Metastatic disease that has spread to the brain affects approximately up to 40% of cancer patients.  In order to treat brain lesions and systematic disease, a combination of whole brain radiation therapy and chemotherapy is generally used.  Recent studies have indicated that effective therapy improves cognitive function though radiation is known to damage brain structures.  Four patients were examined in the pilot phase of this study and each of them exhibited an extended network of attentional control 6 weeks post-therapy compared to the pre-therapy baseline measures.   The findings obtained using the Simon task were replicated in patients who completed a self-paced version of the n-back working memory paradigm.  While increased fMRI activations post-therapy  are in line with other studies, we attempted a more complete explanation through several advanced imaging methods.  Seed connectivity, deformation based morphometry, multi-spectral segmentation and histogram analyses were applied to anatomical and physiologic scans, including T1, T2 FLAIR, structural scans, apparent diffusion coefficient and fractional anisotropy maps from diffusion tensor imaging and magnetization transfer ratio maps.  As complicated as that all sounds, some initial results obtained in a pediatric medulloblastoma patient will complete the talk in order to summarize conclusions and future directions more simply.