DEPARTMENT OF MEDICAL PHYSICS

UNIVERSITY OF WISCONSIN -School of Medicine & Public Health

 

QUICK LINKS: [Medical Physics Home Page]  [Medical Physics Faculty Profile]

DEPARTMENT OF MEDICAL PHYSICS 

 

Research Areas

Weibo Cai, Ph.D.

Assistant Professor of Radiology & Medical Physics

 

K4/628 Clinical Science Center

600 Highland Avenue

Madison, WI 53792-3252

 

Telephone: 608/262-1749 (office)

Fax: 608/263-4014

E-mail:  wcai@uwhealth.org

 

 

 

  

PROFILE LINKS

  
 

OTHER DEPARTMENT AFFILIATIONS [back to top of page]
  • Radiology

  • Medical Physics

 

EDUCATION [back to top of page]

  
 

  • B.S., 1995, Chemistry, Nanjing University, Najing, China

  • M.S., 2000, Chemistry, University of California, San Diego 

  • Ph.D., 2004, Chemistry, University of California, San Diego

    Advisor:  Professor Murray Goodman

  
  RESEARCH INTEREST [back to top of page]  
 

  • Multimodality Molecular Imaging (PET, optical, MRI)

  • Nanomedicine

  • Molecular Therapy

  

POSITIONS [back to top of page]

  • 2005, Post-Doctoral Training, Molecular Imaging Program at Stanford (MIPS), Sanford University

    Advisor:  Professor Xiaoyuan (Shawn) Chen

 

AWARDS AND HONORS [back to top of page]

  
 

  • 2005-2006, Stanford University School of Medicine and Dean's Fellowship

  • 2005, Travel Award, Society for Molecular Imaging 4th Annual Meeting

  • 2006, Travel Award, Gordon Conference, Chemistry & Biology of Peptides

  • 2006, Travel Award, Academy of Molecular Imaging Annual Conference

  • 2006, Society of Nuclear Medicine Benedict Cassen Post-Doctoral Fellowship

  • 2006, Travel Award, Society for Molecular Imaging 5th Annual Meeting

  • 2007, Society of Nuclear Medicine Young Professional Committee, Best Basic Science Award (1st Place)

  • 2007, Travel Award, Joint Molecular Imaging Conference (SMI & AMI)

 

MEMBERSHIPS [back to top of page]

  
 

  • 2005-Present, Society of Nuclear Medicine (SNM)

  • 2006-Present, Society for Molecular Imaging (SMI)

  

 

PATENTS [back to top of page]

  

  1. Chen X, Cai W, Gambhir SS, Wang H, Chen K, Rodriguez-Porcel M, Willmann JK

    PET imaging of vascular endothelial growth factor receptor (VEGFR), composition for VEGFR imaging, and methods of VEGFR imaging.     US Utility Patent Pending (11/881,384).

 

PUBLICATIONS [back to top of page]

 
 

PEER-REVIEWED ARTICLES (TOTAL OF 46)                   *: Equal Contribution.

  1. Kinberger GA, Cai W, Goodman M. Collagen mimetic dendrimers. Journal of the American Chemical Society, 2002, 124, 15162-15163.

  2. Goodman M, Cai W, Smith ND. The bold legacy of Emil Fisher. Journal of Peptide Science, 2003, 9, 594-603.

  3. Goodman M, Cai W, Kinberger GA. The new science of protein mimetics. Macromolecular Symposia, 2003, 201, 223-236.

  4. Cai W, Kwok SW, Taulane JP, Goodman M. Metal-assisted assembly and stabilization of collagen-like triple helices. Journal of the American Chemical Society, 2004, 126, 15030-15031.

  5. Cai W, Gambhir SS, Chen X. Multimodality tumor imaging targeting integrin αvβ3. BioTechniques, 2005, 39, S6-S17.

  6. Zhang X, Xiong Z, Wu Y, Cai W, Tseng JR, Gambhir SS, Chen X. Quantitative PET imaging of tumor integrin αvβ3 expression with 18F-FRGD2. Journal of Nuclear Medicine, 2006, 47, 113-121.

  7. Zhang X, Cai W, Cao F, Schreibmann E, Wu Y, Wu JC, Xing L, Chen X. 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. Journal of Nuclear Medicine, 2006, 47, 492-501.

  8. Cai W, Chen X. Anti-angiogenic cancer therapy based on integrin αvβ3 antagonism. Anti-cancer Agents in Medicinal Chemistry, 2006, 6, 407-428.

  9. Cai W,* Zhang X,* Wu Y, Chen X. A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide (18F-FBEM),     and the synthesis of RGD peptide-based tracer for PET imaging of αvβ3 integrin expression. Journal of Nuclear Medicine, 2006, 47, 1172-1180.

  10. Cai W,  Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X. Peptide-labeled near-  infrared quantum dots for imaging tumor vasculature in living subjects. Nano Letters, 2006, 6, 669-676.

  11. Wu Y, Cai W, Chen X. Near-infrared fluorescence imaging of tumor integrin αvβ3 expression with Cy7-labeled RGD     multimers. Molecular Imaging and Biology, 2006, 8, 226-236.

  12. Cai W, Wu Y, Chen K, Cao Q, Tice DA, Chen X. In vitro and in vivo characterization of 64Cu-labeled AbegrinTM, a humanized monoclonal antibody against integrin αvβ3. Cancer Research, 2006, 66, 9673-9681.

  13. Cai W, Rao J, Gambhir SS, Chen X. How molecular imaging is speeding up anti-angiogenic drug development. Molecular Cancer Therapeutics, 2006, 5, 2624-2633.

  14. Cai W,* Chen K,* Mohamedali KA, Cao Q, Gambhir SS, Rosenblum MG, Chen X. PET of vascular endothelial growth factor receptor expression. Journal of Nuclear Medicine, 2006, 47, 2048-2056.

  15. Cao Q, Cai W, Li T, Yang Y, Chen K, Xing L, Chen X. Combination of integrin siRNA and irradiation for breast cancer therapy. Biochemical and Biophysical Research Communications, 2006, 351, 726-732.

  16. Li ZB, Cai W, Chen X. Semiconductor quantum dots for in vivo imaging. Journal of Nanoscience and Nanotechnology, 2007, 7, 2567-2581.

  17. Veeravagu A, Hsu AR, Cai W, Hou LC, Tse VCK, Chen X. Vascular endothelial growth factor   and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy. Recent Patents on Anti-Cancer Drug Discovery, 2007, 2, 59-71.

  18. Hsu AR, Veeravagu A, Cai W, Hou LC, Tse V, Chen X. Integrin αvβ3 antagonists for anti-angiogenic cancer treatment. Recent Patents on Anti-Cancer Drug Discovery, 2007, 2, 143-158.

  19. Liu Z,* Cai W,* He L, Nakayama N, Chen K, Sun X, Chen X, Dai H. In-vivo biodistribution and highly efficient tumor targeting of carbon nanotubes in mice. Nature Nanotechnology, 2007, 2,   47-52 (News & Views, Nature Nanotechnology, 2007, 2, 20-21).   

  20. Hsu AR,* Cai W,* Veeravagu A, Mohamedali KA, Chen K, Vogel H, Hou LC, Tse VCK, Rosenblum MG, Chen X. Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel. Journal of Nuclear Medicine, 2007, 48, 445-454.

  21. Cai W,* Chen K,* He L, Cao Q, Koong A, Chen X. Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34, 850_858.

  22. Niu G, Xiong Z, Cheng Z, Cai W, Gambhir SS, Xing L, Chen X. In vivo bioluminescence tumor    imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene. Molecular Imaging and Biology, 2007, 9, 126-134.

  23. Cai W, Wong D, Kinberger GA, Kwok SW, Taulane JP, Goodman M. Facile and efficient assembly of collagen-like triple helices on a TRIS scaffold. Bioorganic Chemistry, 2007, 35, 327-337.

  24. Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X. 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of αvβ3 integrin expression. European Journal of  Nuclear Medicine and Molecular Imaging, 2007, 34, 1823-1831.

  25. Cai W, Taulane JP, Sorto NA, Oganesyan A,Gutierrez CG, Goodman M. Scaffold assembly of     collagen-like triple helices at the C-terminus. Letters in Organic Chemistry, 2007, 4, 96-101.

  26. Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, Chen X. 64Cu-labeled tetrameric and octameric  RGD peptides for small-animal PET of tumor αvβ3 integrin expression. Journal of Nuclear Medicine, 2007, 48, 11621-1171.

  27. Cao Q,* Cai W,* Li ZB, Chen K, He L, Li HC, Hui M, Chen X. PET imaging of acute and chronic inflammation in living mice. European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34, 1832-1842.

  28. Cai W, Chen X. Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression. Frontiers in Bioscience, 2007, 12, 4267-4279.

  29. Cai W, Hsu AR, Li ZB, Chen X. Are quantum dots ready for in vivo imaging in human subjects? Nanoscale Research Letters, 2007, 2, 265-281.

  30. Cai W,* Ebrahimnejad A,* Chen K, Cao Q, Li ZB, Tice DA, Chen X. Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice. European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34, 2024-2036.

  31. Wang H,* Cai W,* Chen K, Li ZB, Kashefi A, He L, Chen X. A new PET tracer specific for vascular endothelial growth factor receptor 2. European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34, 2001-2010.

  32. Cai W, Chen K, Li ZB, Gambhir SS, Chen X. Dual-function probe for PET and near-infrared       fluorescence imaging of tumor vasculature. Journal of Nuclear Medicine, 2007, 48, 1862-1870.

  33. Wu Z, Li ZB, Chen K, Cai W, He L, Chin FT, Li F, Chen X. MicroPET of tumor integrin αvβ3 expression using 18F-labeled PEGylated tetrameric RGD peptide  (18F-FPRGD4). Journal of Nuclear Medicine, 2007, 48, 1536-1544.

  34. Cai W, Chen X. Nanoplatforms for targeted molecular imaging in living subjects. Small, 2007, 3, 1840-1854.

  35. Cai W, Olafsen T, Zhang X, Cao Q, Gambhir SS, Williams LE, Wu AM, Chen X. PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody. Journal of Nuclear Medicine, 2007, 48, 304-310 (Invited    Perspective, Journal of Nuclear Medicine, 2007, 48, 170-172).

  36. Rodriguez-Porcel M, Cai W, Gheysens O, Chen IY, Chen K, He L, Willman JK, Wu JC, Li ZB, Mohamedali KA, Kim S, Rosenblum MG, Chen X, Gambhir SS. Imaging of VEGF receptor in a rat myocardial infarction model using positron emission tomography. Journal of Nuclear Medicine, in press.

  37. Niu G, Cai W, Chen X. Molecular imaging of human epidermal growth factor receptor 2 (HER- 2) expression. Frontiers in Bioscience, 2008, 13, 790-805.

  38. Niu G, Cai W, Chen K, Chen X. Non-invasive PET imaging of EGFR degradation induced by heat shock protein 90 inhibitor. Molecular Imaging and Biology, 2008, Epub.

  39. Cai W, Chen X. Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted   imaging. Nature Protocols, 2008, 3, 89-96.

  40. Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. Journal of Nuclear  Medicine, 2008, in press.

  41. Willmann JK, Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, Wang DS, Chen IY, Gheysens O, Rodriguez-Porcel M, Chen X, Gambhir SS. Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography. Circulation, 2008, 117, 915-922.

  42. Veeravagu A, Hou LC, Hsu AR, Cai W, Greve JM, Chen X, Tse V. The temporal correlation of dynamic contrast enhanced magnetic resonance imaging with tumor angiogenesis in a murine glioblastoma model. Neurological Research, in press.

  43. Wang H, Chen K, Cai W, Li ZB, He L, Kashefi A, Chen X. Integrin targeted imaging and therapy with RGD4C-TNF fusion protein. Molecular Cancer Therapeutics, accepted.

  44. Liu Z, Davis C, Cai W, He L, Chen X, Dai H. Circulation and long-term fate of functionalized,  biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy.    Proceedings of the National Academy of Sciences of the United States of America, 2008, 105,1410-1415.

  45. Cao Q, Cai W, Niu G, He L, Chen X. Multimodality imaging of IL-18bp-Fc therapy of experimental lung metastasis. Clinical Cancer Research, revision.

  46. Cai W, Niu G, Chen X. Multimodality imaging of the HER-kinase axis in cancer. European  Journal of Nuclear Medicine and Molecular Imaging, 2008, 35, 186-208.

BOOK CHAPTERS (TOTAL OF 2)  [back to top of page]

  1. Cai W, Chen X "Multimodality agents Molecular Imaging: Principles and Practice" (Editors, Ralph Weissleder, Sanjiv S Gambhir, Brian D Ross, Alnawaz Rehemtulla) [Chapter 32]    Publisher: BC Dekker

  2. Cai W, Gambhir SS, Chen X "Molecular imaging of tumor vasculature Methods in Enzymology: Angiogenesis" (Editor, David Cheresh) [Chapter 12] Publisher:  Elsevier

PROFESSIONAL SERVICE  [back to top of page]

Journal Reviews:

  • Clinical & Experimental Metastasis

  • Journal of Nuclear Medicine

  • Molecular Imaging & Biology

Last Modified: 04/01/2008

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