
Publications
2013
- Christian, B. T., Wooten, D. W, Hillmer, A. T., Tudorascu, D. L., Converse, A. K., Moore, C. F., Ahlers, E. O., Barnhart, T. E., Kalin, N. H., Barr, C. S., Schneider, M. L. Serotonin Transporter Genotype Affects Serotonin 5-HT1A Binding in Primates. J Neurosci. 2013; 33(6):2512-6
- Shi, S., Yang, K., Hong, H., Valdovinos, H. F., Nayak, T.R., Zhang, Y., Theuer, C. P., Barnhart, T. E., Liu, Z., Cai, W. Tumor vasculature targeting and imaging in living mice with reduced graphene oxide. Biomaterials. 2013; 34(12):3002-9
- Hillmer, A. T., Wooten, D. W., Farhoud, M., Barnhart, T. E., Mukherjee, J., Christian, B. T. The effects of lobeline on α4β2* nicotinic acetylcholine receptor binding and uptake of [18F]nifene in rats. J Neurosci Methods. 2013
- Zhang, Y., Hong, H., Orbay, H., Valdovinos, H. F., Nayak, T. R., Theuer, C. P., Barnhart, T. E., Cai, W. PET imaging of CD105/endoglin expression with a 61/64Cu-labeled Fab antibody fragment. Eur J Nucl Med Mol Imaging. 2013
- Hong, H., Zhang, Y., Orbay, H., Valdovinos, H. F., Nayak, T. R., Bean J., Theuer, C. P., Barnhart, T. E., Cai, W. Positron Emission Tomography Imaging of Tumor Angiogenesis with a (61/64)Cu-Labeled F(ab')(2) Antibody Fragment. Mol Pharm. 2013; 10(2):709-16.
- Murali, D., Barnhart, T. E., Vandehey, N. T., Christian, B. T., Nickles, R. J., Converse, A. K., Larson, J. A., Holden, J. E., Schneider, M. L., Dejesus, O. T. An efficient synthesis of dopamine transporter tracer [18F]FECNT. Appl Radiat Isot 2013; 72:128-132
2012
- Joers, V; Seneczko, K; Goecks, NC; Kamp, TJ; Hacker, TA; Brunner, KG; Engle, JW; Barnhart, TE; Nickles, RJ; Holden, JE; Emborg, ME. Nonuniform cardiac denervation observed by 11C-meta-hydroxyephedrine PET in 6-OHDA-treated monkeys. PLoS One. 2012; 7(4):e35371. Epub 2012 Apr 23. PMC 3335153
- Engle, JW; Hong, H; Zhang, Y; Valdovinos, HF; Myklejord, DV; Barnhart, TE; Theuer, CP; Nickles, RJ; Cai, W. Positron emission tomography imaging of tumor angiogenesis with a 66Ga-labeled monoclonal antibody. Mol Pharm. 2012 May 7; 9(5):1441-8. Epub 2012 Apr 21 PMC 3375902
- Hong, H; Severin GW; Yang; YA, Engle, JW; Zhang, Y; Barnhart, TE; Liu G; Leigh, BR; Nickles, RJ; Cai, WB. Positron emission tomography imaging of CD105 expression with Zr-89-Df-TRC105. Eur J Nucl Med and Molecular Imaging 39:138-48, 2012. PMC 3228902
- Hong, H; Zhang, Y; Engle, JW, Nayak, TR; Theurer, CP; Nickles, RJ; Barnhart, TE; Cai, WB. In vivo targeting and positron emission tomography imaging of tumor vasculature with Ga-66 labeled nano-graphene. Biomaterials 33: 4147-56, 2012. PMC 3313015.
- ImmunoPET and near-infrared fluorescence imaging of CD105 expression using a monoclonal antibody dual-labeled with (89)Zr and IRDye 800CW. Yin Zhang, Hao Hong, Gregory W Severin, Jonathan W Engle, Yunan Yang, Shreya Goel, Alex J Nathanson, Glenn Liu, Robert J Nickles, Bryan R Leigh, Todd E Barnhart, Weibo Cai American Journal of Translational Research 01/2012; 4(3):333-46.
- Joers, Valerie; Seneczko, Kailie; Goecks, Nichole C., Kamp TJ, Hacker TA, Brunner KJ, Engle JW, Barnhart TE, Nickles RJ, Holden JE, Emborg ME. Nonuniform Cardiac Denervation Observed by C-11-meta-Hydroxyephedrine PET in 6-OHDA-Treated Monkeys. PLOS ONE Volume: 7 Issue: 4 Article Number: e35371 DOI:10.1371/journal.pone.0035371 Published: APR 23 2012
- Engle, J W; Lopez-Rodriguez, V; Gaspar-Carcamo, R E; Valdovinos, H F; Valle-Gonzalez, M; Trejo-Ballado, F; Severin, G W; Barnhart, T E; Nickles, R J; Avila-Rodriguez, M A. Very high specific activity (66/68)Ga from zinc targets for PET. Applied radiation and isotopes, Volume: 70 Issue: 8 Pages: 1792-6 Published: 2012-Aug (Epub 2012 Mar 2)
- Hong, Hao; Zhang, Yin; Engle, Jonathan W, Nayak TR, Theuer CP, Nickles RJ, Barnhart TE, Cai W. In vivo targeting and positron emission tomography imaging of tumor vasculature with Ga-66-labeled nano-graphene. BIOMATERIALS Volume: 33 Issue: 16 Pages: 4147-4156 DOI:10.1016/j.biomaterials.2012.02.031 Pub: JUN 2012
- Severin, G W; Engle, J W; Valdovinos, H F, Barnhart TE, Nickles RJ. Cyclotron produced (44g)Sc from natural calcium. Applied radiation and isotopes Volume: 70 Issue: 8 Pages: 1526-30 Published: 2012-Aug (Epub 2012 May 24).
- Murali D, Barnhart TE, Vandehey NT, Christian BT, Nickles RJ, Converse AK, Larson JA, Holden JE, Schneider ML, DeJesus OT. An efficient synthesis of dopamine transporter tracer [F-18] FECNT. Applied Radiation and Isotopes 70, 128-132, 2012.
- Xiao YL, Hong H, Matson VZ, Javidi A, Xu W, Yang YA, Zhang Y, Engle JW, Nickles RJ, Cai WB, Steeber DA, Gong SQ. Gold nanorods conjugated with Doxorubicin and cRGD for combined anticancer drug delivery and PET imaging. Theranostics 2, 757-768, 2012.
- Zhang, Y., Hong, H., Niu, G., Valdovinos, H. F., Orbay, H. K., Nayak, T. R., Chen, X. Y., Barnhart, T. E., Cai, W. Positron Emission Tomography Imaging of Vascular Endothelial Growth Factor Receptor Expression with 61Cu-Labeled Lysine-Tagged VEGF(121). Mol Pharm 2012; 9(12):3586-3594
- Hong, H., Zhang, Y., Nayak, T. R., Engle, J. W., Wong, H. C., Liu, B., Barnhart, T. E., Cai, W. Immuno-PET of Tissue Factor in Pancreatic Cancer. J Nucl Med 2012; 53:1748-1754
- Hillmer, A. T., Wooten, D. W., Slesarev, M. S., Ahlers, E. O., Barnhart, T. E., Murali, D., Schneider, M. L., Mukherjee, J., Christian, B. T. PET Imaging of α4β2* Nicotinic Acetylcholine Receptors: Quantitative Analysis of 18F-Nifene Kinetics in the Nonhuman Primate. J Nucl Med 2012; 53(9):1471-1480
- Yang, Y., Niu, Y., Hong, H., Wu, H., Zhang, Y., Engle, J. W., Barnhart, T. E., Cai, J., Cai, W. Radiolabeled c-AApeptides: a new class of tracers for positron emission tomograph. Chem Comm 2012; 48:7850-7852
- Wooten, D. W., Hillmer A. T., Moirano, J. M., Ahlers, E. O., Slesarev, M., Barnhart, T. E., Mukherjee, J., Schneider, M. L., Christian, B. T. Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [18F]mefway in the nonhuman primate. J Cereb. Blood Flow Metab 2012; 32(8):1546-1558
- Hong, H., Yang, K., Zhang, Y., Engle, J. W., Feng, L., Yang, Y., Nayak, T. R., Goel, S., Bean, J., Theuer, C. P., Barnhart, T. E., Liu, Z., Cai, W. In-Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene. ACS Nano 2012; 6(3):2361-2370
- Zhang, Y., Hong, H., Engle, J. W., Yang, Y., Theuer, C. P., Barnhart, T. E., Cai, W. Positron Emission Tomography and Optical Imaging of Tumor CD105 Expression with a Dual-Labeled Monoclonal Antibody. Mol Pharm 2012; 9(3):645-653
- Xiao, Y., Hong, H., Javadi, A., Engle, J. W., Xu, W., Yang, Y., Zhang, Y., Barnhart, T. E., Cai, W., Gong, S. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials 2012; 33(11):3071-3082
- Zhang, Y., Hong, H., Engle, J.W., Yang, Y, Barnhart, T.E., Cai, W. Positron emission tomography and near-infrared fluorescence imaging of vascular endothelial growth factor with dual-labeled bevacizumab. Am J of Nuc Med and Mol Imag 2012; 1:1-13
2011
- Alexander K. Converse, Eric C. Larsen, Jonathan W. Engle, Todd E. Barnhart, Robert J. Nickles, Ian D. Duncan [C-11](R)-PK11195 PET Imaging of Microglial Activation and Response to Minocycline in Zymosan Treated Rats. J Nucl Med 52; Feb 2011, 257-62.
- Gallagher CL, Oakes TR, Johnson SC, Chung MK, Holden JE, Bendlin BB, McLaren DG, Xu G, Nickles RJ, Pyzalski R, Dejesus O, Brown WD. Rate of 6-[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease. Mov Disord. 2011 Mar; 26(4):614-20. Epub 2011 Mar 29. PMID: 21449008
- Positron emission tomography imaging of CD105 expression during tumor angiogenesis. Hong H, Yang Y, Zhang Y, Engle JW, Barnhart TE, Nickles RJ, Leigh BR, Cai, W. Eur J Nucl Med Mol Imaging. 2011 Mar 4. PMID: 21373764
- Yang X, Hong H, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Xiao Y, Yang Y, Zhang Y, Nickles RJ, Cai W, Steeber DA, Gong S. cRGD-functionalized, DOX-conjugated, and (64)Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials. 2011 Jun; 32(17):4151-60. Epub 2011 Mar 2. PMID: 21367450
- Engle JW, Barnhart TE DeJesus OT, Nickles RJ. Production of Cl-34m and Cl-38 via the (d, alpha) reaction on Ar-36 and natural Ar gas at 8.4 MeV. Appl Rad Isotopes 2011 Jan; 69(1): 75-79. Epub 2010 Sept 21 PMID 208842215.
- Hao, H; Hélène, AB; Zhang, Y; Yang, Y; Uyeda, HT; Engle, JW; Severin, GW; McDougall, MG; Barnhart, TE; Klaubert, DH; Nickles, RJ; Fan, F; Cai W. HaloTag: a novel reporter gene for positron emission tomography. Am J Transl Res. 2011 August 15; 3(4): 392-403. PMCID: PMC 3158741.
- Hong H; Yang Y; Zhang Y; Engle JW; Barnhart TE; Nickles RJ; Leigh BR; Cai W. Positron emission tomography imaging of CD105 expression during tumor angiogenesis. Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1335-43. PMC3105181
- Wooten DW, Moraino JD, Hillmer AT, Engle JW, Dejesus OJ, Murali D, Barnhart TE, Nickles RJ, Davidson RJ, Schneider ML, Mukherjee J, Christian BT. In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate. Synapse. 2011 Jul; 65(7):592-600. PMC 3080024.
- Gallagher, CL; Oakes, TR; Johnson, SC; Chung, MK; Holden, JE; Bendlin, BB; McLaren, DG; Xu, GF; Nickles, RJ; Pyzalski, R; DeJesus, O; Brown;, WD. Rate of 6-[F-18]FluoroDOPA uptake in Striatal Subregions in Parkinson's disease. Movement Disorders 26: 614-620, 2011. PMC 3080432.
- Vanderhoek, M; Juckett, MB; Perlman, SB; Nickles, RJ; Jeraj, R. Early assessment of treatment response in patients with AML using [F-18]FLT PET imaging. Leukemia Research 35: 310-316, 2011. PMC 3319294.
- Hong, H; Shi, J; Yang, YA; Zhang, Y; Engle, JW; Nickles, RJ; Wang, XD; Cai, WB. Cancer-targeted optical imaging with fluorescent zinc oxide nanowires. Nano Letters 11: 3744-50, 2011. PMC 3173586
- Gallagher, CL; Christian, BT; Holden, JE; Dejesus, OT; Nickles, RJ; Buyan-Dent, L; Bendlin, BB; Harding, SJ; Stone, CK; Mueller, B; Johnson, SC. A within-subject comparison of 6-[F-18]Fluoro-L-DOPA in Parkinson's disease. Movement Disorders 26: 2032-38, 2011. PMC 3278160.
- Severin, GW; Engle, JW; Barnhart, TE; Nickles, RJ. Zr-89 radiochemistry for positron emission tomography. Medicinal Chemistry 7: 389-94, 2011. PMCID in process.
- Hillmer, AT; Wooten, DW; Moirano, JM; Slesarev, M; Barnhart, TE; Engle, JW; Nickles, RJ; Murali, D; Schneider, ML; Mukherjee, J; Christian, BT. Specific alpha-4 beta-2 Nicotinic Acetylcholine Receptor Binding of [F-18] Nifene in the Rhesus Monkey. Synapse 65; 1309-18, 2011. PMCID in process, EPub Aug 31, 2011.
- Zhang, Y., Hong, H., Engle, J. W., Bean, J., Yang. Y., Leigh, B. R., Barnhart, T. E., Cai, W. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled antibody: NOTA is superior to DOTA. PLoS ONE, 2011, 6, e28005
- Wooten, D., Hillmer, A., Murali, D., Barnhart, T. E., Schneider, M. L., Mukherjee, J., Christian, B. T. An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate. Nucl Med Biol 2011; 38(7):925-932
2010
- Bartlett RM, Nickles RJ, Barnhart TE, Christian BT, Holden JE, DeJesus OT. Fetal dose estimates for (18)F-fluoro-L-thymidine using a pregnant monkey model. J Nucl Med. 2010 Feb;51(2):288-92. Epub 2010 Jan 15.PMID: 20080884
- Bartlett RM, DeJesus OT, Barnhart TE, Nickles RJ, Christian BT, Graner JL, Holden JE. Petal dopamine receptor characteristics assessed in utero. J Cereb Blood Flow and Metab. 2010 Aug: 30(8) 1437-40. Epub 2010 Jun 9, PMID:20080884.
- Barbee DL, Flynn RT, Holden JE, Nickles RJ, Jeraj R. A method for partial volume correction of PET-imaged tumor heterogeneity using expectation maximization with a spatially varying point spread function. Phys Med Biol. 2010 Kan 7: 55(1): 221-6. PMID: 20009194.
2009
- Vandehey NT, Garell PC, Hampel JA, Murali D, Smith EM, Converse AK, Nickles RJ, Davidson RJ, Christian BT. PET measurement of changes in striatal and extrastriatal D2/D3 dopamine receptor binding during chronic deep brain stimulation in nonhuman primates. Neuroscience Methods 176(2): 129-135, 2009.
- Christian BT, Vandehey NT, Fox AS, Murali D, Oakes TR, Converse AK, Nickles RJ, Shelton SE, Davidson RJ, Kalin NH. The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging. NeuroImage 44(4): 1334-1344, 2009.
- Bartlett RM, Holden JE, Nickles RJ, Murali D, Barbee DL, Barnhart TE, Christian BT, DeJesus OT. Paraquat is excluded by the blood brain barrier in rhesus macaque: an in vivo PET study. Brain Research 1259:74-79, 2009.
- Vandehey VT, Moirano JM, Converse AK, Holden JE, Mukherjee J, Murali D, Nickles RJ, Davidson RJ, Schneider ML, Christian BT. High affinity dopamine D2/D3 PET radioligands 18F-fallypride and 11C-FLB457: A comparison of kinetics in extrastriatal regions using a multiple-injection protocol. J Cereb Blood Flow Metab (Accepted for Publication) 2009.
- Barbee DL, Flynn RT, Holden JE, Nickles RJ, Jeraj R. Partial volume correction of PET-imaged tumor heterogeneity using expectation maximization with a spatially varying point spread function. (submitted to Phys Med Biol)
- Vandehey NT, Garell PC, Hampel JA, Murali D, Smith EM, Davidson R, Converse AK, Nickles RJ and Christian BT (2009) PET measurement of changes in D2/D3 dopamine receptor binding in a nonhuman primate during chronic deep brain stimulation of the bed nucleus of the stria terminalis. J. Neurosci. Methods 176:129-135.
- Vandehey NT, Moirano JM, Converse AK, Holden JE, Mukherjee J, Murali D, Nickles RJ, Davidson RJ, Schneider ML, Christian BT. High-affinity dopamine D(2)/D(3) PET radioligands (18)F-fallypride and (11)C-FLB457: A comparison of kinetics in extrastriatal regions using a multiple-injection protocol. J Cereb Blood Flow Metab. 2009 Dec 30. PMID: 20040928
2008
- Nickles RJ, Avila-Rodriguez MA, Nye JA, Houser EN, Selwyn RG, Schueller MJ, Christian BT, Jensen M. Sustainable production of orphan radionuclides at Wisconsin. Q J Nucl Med Mol Imaging 52(2): 134-139, 2008.
- Selwyn R, Micka J, DeWerd L, Nickles R, Thomadsen B. Technical note: The calibration of [Y-90]-labeled SIR spheres using a nondestructive spectroscopic assay. Med Phys 2008 Apr; 35(4) 1278-9. PMID 18491520.
- Kasyutich, V. L., McMahon, A., Barnhart, T., Martin, P. A. On-line monitoring of cyclotron target-gas output by means of tunable lead salt diode laser absorption spectroscopy. Appl Phy B-Lasers and Optics 2008; 93(2-3):701-711
2007
- Nye JA, Avila-Rodriguez MA, Nickles RJ. A new binary compound for the production of I-124 via the 124Te(p,n)124I reaction. Appl. Radiat. Isot. 65 (4) 407-412 (2007).
- Selwyn RG, Nickles RJ, Thomadsen BR, DeWerd LA, Micka JA. A new internal pair production branching ratio of Y-90: The development of a non-destructive assay for Y-90 and Sr-90. Appl Rad Isotopes 65 (2007), 318-327.
- Avila-Rodriguez MA, Nye JA, Nickles RJ. Simultaneous production of high specific activity Cu-64 and Co-61 with 11.4 MeV protons on enriched Ni-64 nuclei. (accepted ARI, 2007).
- Avila-Rodriguez MA, Nye JA, Nickles RJ. Production and separation of non-carrier-added Y-86 from enriched Sr-86 nuclei. (accepted by Appl Rad Isotopes, 2007).
- Avila-Rodriguez MA, Selwyn RG, Hampel JA, Thomadsen BR, DeJesus OT, Converse AK, Nickles RJ. Positron emitting resin microspheres as surrogates of Y-90 SIR-Spheres: A radiolabeling and stability study. Nucl Med Biol 34:585-590 (2007).
- R G Selwyn, M A Avila-Rodriguez, A K Converse, J A Hampel, C J Jaskowiak, J C McDermott, T F Warner, B R Thomadsen and R J Nickles. 18F-labeled resin microspheres as surrogates for 90Y resinmicrospheres used in the treatment of hepatic tumors: radiolabeling and biodistribution study. Phys Med Biol. 52, 7397-7408, 2007
- Avila-Rodriguez MA, Nye JA, Nickles RJ. Simultaneous production of high specific activity 64Cu and 61Co with 11.4MeV protons on enriched 64Ni nuclei. Int J Appl Rad Isotopes 65, 1115-1120, 2007.
2006
- Nye JA, Avila-Rodrigues MA, Nickles RJ. A Grid-Mounted Niobium Body Target for the Production of Reactive [F-18]-Fluoride. Int J Appl Rad Isotopes 65, 536-539, (2006).
- Nye JA, Avila-Rodriguez MA, Nickles RJ. Production of [I-124]-iodine on an 11 MeV cyclotron. Radiochim Acta 94, 213-216 (2006).
- Nye JA, Dick DW, Avila-Rodriguez MA, Nickles RJ. Radiohalogen targetry at the University of Wisconsin. Nucl Instr Meth B, 241 (2006) 693-696.
- DeJesus OT, Flores LG, Converse AK, Balett RM, Murali D, Jeraj R, Oakes TR, Nickles RJ, Jaskowiak CJ. Assessing environmental chemical uptake in fetal brain in utero: A preliminary PET/CT study. J Radioanalytical Nucl Chem 269:561-564 (2006).
- Ballegeer, EA, Forrest, LJ, Jeraj, R, Mackie, TR, and Nickles, RJ. PET/CT following intensity-modulated radiation therapy for primary lung tumor in a dog. Vet Radiol Ultrasound 47(2), 228-33 (2006).
2005
- Roberts AD, Barnhart TE, Dabbs KA, Converse AK, Schueller MJ, Nickles RJ. Production of the Short-Lived PET Flow Tracer [17F]CH3F using 11 MeV Protons or 6 MeV deuterons. 62, 525-532, 2005.
- Barnhart TE. Production of [F-17] Fluoromethane (t 1/2= 65 sec), an improved PET tracer for rCBF measurement. J Appl Rad Isotopes 62, (2005) 525-32.
- M.L. Schneider, C.F. Moore, T.E. Barnhart, J.A. Larson, O.T. DeJesus, J. Mukherjee, R.J. Nickles, A.K. Converse, A.D. Roberts, G.W. Kraemer. Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys. Alcohol Clin Exp Res. Sep; 29(9):1685-97. 2005
- DeJesus OT, Flores LG, Roberts AD, Dick DW, Bartlett RM, Murali D, Nickles RJ. Aromatic L-amino acid decarboxylase (AAAD) activity in rhesus macaque striatum after MAO-B inhibition by Ro 16-6491. Synapse 56(1):54-6, 2005 Apr.
2004
- Converse AK, Barnhart TE, Dabbs KA, Dejesus OT, Larson JA, Nickles RJ, Schneider ML, Roberts AD. Simultaneous PET Imaging of rCBF and Neurochemical Function. Journal Neuroscience Methods 132, 199-208: (2004).
- Roberts AD, Barnhart TE, DeJesus OT, Larson J, Nickles RJ, Schueller MJ, Shelton SE, Moore C, Schneider ML. Fetal Alcohol Exposure and Pre-Natyal Stress Result in Altered Dopamine Function in Monkeys. Neurotoxicology and Teratology 26, (2004) 169-178.
- Nickles RJ, Barnhart TE, Avila-Rodrigues MA, Converse AK, Sundaresan R, Nye JA, Dick DW, Roberts AD. Production of 16N2 for Instrument Calibration. Radiochimica Acta 92: 1-4 (2004).
- Converse AK, Barnhart TE, Dabbs KA, DeJesus OT, Larson J, Nickles RJ, Schneider ML, Roberts AD. PET Measurement of rCBF in the Presence of a Neurochemical Tracer. J Neurosci Methods 132. (2004), 199-208
- Ferrarelli, F., Haraldsson, H. M., Barnhart, T. E., Roberts, A. D., Oakes, T. R., Massimini, M., Stone, C. K., Kalin, N. H., Tononi, G. A [17F]-fluoromethane PET/TMS study of effective connectivity. Brain Res 2004; 64:103-113
2003
- Murali D, Flores LG, Roberts AD, Nickles RJ, DeJesus OT. Aromatic L-Amino Acid Decarboxyases (AAAD) Inhibitors as Carcinoid Tumor Imaging Agents: Synthesis of [F-18] Labeled A-Fluoro-methyl-6-Fluoro-m-tyrosine (FM6FmT). J Appl Rad Isotopes 59, 237-243 (2003).
- Barnhart TE, Converse AK, Dabbs KA, Nickles RJ, Roberts AD. Water Cooled Grid Support System for High Power Irradiation of Thin Target Windows. Appl Radiation and Isotopes 58, 21-26 (2003).
2002
- Schueller MJ, Mulnix TL, Christian BT, Jensen M, Holm S, Oakes TR, Roberts AD, Dick DW, Martin CC, Nickles RJ. Addressing the Third Gamma Problem in PET. MO5A-26ì. Nucl Sci Symp (2002).
- Roberts AD, DeJesus OT, Larson JA, Nickles RJ, Schueller MJ, Shelton SE, Moore CF, Schneider ML. Moderate Level Fetal Alcohol Exposure, Prenatal Stress and Dopamine System Function in Rhesus Monkeys. Part I. Alcoholism: Clinical and Experimental Research.
- DeJesus OT, Shelton SE, Roberts AD, Nickles RJ, Holden JE. Effect of Tetrabenazine on the Striatal Uptake of Exogenous of L-DOPA in Vivo. Synapse 44: 246-251 (2002).
- Schueller MJ, Nickles RJ, Roberts AD. Production and Extraction of 10CO2 from Proton Bombardment of Molten 10B2O3. Am Inst Physics Press, Oct 2002.
- Barnhart TE, Nickles RJ, Roberts AD. Revisiting Low Energy Deuteron Production of [18F] Fluoride and Fluorine for PET. Am Inst Physics Press, Oct 2002, 1086-1089.
2001
- Nickles RJ. A Positron Floodlight for PET Attenuation Measurements. IEEE Trans Nucl Sci 48 (1), 157-162 (2001).
- Wallhaus TR, Taylor MD, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK. Myocardial Free Fatty Acid and Glucose Use After Carvedilol Treatment in Patients with Congestive Heart Failure. Circ 103, 2442-6 (2001).
- Taylor MD, Wallhaus TR, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK. An Evaluation of Myocardial Fatty Acid and Glucose Uptake using PET and [F-18] Fuoro-6-Thia Heptadecanoic Acid and [F-18]FDG in patients with Congestive Heart Failure. J Nucl Med 42, 55-62 (2001).
- Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Using 10CO2 for Single Subject Characterization of the Stimulus Frequency Dependence in Visual Cortex: A Novel Positron Emission Tomography Tracer for Human Brain Mapping. J Cereb Blood Flow Metab 21`: 1003-12 (2001).
- DeJesus OT. Endres CJ. Shelton SE. Nickles RJ. Holden JE. Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo. Synapse. 39(1):58-63, (2001)
2000
- Nickles RJ, Jensen M, Paans AMJ, Holm S, Schueller MJ, Vaalburg W. Doppler Broadening Revealing the Chemical Environment Following Oxygen-14 Decay. Radiochimica Acta 88, 189-92(2000).
- DeJesus OT, Solin O, Haaparanta M, Nickles RJ. 6-FluoroDOPA Metabolism in Rad Striatum: Time Course of Extracellular Metabolites
- DeGrado TR, Wang S, Holden JE, Nickles RJ, Taylor MD, Stone CK. Synthesis and Preliminary Evaluation of 18F-labeled 4-Thia Palmitate (FTP) as a PET Tracer of Myocardial Fatty Acid Oxidation. Nucl Med and Biol 27, 221-231 (2000).
- Alves F, Jensen M, Jensen H, Nickles RJ, Holm S. Determination of the excitation function for the 10B(p,n)10C reaction and its implications for the production of [10C]CO2 for use as a steady state PET tracer. Int J Appl Rad Isotopes 54 (4), (2000), 899-903.
- DeJesus OT, Solin O, Haaparanta M, Nickles RJ. 6-FluoroDOPA Metabolites in Rat Striatum: Time Course of Extracellular and Intraneuronal Localization. Brain Research 877, 31-36 (2000).
- Oakes TR, Holden JE, Pyzalski RW, Roberts AD, Brown WD, Nickles RJ, Davidson RJ. Comparison of 2D and 3D PET for Cerebral FDG in Human Subjects. IEEE Trans Nucl Sci 47 (3), 1233-1241 (2000).
1999
- Roberts AD, Davidson RJ, Nickles RJ. Production of 17F, 15O and Other Radioisotopes for PET Using a 3 MV Electrostatic Tandem Accelerator. AIP Conference Proc. 475 (American Institute of Physics Press, Woodbury, NY) (1999) 1006.
- Brown WD, DeJesus OT, Pyzalski RW, Malischke LM, Roberts AD, Shelton SE, Uno H, Houser WD, Nickles RJ, Holden JE. Localization of Trapping of 6-[18F]fluoro-L-m-tyrosine, an Aromatic L-Amino Acid Decarboxylase Tracer for PET. Synapse 34, (1999), 111-123.
- Hochachka PW, Clark CM, Matheson GO, Brown WD, Stone CK, Nickles RJ, Holden JE. Effects on Regional Brain Metabolism of Prolonged High Altitude Hypoxia: A Study of Six US Marines. Am J Physiol 46, (1999) R314-R319.
- Brown WD, Taylor MD, Roberts AD, Oakes TR, Schueller MJ, Holden JE, Malischke LM, DeJesus OT, Nickles RJ. FluoroDOPA PET Shows the Non-Dopaminergic as well as Dopaminergic Destinations of Levodopa. Neurology 53, (1999), 1212-1218.
- DeJesus OT, Brown, WD, Shelton SE, Roberts AD, Nickles RJ, Holden JE. PET Studies in Rhesus Monkeys Using 6-Fluoro Meta-Tyrosine, and Aromatic L-Amino Acid Decarboxylase Tracer. J Lab Comp Radiopharm 42,(1999) S392-S394.
- Brown WD, DeJesus OT, Shelton SE, Uno H, Houser D, Nickles RJ, Roberts AD, Holden JE. Localization of the Trapping of [F-18]-6-fluoro-m-tyrosine, A Tracer of Monoamine Terminals for PET. Synapse 34 (2), (1999), 111-123.
- Johnson, T. K., Barnhart. T. An alternative to Monte Carlo in determining release criteria for patients administered radioactive material, Health Physics 1999; 77(6):724-726
- Haney, J. H., Barnhart, T. E., Zaidins, C. S. Extraction of neutron spectral information from Bonner-Sphere data, Nucl Inst Meth A 1999; 431(3):551-555
1998
- Rehm KE, Jiang CL, Paul M, Blumenthal D, Daniel LA, Davids CN, Decrock P, Fischer SM, Henderson D, Lister C, Nickles J, Nolen J, Pardo RC, Schiffer JP, Seweryniak D, Segel RE. Study of Radiative Capture with Radioactive Ion Beams. Nucl Instr Methods A 418, (1998) 355-364.
- Brown WD, Oakes TR, DeJesus OT, Taylor MD, Roberts AD, Nickles RJ, Holden JE. Dosimetry for F-18 fluoro-L-DOPA with Carbidopa Pretreatment Using the MIRD Pamphlet 14 Bladder Model. J Nucl Med 39, 1884-92 (1998).
- Stone CK, Pooley RA, DeGrado TR, Renstrom B, Nickles RJ, Nellis SH, Liedtke AJ, Holden JE. Myocardial Uptake of the Fatty Acid Analog 14-Fluorine-18-Fluoro-6-Thia-Heptadecanoic Acid in Comparison to Beta-Oxidation Rates by Tritiated Palmitate. J Nucl Med 39, (1998) 1690-96.
- Wallhaus TR, Lacy J, Whang J, Green MA, Nickles RJ, Stone CK. Human Biodistribution and Dosimetry of the Perfusion Agent Copper-62 PTSM. J Nucl Med 39, (1998) 1958-64.
1997
- Rehm KE, Jiang CL, Paul M, Blumenthal D, Daniel, LC, Davids CN, DeCrock P, Fischer SM, Henderson D, Lister C, Nickles J, Pardo RC, Schiffer JP, Seweryniak D, Segeel RE. The Influence of the 18F(p,α)19Ne Reaction on the Breakout from the Hot CNO Cycle. Nuclear Physics A 621 (1997) C115.
- Rehm KE, Paul M, Roberts AD, Jiang CL, Blumenthal D, Davids CN, Decrock P, Fischer SM, Gehring G, Henderson D, Lister CJ, Nickles RJ, Nolen J, Pardo RC, Schiffer JP, Segel RE. Nuclear Reaction Studies with Radioactive F-18 Beams at ATLAS. Nuclear Physics A 616, (1997) C115.
- Rehm KE, Jiang CL, Paul M, Blumenthal D, Daniel, LC, Davids CN, DeCrock P, Fischer SM, Henderson D, Lister C, Nickles J, Nolen J, Pardo RC, Schiffer JP, Seweryniak D, Segel RE. Exploring the 18F(p,α)19 Ne Gateway to the Formation of Heavy Elements in Hot Stars. Phys Rev Letters 55, R566-9, 1997.
- DeJesus OT, Endres CJ, Shelton SE, Nickles RJ, Holden JE. Evaluation of Fluorinated m-Tyrosine Analogs as PET Imaging Agents of Dopamine Nerve Terminals: Comparison with 6-FluoroDOPA. J Nucl Med 38, 630-5 (1997).
- Nickles RJ, Kulago AA, Schueller MJ, Stone CK. A Rather Intense Source of Fast Neutrons for Small Scale Activation. J Appl Radiat Isotopes 48, (1997) 55.
- DeJesus OT, Lefeber PA, Chyan M-K, Nickles RJ. Synthesis of F-18 - a - Fluoro Methyl Phenylalanine: A Potential Tyrosine Hydroxylase Tracer. J Lab Comp Radiopharm 40, (1997) 674-676.
- Taylor MD, Nickles RJ. F-18 Halothane Photolabeling of Isolated Proteins. J Lab Comp Radiopharm 40, (1997) 11-14.
- Nickles RJ, Taylor MD, Mulnix TL, Roberts AD, Schueller MJ, Kulago AA, DeJesus OT, Brown WD, Whitesell LF, Carlson KC, Stone CK. Achieving Balanced Resolution in Radiopharmacological Studies: Tc-Labeled BMS 194,796. J Lab Comp Radiopharm 40, (1997) 139-142 .
1996
- Rehm KE, Paul M, Roberts A, Blumenthal D, Gehring J, Henderson D, Jiang CL, Nickles J, Nolen J, Pardo RC, Schiffer JP, Segel RE. The Astrophysical Reaction Rate for the 18F(p,α)15O Reaction. Phys Rev C 53 (1996),438.
- Taylor M, Roberts AD, Nickles RJ. Improving the Yield of 2FDG Using a Microwave Cavity. Nucl Med Biol 23 (1996) 605.
- Hochachka PW, Clark CM, Monge C, Stanley C, Brown WD, Stone CK, Nickles RJ, Holden JE. Sherpa brain glucose metabolism and defense adaptations against chronic hypoxia. J Appl Physiol 81, 1355-61 (1996).
- Rehm KE, Jiang CL, Paul M, Blumenthal D, Gehring J, Henderson D, Nickles J, Nolen J, Pardo RC, Roberts AD, Schiffer JP, Segel RE. The Use of a Gas-Filled Magnet in Experiments with Radioactive Ion Beams. Nucl Instr Methods A 370 (1996) 438.
- Tewson TJ, Yang D, Wong G, Macy D, DeJesus OJ, Nickles RJ, Perlman SB, Taylor MD, Frank P. The Synthesis of F-18 Lomefloxacin and Its Preliminary Use in Human Studies. Nucl Med Biol 23 (1996) 767-72.
- Nickles RJ, de Jesus OT. Truly Frugal PET: Is it Possible? J Am Chem Soc Suppl.
1995
- Martin CC, Christian BT, Satter MR, Nickerson LDH, Nickles RJ. Quantitative PET with Positron Emitters That Also Emit Prompt Gamma Rays. IEEE Trans Medical Imaging 14, 681-8 (1995).
- Gunther I, Psylla M, Reddy GN, Antonini A, Reist HW, Zollinger A, Nickles RJ, Leenders KL. PET in Drug Evaluation: Influence of three Different COMT Inhibitors on peripheral [NCA] 6-18F Fluoro-L-dopa Metabolism in Rhesus monkey. Int J Nucl Med Biol 22, 921-927 (1995).
- Christian BT, Nickles RJ, Stone CK, Mulnix TL, Clark J. Improving the Radionuclidic Purity of Tc-94m for PET Imaging. Int J Appl Rad Isotopes 46, 69-73 (1995).
- Roberts AD, Oakes TR, Nickles RJ. Development of an improved target for [F-18]F2 production. Int J Appl Rad Isotopes 46, 87-91 (1995).
- Stone CK, Mulnix T, Nickles RJ, Renstrom B, Nellis SH, Liedtke AJ, Nunn AD, Kuczynski BL, Rumsey WL. Myocardial Kinetics of a Putative Hypoxic Tissue Marker, Technetium-99m Labeled Nitroimidazole (BMS-181321), after Regional Ischemia and Perfusion. Circulation 92, 1246-53 (1995).
- Roberts AD, Daniel LC, Nickles RJ. A High Power Target for the Production of [F-18]-fluoride. Nucl Instr Methods 99. 797-799 (1995).
- Rehm KE, Paul M, Roberts AD, Blumenthal, Gehring J, Henderson D, Jiang CL, Nickles J, Nolen J, Pardo RC, Schiffer JP, Segel RE. Study of the 18F(p,a)15O Reaction at Astrophysical Energies using a 18F beam. Phys Rev C 52 (1995) R460-3.
- Roberts AD, Nickles RJ, Paul M, Rehm KE, Jiang CL, Blumenthal DJ, Gehring J, Hernderson D, Nolen J, Pardo RC, Schiffer JP, Segel RE. Production of a Radioactive F-18 Ion Beam for Nuclear Reaction Studies. Nucl Instr Methods B.103, (1995) 523.
- Taylor MD, Mulnix TL, Roberts AD, Andreaco MS, Williams CW, Nickles RJ. PETite: A Tomographic Test Bench. IEEE Trans Nucl Sci, Supp 1 (1995) 65.
- Nickles RJ, Mulnix TL, Christian BT, Stone CK, Nunn AD. A Triple Isotope Technique to Study the Radiopharmacology of Technetium Agents. J Lab Comp Radiopharm 37, 726-9 (1995).
- DeJesus OT, Murali D, Nickles RJ. Synthesis of Brominated and Fluorinated ortho-Tyrosine Analogs as Potential DOPA Decarboxylase Tracers. J Lab Comp Radiopharm 37, 147-9 (1995).
- Holden JE, Stone CK, Clark CM, Brown WD, Nickles RJ, Hochachka PW: Enhanced Cardiac Metabolism of Plasma Glucose in High-Altitude Natives: Adaptation against Chronic Hypoxia. J Appl Physiol 79, 228-38 (1995).
- Taylor MD, Mulnix TL, Roberts AD, Andreaco MS, Williams CW, Nickles RJ. PETite: a Tomographic Test Bench. IEEE Trans Nucl Sci , Suppl 1, (1995) 65-8.
1994
- Satter MR, Martin CC, Oakes TR, Christian BT, Nickles RJ. Synthesis of the Fluorine-18 Labeled Inhalation Anesthetics. Int J Appl Rad Isotopes 45, 1093-1100, (1994).
- Levine RL, Hanson JM, Nickles RJ. Cerebral Vasocapacitance in Human Aging. J Neuroimaging 4, 130-136, (1994).
- Hochachka PW, Clark CM, Brown WD, Stanley C, Stone CK, Nickles RJ, Zhu GG, Allen PS, Holden JE. The brain at high altitude: Hyupometabolism as a defense against chronic hypoxia? J Cereb Blood Flow Metab 14: 671-679, 1994.
- Stone CK, Christian BT, Nickles RJ, Perlman SB. Technetium-94m Methoxy Isobutyl Isonitrile: Dosimetry and Resting Cardiac Imaging with Positron Emission Tomography. J Nucl Cardiol 1, 425-33 (1994).
- Hochachaka PW, Clark CM, Brown WD, Stanley C, Stone CK, Nickles RJ, Zhu G, Allen PS, Holden JE. The Brain at High Altitude: Hypometabolism as a Defense Against Chronic Hypoxia? J Cereb Bl Flow Metab 14: 671-679 (1994).
- Tewson TJ, Yang D, Wong G, Macy D, DeJesus OT, Nickles RJ, Perlman SB, Taylor M, Frank P. F-18 Lomefloxacin: Human in vivo Pharmacokinetic Studies Using Fluorine-18 Labeled Drugs. J Lab Comp Radiopharm 35, 559, (1994)
- DeJesus OT, Murali D, Oakes TR, Kitchen R, Holden JE, Nickles RJ. Enzyme Activated Trapping as a Mechanism for Developing PET Tracers of Neurotransmission. J Lab Comp Radiopharm 35, 452, (1994).
- Nickles RJ, Christian BT, Mulnix TL, Stone CK. Quantitating Technetium Pharmacokinetics with PET, SPECT and Beta Spectroscopy. J Lab Comp Radiopharm 35, 22-25, (1994).
- DeJesus OT, Murali D, Kitchen R, Endres CJ, Oakes TR, Shelton SE, Freund L, Houser WD, Uno H, Holden JE, Nickles RJ. Evaluation of 3[F-18]Fluoro-a-Fluoromethyl-p-Tyrosine, a Potential PET Tracer of Tyrosine Hydroxylase Activity. Nucl Med Biol 21, 663-667 (1994).
1993
- DeJesus OT, Murali D, Kitchen R, Oakes TR, Nickles RJ. Direct Synthesis of 3-Fluoro-a-Fluoromethyl-p-Tyrosine. J Fluorine Chem 65, 73-77 (1993).
- Rozental JM, Levine RL, Levin, AB, Nickles RJ. Dexamethasone and Brain Tumor Glucose Uptake. J Neuroimaging 3: 6-10, (1993).
- Nickles RJ, Nunn AD, Stone CK, Christian BT. Technetium-94m-Teboroxime: Synthesis, Dosimetry and Initial PET Imaging Studies. J Nucl Med 34, 1058-1066, (1993).
- Levine RL, Brooks BR, Matthews CG, Rosenbeck JC, Hartmann HA, Nickles RJ. Fronto temporal Hypometabolism in Amyotrophic Lateral Sclerosis - Dementia Complex. J NeuroImage 3, 234-241 (1993)
- DeJesus OT, Murali D, Oakes TR, Holden JE, Nickles RJ. Synthesis of [F-18]-Labeled a-Fluoromethyl p-Tyrosine, A Tyrosine Hydroxylase-Activated Decarboxylase Suicide Inhibitor with Potential as an Imaging Agent for Dopamine Nerve Termminals. J Label Comp Radiopharm 32, 260-261 (1993).
1992
- Levine RL, Rozental JM, Nickles RJ. Blood Flow Asymmetry in Carotid Occlusive Disease. Angiology 43, 100 (1992).
- Nickles RJ, Solin OH. A Wide-Range Flexible Gamma Probe. Appl Radiat Isotopes 43, 1169 (1992).
- Murali D, DeJesus OT, Sunderland JJ, Nickles RJ. F-19 Fluoro-β-fluoromethylene-m-tyrosine Analogs, Potential PET Agents for Presynaptic Dopamine Terminal: Synthesis and Spectroscopic Characterization. Appl Radiat Isotopes 43, 969 (1992).
- Nickles RJ, Solin OH, Harparaanta M, DeJesus OT. A Flow-Through Detector for Nano-Curie Activities Encountered in HPLC Analysis of PET Tracer Metabolites. IEEE Trans Nucl Sci. 39: 2316-2321, (1992).
- Rozental JM, Cohen BT, Mehta M, Levine RL, Hanson J, Nickles RJ, Levin AL. Acute Changes in Glucose Metabolism After Treatment: The Effects of Carmustine (BCNU) on Human Glioblastoma Multiforme. Journal of Neuro-Oncology.
- DeJesus OT, Holden JE, Endres C, Murali D, Oakes TR, Shelton S, Uno H, Houser D, Freund L Perman SB, Nickles RJ. Visualization of Dopamine Nerve Terminals by Positron Emission Tomography Using F-18 Fluoro-methylene-m-Tyrosine. Brain Research 597: 151-154, (1992).
- DeJesus OT, Holden JE, Murali D, Uno H, Shelton S, Houser D, Freund L, Perlman SB, Nickles RJ. Positron Emission Tomography of [F-18]-6-F-(E)-b-Fluoromethylene -DL-Meta-Tyrosine (MDL 72394) in Rhesus Monkeys. Nucl Med Biol, Int J Radiat Appl Instr 19: 135-136 (1992).
1991
- Rozental JM, Levine RL, Mehta MP, Kinsella TJ, Levin AB, Algan O, Mendoza M, Hanson JM, Schrader DA, Nickles RJ. Early Effects in Tumor Metabolism after Treatment: The Effects of Stereotactic Radiotherapy. Int J Radiation Oncology, Biology, Physics 20: 1053-1060, (1991).
- DeJesus OT, Murali D, Chen C-A, Sunderland JJ, Weiler M, Nickles RJ. F-18 Labelled PET Tracers for CNS Presynaptic Dopamine Receptors. J Label Comp Radiopharm.30, 272 (1991).
- DeJesus OT, Solin O, Haaparanta M, Chen C-A, Murali D, Sunderland JJ, Nickles RJ. Evaluation of F-18 labelled Dopamine Receptor Tracers Using in Vivo Microdialysis. J Label Comp Radiopharm 30, 290 (1991).
- Solin O, Haaparanta M, Sunderland JJ, DeJesus OT, Nickles RJ. Subnanocurie HPLC Analysis of Labelled Metabolites with a Flow-through-β+-Detector. J Labelled Comp Radiopharm. 30, 305 (1991).
- Sunderland JJ, DeJesus OT, Solin O, Nickles RJ. Electrophilic F-18 from an 11 MeV Proton Cyclotron for the Radiolabelling of Presynaptic Dopaminergic Tracers. J Label Comp Radiopharm 30, 92 (1991).
- Nickles RJ. Production of a Broad Range of Radionuclides with an 11 MeV Proton Cyclotron. J Label Comp Radiopharm 30, 120 (1991).
- Perlman SB, Blood KMT, Sackett JF, Balliet R, Lazarus JK, Wilson MA, Sunderland JJ, Nickles RJ. Anatomic and Functional Changes Associated with Crossed Cerebellar Diaschisis in Chronic Brain Injured Subjects. J Neuro Rehab 5, 1 (1991).
- Satter MR, Nickles RJ. Proposed Carbanion Formation in the Exchange Reaction of the F-18 Labeled Inhalation Anesthetics. J Label Comp Radiopharm 30, 58 (1991).
- Levine RL, Dobkin JA, Rozental JM, Satter MR, Nickles RJ. Blood Flow Reactivity to Hypercapnia in Strictly Unilateral Carotid Disease: Preliminary Results. J Neuro Neurosurg Psych 54: 204-209, (1991)
1990
- Rozental JM, Levine RL, Nickles RJ. Early Changes in Glioma Metabolism After Treatment: Prognostic Significance. J Neuro-Oncology 10: 75-83, (1990).
- DeJesus OT, Sunderland JJ, Nickles RJ, Mukherjee J, Appelman, EH. Synthesis of Radiofluorinated Analogs of m-Tyrosine as Potential L-Dopa Trascers via Direct Reaction with Acetylhypofluorite. Int J Appl Rad Isotopes 41: 433 (1990)
- DeJesus OT, Nickles RJ. Production and Purification of Zr-89, a Potential PET Antibody Label. Int J Appl Rad Isotopes 41: 789 (1990).
- DeJesus OT, Sunderland JJ, Nickles RJ. Stability of 18F-6-Fluoro- L-DOPA. Nucl Med 31, 2076 (1990).
- Votaw JR, Satter MR, Nickles RJ. Oxygen Present During the Azeotropic Drying Drastically Reduces Radiochemical Yield of 2-FDG. J Label Comp Radiopharm 23, 83 (1990).
- Rozental JM, Levine RL, Nickles RJ, Dobkin JA, Hanson JM. Cerebral Diaschisis in Patients with Malignant Glioma. J Neuro-Oncology 8: 153 (1990).
- Zupanc ML, Handler EG, Levine RL, Jahn TW, ZuRhein GM, Rozental JM, Nickles RJ, Partington CR. Rasmussen Encephalitis: Epilepsia Partialis Continua Secondary to Chronic Encephalitis. Pediatric Neurology 6, 397-401, (1990).
1989
- Rozental JM, Levine RL, Nickles RJ, Dobkin JA: Glucose Uptake by Gliomas after Chemotherapy: A Positron Emission Tomographic Study. Arch Neurol 46: 1302-1307, (1989).
- Levine RL, Lagreze HL, Dobkin JA, Hanson, Satter MR, Rowe BR, Nickles RJ: Cerebral Vasocapacitance and TIA's. Neurology 39, 25 (1989).
- Nickles RJ, Satter MR, Votaw JR, Sunderland JJ, Martin CC: The Synthesis of Potent Anesthetics, J Labeled Compounds Radiopharm. 26: 448 (1989).
- Votaw JR, Nickles RJ. Radionuclide Production for Positron Emission Tomography: Choosing an Appropriate Cyclotron. Nucl Instr Meth B40, 1093 (1989).
- Dobkin JA, Levine RL, Lagreze HL, Dulli DA, Nickles RJ, Rowe BR. Evidence for Transhemispheric Diaschisis in Unilateral Stroke. Archives of Neurol 46, 1302 (1989).
- Rozental JM, Levine RL, Nickles RJ, Dobkin JA. Glucose Uptake by Gliomas After Treatment: A Positron Emission Tomographic Study. Arch Neurol 46: 1302 (1989).
- Votaw JR, Nickles RJ. A Theoretical Description of the Beam Induced Heating of Accelerator Target Foils. Nucl Inst Meth A281: 216, (1989).
- Renstrom B, Rommelfanger S, Stone CK, DeGrado TR, Carlson KJ, Scarbrough E, Nickles RJ, Liedtke AJ, Holden JE. Comparison of Fatty Acid Tracers FTHA and BMIPP During Myocardial Ischemia and Hypoxia. J Nucl Med 39, (1998) 1684-89.
1988
- Levine RL, Sunderland JJ, Lagreze HL, Nickles RJ, Rowe BR, Turski PA: Cerebral Perfusion Reserve Indices as Determined by Fluoromethane Positron Emission Scanning. Stroke 19, 19-27, (1988).
- Levine RL, Lagreze HL, Berkoff HA, Turnipseed WP, Hanson JM, Sunderland JJ, Rowe BR, Nickles RJ: Non-invasive Testing of Cerebral Perfusion Reserve Prior to Coronary Artery Bypass Graft Surgery. Angiology 39: 421-428, (1988).
- Lagreze HL, Levine RL, Sunderland JJ, Ludicke J, Nickles RJ: Pitfalls of Regional Cerebral Blood Flow Analysis in Cerebrovascular Disease. Clin. Nuc. Med. 13, 197-201, (1988).
- Votaw JR, Nickles RJ, Martin CC: Optimal Detector Geometry to Maximize Light Output and Timing Characteristics of Fast Scintillators. IEEE Trans. Nucl. Science NS-35: (1), 712, (1988).
1987
- Rosenthal MS, DeLuca PM, Pearson DW, Nickles RJ: An In Vivo Technique for the Measurement of Bone Blood Flow in Animals. Phys Med Biol 32: 453 (1987).
- Votaw JR, Satter MR, Sunderland JJ, Martin, CC, Nickles RJ: Wide Range Neutron Counting for Yield Prediction of PET Agents in Cyclotron Irradiations. IEEE Trans Nucl Sci NS-34, 277 (1987).
- Lagreze HL, Levine RL, Pedula KL, Nickles RJ, Sunderland JJ, Rowe BR: Contralateral Flow Reduction in Unilateral Stroke: Evidence for Transhemispheric Diaschisis. Stroke 18, 882-886, (1987).
1986
- Daube ME, Nickles RJ: Development of Myocardial Perfusion Tracers for Positron Emission Tomography. Int J Nucl Med Biol 12, 303-314 (1986).
- Hutchins GD, Hichwa RD, Koeppe RA, Ehrenkaufer RL, Rothley JM, Votaw JR, Rosenthal MS, Nickles RJ: A Dynamic Technique for the Simultaneous Estimation of Cerebral Metabolic Rate and Blood Flow Using Oxygen-15 and Positron Emission Tomography. J Cerebral Blood Flow and Metab.
- Levine RL, Sunderland JJ, Rowe BR, Nickles RJ: The Study of Cerebral Ischemic Reversibility: Part II. Fluoromethane Positron Emission Tomographic Determination of Perfusion Reserve in Patients with Carotid TIA and Stroke; Preliminary Preoperative Results. Am J Physiologic Imaging 1:104-114 (1986).
- Madsen MT, Nickles RJ: An Accurate Method for Correcting Count Rate Losses in Scintillation Cameras. Med Phys 13, 344 (1986).
- Votaw JR, Nickles RJ, Meyer HO, Hutchins GD, Satter MR: One-Nanosecond Overlap Coincidence Counting to Track PET Agents Over Six Decades. IEEE Trans Nucl Science NS-33, 486 (l986).
- Nickles RJ, Gatley SJ, Votaw JR, Kornguth ME: Production of Reactive F-18. Int J App Radiation Isotopes 37: 649 (1986).
1985
- Koeppe RA, Holden JE, Polcyn RE, Nickles RJ, Hutchins, GD, Weese JL: Quantitation of Local Cerebral Blood Flow and Partitions Coefficient Without Arterial Sampling: Theory and Validation. J Cereb Blood Flow Metab 5, 214-223 (1985).
- Rosenthal MS, RJ Nickles: Selected Noble Gas Partition Coefficients. Phys Med Biol 3, 945-950 (1985).
- Rosenthal MS, Bosch AL, Nickles RJ: Synthesis and Some Characteristics of No-Carrier Added 18F -Fluorotrimethylsilane. Int J Applied Rad Isotopes 30, 1145 (1985).
- Hutchins LG, Bosch AL, Rosenthal MS, Nickles RJ, Gatley SJ: On the Synthesis of 18F -2-deoxy-~2-fluoro~-D-glucose via 18F -fluoro trimethyl silane and 18F -tetra ethyl ammonium fluoride. Int J Applied Rad Isotopes 36: 375 (1985).
- Nickles RJ, Votaw JR: An Extended Range Well Counter. IEEE Trans Nucl Sci NS-32 (1), 60 (1985).
- Hutchins GD, Votaw JR, Funk KM, Rosenthal MS, Nickles RJ: Multigated Time-of-Flight Arterial Blood Sampling. IEEE Trans Nucl Sci NS-32: (1), 835 (1985).
- Nickles RJ, Hutchins GD, Votaw JR, Rosenthal MS: Target Telemetry for Medical Isotope Production. Nucl Instr Meth B10/11, 957-962 (1985).
1984
- Nickles RJ, Daube ME, Ruth TJ. An 18O2 Target for the Production of 18F2, Int. J. Appl. Rad. Isotopes 35, 117, (1984).
- Polcyn RE, Rowe B, Celesia GG, Nickles RJ, Koeppe RA, Holden JE: PET / Fluoromethane Assessment of rCBF: CO2 Reactivity Data and Its Analysis. J Cerebral Blood Flow and Metab. 3, S628, (1983).
- Rao N, Turski PA, Polcyn RE, Nickles RJ Matthews CG, Flynn MM: 18F Positron Emission Computed Tomography in Closed Head Injury. Arch Physical Medicine and Rehab 65, 780, (1984).
- Celesia GG, Polcyn RE, Holden JE, Nickles RJ, Koeppe RA, Gatley SJ. Determination of regional cerebral blood flow in patients with cerebral infarction: Use of fluoromethane labeled with fluorine-18 and positron emission tomography Arch Neurol 41, 262-267, 1984.
- Hutchins GD, Holden JE, Koeppe RA, Halama JR, Gatley SJ, Nickles RJ: Alternative Approach to Single Scan Estimation of Cerebral Glucose Metabolic Rate Using Glucose Analogs with Particular Application to Ischemia. J Cerebral Blood Flow and Metab 4: 35-40(1984).
1983
- Nickles RJ, Hichwa RD, Daube ME, Hutchins GD, Congdon, DD: An 18O 2 Target for the High Yield Production of 18F Fluoride. Int. J. Appl. Rad. Isotopes 34, 625, (1983).
- Nickles RJ, Daube ME, Hutchins GD. Smaller, Colder Targets. J. Labelled Comp. Radiopharm. 11, 1365, (1983).
- Celesia GG, Polcyn RE, Holden JE, Nickles RJ, Koeppe RA, Gatley SJ: 18F -Fluoromethane Positron Emission Tomography Determination of Regional Cerebral Blood Flow in Cerebral Infarction. J Cerebral Blood Flow and Metab 3, S23, (1983).
- Hutchins GD, Nickles RJ: Impulse-Response Measurement of rCBF and rCMRO2 Using Oxygen-15 and Positron Emission Tomography. J Cerebral Blood Flow and Metab 3, S121, (1983).
1982
- Gatley SJ, Hichwa RD, Shaughnessy WJ, Nickles RJ: 18F -Labelled Lower Fluoroalkanes; Reactor-Produced Gaseous Physiological Tracers. Int J Appl. Rad. Isotopes 32: 211-214 (1981).
- Nickles RJ. Special Purpose Time-of-Flight Techniques. IEEE Trans. Nucl. Sci. 29: 7, (l982).
- Celesia GG, Polcyn RE, Holden JE, Nickles RJ, Gatley SJ, Koeppe RA: Visual Evoked Potentials and PET Mapping of Regional Cerebral Blood Flow and Cerebral Metabolism. Can the New and Potential Generators be Visualized? Electroencephologr. Clin. Neurophysiol 54,243, (1982).
1981
- Shaughnessy WJ, Gatley SJ, Hichwa RD, Lieberman LM, Nickles RJ: Aspects of the Production of 18F-2-Fluoro-2-Deoxyglucose via 18F2 with a Tandem Van de Graaf Accelerator. Int. J. Appl. Rad. Isotopes 32: 2329 (1981).
- Madsen MT, Hichwa RD, Nickles RJ: An Investigation of 11C -methane, 13N -nitrous oxide and 11C -acetylene as Regional Cerebral Blood Flow Agents. Phys. Med. Biol. 26: 875 (1981).
- Hichwa RD, Daube ME, Nickles RJ: Small-scale Targetry for the production of 81Rb and 51Mn. J. Labelled Comp. Radiopharm. 10: 287 (1981).
- Hichwa RD, Nickles RJ, Targetry for the Production of Medical Isotopes, IEEE Trans. Nucl. Sci. 28: 1924 (1981).
- Holden JE, Gatley SJ, Hichwa RD, Ip WR, Shaughnessy W, Nickles RJ, Polcyn RE, Cerebral Blood Flow Using PET Measurements of Fluoromethane Kinetics. J Nucl Med 22: 1084, (1981).
- Celesia GG, Holden JE, Polcyn RE, Nickles RJ, Gatley SJ. 18F -Fluoromethane PET to Study Regional Blood Flow in Cerebral Infarction. Trans. Am. Neurol. Assn., 336, (1981).
1980
- Lieberman LM, Wiley AL, Wessels BW, Gatley SJ, Nickles RJ, Young D, Wolbert WH: F-18 5-Fluorouracil Studies in Humans and Animals. Int. J. of Rad. Oncology 6: 505-509 (1980).
- Nickles RJ: A High-Pressure Gas Target for Cyclotrons. Nucl. Instr. Meth. 177: 593-594 (1980).
1979
- Nickles RJ and Hichwa RD: A Digital Leaky Integrator. Nucl Instr Meth, 158: 609-610 (1979).
- Nickles RJ: A Dynamic Phantom for Nuclear Cardiology. J Nucl. Med. 20: 547-551 (1979).
- Nickles RJ, Gatley SJ and Madsen MT: High Yield Synthesis of the Sequence 13N2, 13N2O, 11C2H2, H214O, H215O and 17F- for rCBF Studies. J Labelled Compounds XVI; 90-92 (1979).
- Gatley SJ, Crawford JS and Nickles RJ: Synthesis of 11C -Hippuric Acid from 11C -Benzoic Acid and Glycine Using Rat Liver Mitochondria. J. Labelled Compounds XVI: 182-185 (1979).
- Hichwa RD and Nickles RJ: The Tuned Pipeline-A Link Between Small Accelerators and Nuclear Medical Needs. IEEE Trans. Nucl. Sci. 26: 1707-1709 (1979).
1978
- Nickles RJ, Meyer HO: Design of a Three-Dimensional Positron Camera for Nuclear Medicine. Phys. Med. Biol. 23: 686 (1978).
- Nickles RJ, Kiuru AJ, Schuster SM and Holden JE: A Catalytic Generator for the Production of H214O and H215O. Prog. Nucl. Med. 4:72 (1978).
- Nickles RJ, Gatley SJ, Hichwa RD, Simpkin DJ and Martin JL: Synthesis of 13N-Labelled Nitrous Oxide. Int. J. Appl. Rad. Isotopes 29: 225 (1978).
- Paans AMJ, Nickles RJ, de Graaf EJ and Vaalburg W, et al.: A Dual-Head Anger Camera for the Imaging of Positron-Emitting Radionuclides. Int. J. Nucl. Med. Biol., 5:266 (1978).
- Gatley SJ, Milkowski AL, Nickles RJ and Holden JE: Investigation of the Use of H215O to Estimate Lypolysis and Acyl-CoA Hydrolysis. Int J Appl. Rad. Isotopes, 29: 694-695 (1978).
1977
- Holden JE, Nickles RJ, Kiuru AJ, Polcyn RE: The Use of a Generalized Modular Data Handling System in Nuclear Medicine. Radiol. 122, (1977) 411.
- Polcyn RE and Nickles RJ: Experimental Approaches to Myocardial Function Studies. Sem. Nucl. Med. 7:101, (1977).
1976
- Nickles RJ, Holden JE, Kiuru AJ and Polcyn RE: Inclusion of Physiological Data into Computerized Nuclear Medicine Dynamic Studies. J. Nucl. Med. 17: 297 (1976).
1975
- Nickles RJ and Au YF: The Oxygen Clock, a Dual Tracer Physiological Timer. Physics in Medicine and Biology, Vol. 20, #1 (1975), 54.
1973
- Becchetti FD, Christensen PR, Manko VI, Nickles RJ: Ambiguities in Spectroscopic Factors Deduced from a DWBA Analysis of the (160,15N) Reaction. Physics Letters 43B: 279 (1973).
- Becchetti FD, Christensen PR, Manko VI, Nickles RJ: Elastic and Inelastic Scattering of 16,18 O and 12,13 C from Nuclei 40 < A < 96. Nuclear Physics A203: 1 (1973).
- Christensen PR, Manko VI, Becchetti GD, Nickles RJ: A Study of 16,18 O and 12,13 C Induced Reactions on 40 < A < 96 Nuclei. Nuclear Physics A207: 33 (1973).
1971
- Nickles RJ, Jollivette PL, Klody GM: Oxygen-Beryllium Neutron Tunneling Below the Coulomb Barrier. Akad Izvestia Nauk. 35 (1): (1971).
- Macfarlane RD, Oakey NS, Nickles RJ: Beta-Neutrino Correlations and Longitudinal Nuclear Alignment in the Decay of 20Na. Physics Letters 34B: 133 (1971).
- Nickles RJ, Manko VI, Christen PR, Becchetti FD: Study of One and Two Nucleon Transfer Reactions Induced by 16,18O-Ions Incident on the Even Zirconium Isotopes. Physical Review Letters 26: 1267 (1971).
- Manko VI, Becchetti FD, Christensen PR, Nickles RJ: Nuclear Transfer Reactions Induced by 16,18O-Ions on Nuclei in the f-p Shell. Journal de Physique Supp. 11-12, Vol. 32: 225 (1971).
1969
- Nickles RJ: Lifetimes in the 15 < A < 25 Mass Range. Nuclear Physics 134: 308 (1969).
1965
- Palmer DW, Mourad WC, Donhowe JM, Nielsen KE, Nickles RJ: Shape of (p,n) Yield Curves Near Threshold. Nuclear Physics 75: 515 (1965).
Patents
- US Patent #3,978,337: "A three-dimensional positron imaging device," R.J. Nickles and H.O. Meyer, (given to WARF).
- US Patent #4,033,335: "Multiplexing of physiological sensor signals with gamma ray camera data signals," R.J. Nickles, (given to WARF).
- US Patent #4,058,728: "A noise-modulated pulser for loss corrections in dynamic nuclear medicine studies," R.J. Nickles, (given to WARF).
- US Patent #4,631,410: "An extended range well counter, R.J. Nickles, (given to WARF).
- US Patent # 5,230,883: "Method for localization and treatment of tumors using polylysine complexes," S Kornguth, P Turski, I Robins, RJ Nickles (given to WARF).
- US Patent #6,410,919: "A Positron Gun for PET Attenuation Measurements," RJ Nickles (given to WARF)
- US Patent 6,585,953: "A Method to Produce F-17 Fluoroalkanes," AD Roberts and RJ Nickles (given to WARF)
- US Patent P04326US, "Systems and methods for the cyclotron production of Iodine-124," JA Nye and RJ Nickles (given to WARF), 2006.