In January of 2009, a GE PETrace cyclotron was installed in our new labs at the University of Wisconsin's Institutes for Medical Research. This 16 MeV proton, 8 MeV deuteron jewel is General Electric's 144th such machine. All targets and delivery systems are homemade. Research, clinical and automated syntheses of a wide variety of compounds with over a dozen radionuclides are now routine. A National Electrostatics Corportation beamline with tuning quadropole magnets affords an additional (net) 4 target ports, online beam profiling, and downward directed beam for irradiation of molten targets.
Our GE PETrace
The first CTI RDS 112, an 11 MeV proton cyclotron, was installed at the University of Wisconsin Medical Physics Department in 1985. Since that time, it has performed with distinction with less than 1% downtime and literally hundreds of patient scans and radionuclides produced to its credit. Operating under a fair-share cost-recovery ("128-account"), the cyclotron has provided a major resource for basic researchers, student training and PET clinicians alike from across campus to around the world. The modifications that make this first RDS unique include:
- a vertical switching magnet, deflecting the beam straight down for the irradiation of molten targets
- a plethora of specialty targets for the production of such unusual radionuclides as carbon-10, oxygen-14, electrophilic fluorine-17 and more than a hundred proton-rich reaction products
- a wide variety of neutron and gamma detectors that monitor the progress of the irradiation.
Our Old CTI RDS 112 Cyclotron
The Radiochemistry Labs
WIMR Labs: Our updated facility includes dual Capintec hot cells filled with Scansys automated research chemistry synthesis units as well as 2 fume hoods, an electronics lab, 5 HPLC systems, dedicated facilities intended for careful progression towards cGMP standards of radioisotope production, two GC systems, dedicated space for metabolite analysis and an electronics workshop.
Inside one of our new hot cells
MSC Labs: The fully equipped radiochemistry labs cover about 4000 square feet, with a full complement of 5 fume hoods, which are set up for Curie level synthesis. Fast flow-through reactors perform gas-phase reactions in seconds. Analytic equipment includes HPLC (8 systems), GC (2), TLC and X-ray fluorescent spectrometry. In vivo micro-dialysis permits real-time sampling and radiochemical analysis of the extra cellular fluid space in rats, tracking labeled metabolites responding to pharmacological challenge.
The Cyclotron Jockey doing his thing
PET: A Siemens HR+ scanner is installed in space adjacent to our WIMR lab in March of 2009. In addition to this scanner, we regularly produce for or have access to an Inveon Small Animal Scanner, a GE Advance PET/CT, 2 additional HR+ scanners in the Waisman Labs, and a MicroPET scanner located in the Harlow Primate Research Center.
Autoradiography: Tissue-sectioning microtomes prepare slices for ex vivo autoradiography with a Packard Cyclone phosphor imaging system, capable of 40 μm spatial resolution over 5 decades of dynamic range.