Edward Jackson


Emeritus Professor



Department of Medical Physics
Wisconsin Institutes for Medical Research
1111 Highland Avenue, Room 1005
Madison, WI 53705


1990 – The University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Houston, TX, PhD, Biophysics

1986 – Auburn University, Auburn, AL, MS, Physics

1984 – Auburn University, Auburn, AL, BS, Physics

Board Certification

  • 4/1998 – American Board of Medical Physics – Magnetic Resonance Imaging Physics
  • 6/1996 – American Board of Radiology – Diagnostic Radiological Physics

Department Affilations

Medical Physics, Radiology, Human Oncology


Selected Current Extramural Positions

  • Chair – Quantitative Imaging Biomarkers Alliance of the Radiological Society of North America (RSNA QIBA)
  • Chair – Commission on Accreditation of Medical Physics Education Programs (CAMPEP)
  • Member and Past Chair – Ad Hoc Committee on Standards for Quantitative MR of the International Society for Magnetic Resonance in Medicine (ISMRM)
  • Member – Board of Directors of the Society of Directors of Academic Medical Physics Programs (SDAMPP)
  • Vice Chair – Education Council of the American Association of Physicists in Medicine (AAPM)
  • Member – American College of Radiology Committee on MR Safety and Commission on Research (ACR)
  • Member – Radiological Society of North America Committee on Scientific Affairs (RSHA)

Research Interests

  • Quantitative imaging biomarkers: development, implementation, validation
  • Functional magnetic resonance imaging and spectroscopy and applications in assessment of therapy

Awards and Honors

  • 2004 – Fellow, American Association of Physicists in Medicine (AAPM)
  • 2007 – MD Anderson Cancer Center William Randolph Hearst Foundations Faculty Achievement Award in Education
  • 2011 – Fellow, American College of Radiology (ACR)
  • 2012 – Election to the University of Texas Academy of Health Science Education / University of Texas Distinguished Teaching Professor


Selected Recent Publications

  • Jackson EF, Esparza-Coss E, Wen X, Ng CS, Daniel SL, Price RE, Rivera B, Charnsangavej C, Gelovani JG, Li C. Magnetic Resonance Imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids. Int J Radiat Oncol Biol Phys 68(3):830-8, 2007.
  • Orth RC, Bankson J, Price R, Jackson EF. Comparison of single- and dual-tracer pharmacokinetic modeling of dynamic contrast-enhanced MRI data using low, medium, and high molecular weight contrast agents. Magn Reson Med 58(4):705-16, 2007.
  • Puduvalli VK, Giglio P, Groves MD, Hess KR, Gilbert MR, Mahankali S, Jackson EF, Levin VA, Contrad CA, Hsu SH, Colman H, deGrott JF, Ritterhouse MG, Ictech SE, Yung WKA. Phase II trial of irinotecan and thalidomide in adults with recurrent glioblastoma multiforme. Neuro-oncology:216-222, 2008.
  • Hatiboglu MA, Weinberg JS, Suki D, Rao G, Prabhu SS, Shah K, Jackson E, Sawaya R. Impact of intraoperative high-field magnetic resonance imaging guidance on glioma surgery: a prospective volumetric analysis. Neurosurgery 64(6):1073-1081, 2009.
  • Herbst RS, Hong D, Chap L, Kurzrock R, Jackson E, Silverman JM, Rasmussen E, Sun YN, Zhong D, Hwang YC, Evelhoch JL, Oliner JD, Le N, Rosen LS. Safety, pharmacokinetic, and anti-tumor activity of AMG 386, a selective angioioietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 27(21):3557-3565, 2009.
  • Price MJ, Jackson EF, Gifford KA, Eifel PJ, Mourtada F. Development of prototype shielded cervical intracavitary brachytherapy applicators compatible with CT and MR imaging. Med Phys 36(12):5515-24, 2009.
  • Ma J, Jackson EF, Kumar AJ, Ginsberg LE. Improving fat-suppressed T2-weighted imaging of the head and neck with 2 fast spin-echo dixon techniques: initial experiences. Am J Neuroradiol (AJNR) 30(1):42-45, 2009.
  • Jackson, EF, Barboriak, DP, Bidaut, LM, Meyer, CR. MR assessment of response to therapy: tumor change measurement, truth data & error sources. Transl Oncol 2:211-215, 2009.
  • Perrier, ND, Balachandran, D, Wefel, JS, Jimenex, C, Busaidy,N, Morris, GS, Dong, W, Jackson, EF, Weaver, S, Gantela, S, Evans, DB, Grubbs, EG, Lee, JE. Prospective, randomized, controlled trial of parathyroidectomy versus observation in patients with “asymptomatic” primary hyperparathyroidism. Surgery 146:1116-1122, 2009.
  • Meyer, CR, Armato III, SG, Fenimore, CP, McLennan, G, Bidau, LM, Barboriak, DP, Gavrielides, MA, Jackson, EF, McNitt-Gray, MF Kinahan, PE, Petrick, N. Zhao, B. Quantitative imaging to assess tumor response to therapy: common themes of measurement, truth data and error sources. Transl Oncol 2:198-210, 2009.
  • Ng CS, Raunig DL, Jackson EF, Ashton EA, Kelcz F, Kim KB, Kurzrock R, McShane TM. Reproducibility of perfusion parameters in dynamic contrast-enhanced MRI of lung and liver tumors: effect on estimates of patient sample size in clinical trials and on individual patient responses. AJR Am J Roentgenol 194(2):W134-40, 2010.
  • Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC, Hugo JW, Aerts HJ, Bendriem B, Bendsten C, Boellaard R, Boone JM, Burstein D, Cole PE, Conklin JJ, Dorfman GS, Douglas PS, Eidsaunet W, Elsinger C, Frank RA, Gatsonis C, Giger ML, Gupta SN, Gustafson D, Hoekstra OS, Jackson EF, Karam L, Kelloff GH, Kinahan PE, McLennan G, Miller CG, Mozley PD, Muller KE, O’Donnell K, Patt R, Raunig D, Rosen M, Rupani H, Schwartz LH, Siegel BA, Sorensen AG, Wahl RL, Waterton JC, Wolf W, Zahlmann G, Zimmerman B. A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging. Radiology 258(3):906-914, 2011.
  • Versace FV, Engelmann JM, Jackson EF, Costa VD, Robinson JD, Lam CY, Minnix JA, Brown VL, Cinciripini PM. Do brain responses to emotional images and cigarette cues differ? An fMRI study in smokers. Eur J Neurosci 34(12):2054-2063, 2011.
  • Le-Petross HT, Cristofanilli M, Carkaci S, Krishnamurthy S, Jackson EF, Harrell RK, Reed BJ, Yang WT. MRI features of inflammatory breast cancer. Am J Roentgenol 197(4):W769-W776, 2011.
  • Tian M, Wen X, Jackson EF, Ng C, Uthamanthil R, Liang D, Gelovani JG. Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study. Contrast Media Mol Imaging 6(4):289-297, 2011.
  • Coleman RL, Duska LR, Ramirez PT, Heymach JV, Kamat AA, Modesitt SC, Schmeler KM, Iyer RB, Garcia ME, Miller DL, Jackson EF, Ng CS, Kundra V, Jaffe R, Sood AK. Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. Lancet Oncol 12(12):1109-1117, 2011.
  • de Groot JF, Lamborn KR, Chang SM, Gilbert MR, Cloughesy T, Aldape K, Yao J, Jackson EF, Lieberman F, Robins HI, Mehta MP, Lassman AB, DeAngelis LM, Yung WKA, Chen A, Prados MD, Wen PY. Phase II study of aflibercept (VEGF trap) in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol 29(19):2689-2695, 2011.
  • Buckler AJ, Bresolin L, Dunnick NR, Sullivan DC, Aerts HJ, Bendriem B, Bendsten C, Boellaard R, Boone JM, Cole PE, Conklin JJ, Dorfman GS, Douglas PS, Eidsaunet W, Elsinger C, Frank RA, Gatsonis C, Giger ML, Gupta SN, Gustafson D, Hoekstra OS, Jackson EF, Karam L, Kelloff GH, Kinahan PE, McLennan G, Miller CG, Mozley PD, Muller KE, Patt R, Raunig D, Rosen M, Rupani H, Schwartz LH, Siegel BA, Sorensen AG, Wahl RL, Waterton JC, Wolf W, Zahlmann G, Zimmerman B. Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities. Radiology 259(3):875-884, 2011.
  • Levin VA, Bidaut L, Hou P, Kumar AJ, Wefel JS, Bekele BN, Prabhu S, Loghin M, Gilbert MR, Jackson EF. Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys 79(5):1487-1495, 2011.
  • Lin M, Jackson EF. Applications of Imaging Technology in Radiation Research – Perfusion. Radiation Research 177:387-397, 2012
  • Hamilton JD, Kumar VA, Hayman LA, Prabhu SS, Hou P, Jackson EF, Groneman M, Pagani J, Vabulas M, Kumar AJ. Deformable anatomic templates embed knowledge in brain images: Part 2. validation using functional magnetic resonance imaging of the motor hand. JCAT:J Comput Assist Tomogr 36(2):280-284, 2012.
  • Fu S, Hennessy BT, Ng CS, Ju Z, Coombes K, Wolf JK, Sood AK, Levenback CF, Coleman RL, Karanaugh JJ, Gershenson DM, Markman M, Dice K, Howard A, Li J, Li Y, Stemke-Hale K, Dyer M, Atkinson E, Jackson EF, Kundra V, Kurzrock R, Bast RC, Mills GB. Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer. Gynecologic Oncology 126(1):47-53, 2012.
  • Ng CS, Waterton JC, Kundra V, Brammer D, Ravoori M, Han L, Wei W, Klumpp S, Johnson VE, Jackson EF. Reproducibility and comparison of DCE-MRI and DCE-CT perfusion parameters in a rat tumor model. Technol Cancer Res Treatment 11(3):279-288, 2012.
  • Boonsirikamchai P, Kaur H, Kuban DA, Jackson E, Hou P, Choi H. Use of maximum slope images generated from dynamic contrast-enhanced MRI to detect locally recurrent prostate carcinoma after prostatectomy: a practical approach. AJR 198(3):W228-W236, 2012.
  • Lin JS, Stafford RJ, Hwang K-P, Jackson EF, Hazle JD, Taylor BA. Multi-parametric fat-water separation method for fast chemical-shift imaging guidance of thermal therapy. Med Phys 40(10):103302-1-12, 2013.
  • Versace F, Engelmann JM, Jackson EF, Slapin A, Cortese KM, Bevers TB, Schover LR. Brain responses to erotic and other emotional stimuli in breast cancer survivors with and without distress about low sexual desire: a preliminary fMRI study. Brain Imaging Behav, 7:533-542, 2013.
  • Versace F, Engelmann JM, Robinson JD, Jackson EF, Green CE, Lam CY, Minnix JA, Karam-Hage MA, Brown VL, Wetter DW, Cinciripini PM. Pre-quit fMRI responses to pleasant and cigarette cues predict smoking cessation outcome. Nicotine Tobacco Res, 16(6):697-708, 2014. PMID: 24376278 PMCID: PMC4015090
  • Falchook GS, Wheler JJ, Naing A, Jackson EF, Janku F, Hong D, Ng CS, Tannir NM, Lawhorn KN, Huang M, Angelo LS, Vishwamitra D, Hess K, Howard AN, Parkhurst KL, Amin HM, Kurzrock R. Targeting hypoxia-inducible factor 1-a (HIF-1a) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab. Oncotarget 5(21):10280-92, 2014. PMID: 25373733 PMCID: PMC4279372
  • Obuchowski NA, Reeves AP, Huang HP, Wang XF, Buckler AJ, Kim HJ, Barnhart HX, Jackson EF, Giger ML, Pennello G, Toledano AY, Kalpathy-Cramer J, Apanasovich TV, Kinahan PE, Myers KJ, Goldgof DB, Barboriak DP, Gilles RJ, Schwartz LH, Sullivan AD. Quantitative imaging biomarkers: A review of statistical methods for computer algorithm comparisons. Stat Methods Med Res 24(1):68-106, 2015. epub on 6/11/2014. PMID: 24919829 PMCID: PMC4263694
  • Huang EP, Wang XF, Roy Choudhury K, McShane LM, Gönen M, Ye J, Buckler AJ, Kinahan PE, Reeves AP, Jackson EF, Guimaraes AR, Zahlmann G. Meta-analysis of the technical performance of an imaging procedure: Guidelines and statistical methodology. Stat Methods Med Res 24(1):141-71, 2015. epub on 5/28/2014. PMID: 24872353
  • Kanal E, Froelich J, Barkovich AJ, Borgstede J, Bradley W Jr, Gimbel JR, Gosbee J, Greenberg T, Jackson E, Larson P, Lester J Jr, Sebek E, Shellock FG, Weinreb J, Wilkoff BL, Hernandez D. Standardized MR terminology and reporting of implants and devices as recommended by the American College of Radiology Subcommittee on MR Safety. Radiology 274:866-870, 2015. epub on 10/20/2014. PMID: 25329683
  • Hamilton JD, Lin J, Ison C, Leeds NE, Jackson EF, Fuller GN, Ketonen L, Kumar AJ. Dynamic contrast-enhanced perfusion processing for neuroradiologists: model-dependent analysis may not be necessary for determining recurrent high-grade glioma versus treatment effect. AJNR Am J Neuroradiol, 36(4):686-93, 2015. epub on 12/11/2014. PMID: 25500312
  • Ng CS, Wei W, Bankson JA, Ravoori MK, Han L, Brammer DW, Klumpp S, Waterton JC, Jackson EF. Dependence of DCE-MRI biomarker values on analysis algorithm. PLoS One, 10(7):e0130168. epub on 7/24/2015. PMID: 26208254, PMCID: PMC4514853
  • Bosca RJ, Jackson EF. Creating an anthropomorphic digital MR phantom: An extensible tool for comparing and evaluating quantitative imaging algorithms. Phys Med Biol 61(2):974-982, 2016. PMID: 26738776