67-72.
Grover, Thomas and Singer, J. R., "NMR Spin-Echo Flow Measurements," Journal of Applied Physics, Mar. 1, 1971, 43(3):938-939.
Grover, Thomas and Singer, J. R., "Recent Measurements of Flow Using Nuclear Magnetic Resonance Techniques," Modern Developments in Flow Measurements, Sep., 1971, pp. 38-46, Proc. the Harwell (Berks, England) Conference, Ed. CG Clayton (The Harwell Atomic Energy Establishment. Peter Perigrinin, Ltd., pub).
Pykett, I. L. and Mansfield, P., "A Line Scan Image Study of a Tumorous Rat Leg by NMR," Phys. Med. Biol., 1978, vol. 23, No. 5, pp. 961-967.
Hahn, E. L., "Spin Echoes," Physical Review, Nov. 15, 1950, vol. 80(4):580-594.
Carr, H. Y. and Purcell, E. M., "Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments," May 1, 1954, vol. 94(3):630-639.
Related Patents Data: 50 455596 19830104 04516075 19850507
Primary Examiner: Tokar; Michael J.
Agents: 5 Quarles & Brady
International Classification: 4G01R 3320
US Classification: 324-309-000 324-306-000
Field of Search: 324-300-000 324-307-000 324-309-000 324-312-000 324-306-000
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