DEPARTMENT OF MEDICAL PHYSICS

UNIVERSITY OF WISCONSIN MEDICAL SCHOOL

QUICK LINKS: [Medical Physics Home Page]  [Medical Physics Faculty Profile]

Research Areas

• Radiation Dosimetry,  Radiation Protection

• Biomagnestism

• Bone Densitometry

• Diagnostic X-ray Imaging

• Magnetic Resonance    Imaging (MRI)

• Nuclear Medicine, PET, Molecular Imaging

• Optical Spectroscopy

• Radiation Therapy Physics

• Ultrasound Imaging

Photo Not Available

James E. Holden Ph.D.

Professor

B1137 Wisconsin Institutes for Medical Research

UW-Medical Physics

Madison, WI 53706

Telephone: 608/262-5998

Fax: 608/262-2413

E-mail:  jeholden@wisc.edu

PROFILE LINKS

• Other Department Affiliations

• Education

• Research Interests

• Awards and Honors

• Memberships

• Publications (recent)

OTHER DEPARTMENT AFFILIATIONS

• Medical Physics
• Radiology

EDUCATION

• B.S., , Physics, Providence College (RI)

• Ph.D.,  Nuclear Physics, University of Pennsylvania

RESEARCH INTERESTS

AWARDS AND HONORS (most recent first)

• Picker Scholar, James A Picker Foundation

MEMBERSHIPS

• Society of Cerebral Blood Flow and Metabolism

• Society of Nuclear Medicine

• Society of Neuroscience

• Fellow, American Heart Association

PUBLICATIONS (most recent first)

• Endres CJ. DeJesus OT. Uno H. Doudet DJ. Nickles JR. Holden JE. Time profile of cerebral [18F]6-fluoro-L-DOPA metabolites in nonhuman primate: implications for the kinetics of therapeutic L-DOPA. Frontiers in Bioscience. 9:505-12, 2004 Jan 1.

• Sossi V. de la Fuente-Fernandez R. Holden JE. Schulzer M. Ruth TJ. Stoessl J. Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms.  Journal of Cerebral Blood Flow & Metabolism. 24(8):869-76, 2004 Aug.

• Doudet DJ. Holden JE. Raclopride studies of dopamine release: dependence on presynaptic integrity. Biological Psychiatry. 54(11):1193-9, 2003 Dec 1.

• Doudet DJ. Holden JE. Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: effect of methamphetamine. Journal of Cerebral Blood Flow & Metabolism. 23(12):1489-94, 2003 Dec.

• DeJesus OT. Shelton SE. Roberts AD. Nickles RJ. Holden JE. Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys. Synapse. 44(4):246-51, 2002 Jun 15.

• Lee CS. Samii A. Sossi V. Ruth TJ. Schulzer M. Holden JE. Wudel J. Pal PK. de la Fuente-Fernandez R. Calne DB. Stoessl AJ. In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease.  Annals of Neurology. 47(4):493-503, 2000 Apr.

• Sossi V. Holden JE. Chan G. Krzywinski M. Stoessl AJ. Ruth TJ. Analysis of four dopaminergic tracers kinetics using two different tissue input function methods.  Journal of Cerebral Blood Flow & Metabolism. 20(4):653-60, 2000 Apr.

• Chan GL. Holden JE. Stoessl AJ. Samii A. Doudet DJ. Dobko T. Morrison KS. Adam M. Schulzer M. Calne DB. Ruth TJ. Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects. [Journal Article] Journal of Nuclear Medicine. 40(2):283-9, 1999 Feb.

  ---

QUICK LINKS: [Medical Physics Home Page]  [Medical Physics Faculty Profile] [back to top of page]