Department of Medical Physics
University of Wisconsin School of Medicine and Public Health

R. Jerry Nickles

Credentials: Ph.D.

Position title: Emeritus Professor, Medical Physics

Email: rnickles@wisc.edu

Phone: 608/263-1026

Address:
B1314 WIMR

Education

  • B.S., University of Wisconsin, Madison (Math/Physics)
  • M.S., University of Sao Paulo, Brazil (Nuclear Physics)
  • Ph.D., University of Wisconsin, Madison (Nuclear Physics)

Department Affilations

  • Medical Physics
  • Radiology
  • Physics

Positions

  • 1976-1981, Associate Professor of Radiology, University of Wisconsin, Madison, WI
  • 1977, Visiting Professor, University of Sao Paulo, Brazil
  • 1980, Exchange Visiting Professor, University of Helsinki, Finland
  • 1981‑Present, Professor of Medical Physics and Radiology, University of Wisconsin, Madison
  • 1999, Exchange Visiting Professor, Paul Scherrer Institut, Villigen, Switzerland
  • 2003, Visiting Professor, Addenbrookes Hospital, Cambridge University, Cambridge, UK

Publications

  • Roberts AD, Davidson RJ, Nickles RJ. Production of F-17, O-15 and Other Radioisotopes for PET Using a 3 MV Electrostatic Tandem Accelerator. AIP Conf Proc 415 (1999).
  • Hoachachka PW, Clark CM, Matheson GO, Brown WD, Stone CK, Nickles RJ, Holden JE. Effects on Regional Brain Metabolism of Prolonged :High Altitude Hypoxia: A Study of Six US Marines. Am J Physiol 46, (1999) R314-319.
  • DeJesus OT, Brown WD, Shelton SE, Roberts AD, Nickles RJ, Holden JE. Studies in Rhesus Monkeys Using 6-Fluoro Meta Tyrosine: an Aromatic L-Amino Acid Decarboxylase Tracer. J Lab Radiocompounds 42, (1999) S392-394.
  • Nickles RJ, Jensen M, Paans AMJ, Holm S, Schueller MJ, Vaalburg W. Doppler Broadening Revealing the Chemical Environment Following Oxygen-14 Decay. Radiochimica Acta 88, (2000) 189-192.
  • Brown WD, Taylor MD, Roberts AD, Oakes TR, Schueller MJ, Holden JE, Malischke LM, DeJesus OT, Nickles RJ. FluoroDOPA PET Shows the Non-dopaminergic as well as Dopaminergic Desitinations of Levodopa. Neuroliogy 53,(1999) 1212-18.
  • Brown WD, deJesus OT, Pyzalski RW, Malischke LM, Roberts AD, Shelton SE, Uno H, Houser WD, Nickles RJ, Holden JE. Localization and Trapping of [F-18]-m-tyrosine, an AAAD Tracer for PET. Synapse 34, (1999) 111-123.
  • Nickles RJ. A Positron Floodlight for PET Attenuation Measurements, IEEE Trans Nucl Sci 48 (1), 157-162 (2001).
  • DeGrado TR, Wang S, Holden JE, Nickles RJ, Taylor MD, Stone CK. Synthesis and Preliminary Evaluation of 18F-labeled 4-Thia Palmitate (FTP) as a PET Tracer of Myocardial Fatty Acid Oxidation. Nucl Med and Biol 27, 221-231 (2000).
  • Alves F, Jensen M, Jensen H, Nickles RJ, Holm S. Determination of the excitation function for the 10B(p,n)10C reaction and its implications for the production of [10C]CO2 for use as a steady state PET tracer. Int J Appl Rad Isotopes 54 (4), (2000), 899-903.
  • Brown WD, DeJesus OT, Shelton SE, Uno H, Houser D, Nickles RJ, Roberts AD, Holden JE. Localization of the Trapping of [F-18]-6-fluoro-m-tyrosine, A Tracer of Monoamine Terminals for PET. Synapse 34 (2), (1999), 111-123.
  • DeJesus OT, Solin O, Haaparanta M, Nickles RJ. 6-FluoroDOPA Metabolites in Rat Striatum: Time Course of Extracellular and Intraneuronal Localization. Brain Research 877, 31-36 (2000).
  • Wallhaus TR, Taylor MD, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK.Myocardial Free Fatty Acid and Glucose Use After Carvedilol Treatment in Patinet6s with Congestive Heart Failure. Circ 103, 2442-6 (2001).
  • Taylor MD, Wallhaus TR, DeGrado TR, Russel DC, Stanko P, Nickles RJ, Stone CK. An Evaluation of Myocaridal Fatty Acid and Gluocse Uptake using PET and [F-18] Fuoro-6-Thia Heptadecanoic Acid and [F-18]FDG in patients with Congestive Heart Failure. J Nucl Med 42, 55-62 (2001).
  • Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Using 10CO2 for Single Subject Characterization of the Stimulus Frequency Dependence in Visual Cortex: A Novel Positron Emission Tomography Tracer for Human Brain Mapping. J Cereb Blood Flow Metab 21`: 1003-12 (2001).
  • DeJesus OT. Endres CJ. Shelton SE. Nickles RJ. Holden JE. Noninvasive assessment of aromatic L-Amino acid decarboxylase activity in aging rhesus monkey brain in vivo. Synapse. 39(1):58-63, (2001)
  • Schueller MJ, Mulnix TL, Christian BT, Jensen M, Holm S, Oakes TR, Roberts AD, Dick DW, Martin CC, Nickles RJ.Addressing the Third Gamma Problem in PET. MO5A-26. Nucl Sci Symp (2002).
  • DeJesus OT, Shelton SE, Roberts AD, Nickles RJ, Holden JE. Effect of Tetrabenazine on the Striatal Uptake of Exogenous of L-DOPA In Vivo . Synapse 44: 246-251 (2002).
  • Nickles RJ. The Production of a Broad Palette of PET Tracers. J Lab Cmpd Radiopharm 46, 1-27 (2003).
  • Converse AK, Barnhart TE, Dabbs KA, DeJesus OT, Larson JA, Nickles RJ, Schneider ML, Roberts AD. Simultaneous PET measurement of rCGF and neurochemical function. J Neurosci Meth 132: 199-208 (2004).
  • Barnhart TE, Converse AK, Dabbs KA, Nickles RJ, Buckley K, Jivan S, Ruth TJ, Roberts AD Water-cooled grid support system for high power irradiation with thin target windows J Appl Rad Isotopes 58: 21-26 (2003).
  • Nickles RJ, Barnhart TE, Avila-Rodrigues MA, Converse AK, Sundaresan R, Nye JA, Dick DW, Roberts AD Production of 16N2 for Instrument Calibration. Radiochimica Acta 92:1-4 (2004).
  • Barnhart TE, Converse AK, Dabbs KA, Nickles RJ, Roberts AD. Water Cooled Grid Support System for High Power Irradiation of Thin Target Windows. Appl Radiation and Isotopes 58, 21-26 (2003).
  • Roberts AD, Barnhart TE, DeJesus OT, Larson J, Nickles RJ, Schueller MJ, Shelton SE, Moore C, Schneider ML. Fetal Alcohol Exposure and Pre-Natyal Stress Result in Altered Dopamnine Function in Monkeys. Neurotoxicology and Teratology, 26, (2004) 169-178.
  • Barnhart TE, Converse AK, Nickles RJ, Roberts AD . Production of [F-17] Fluoromethane (t1/2= 65 sec), an improved PET tracer for rCBF measurement. J Appl Rad Isotopes 62, (2005) 525-32.
  • Endres CJ, DeJesus OT, Uno H, Doudet D, Nickles RJ and Holden JE. Time profile of cerebral [18F]6-fluoro-L-DOPA metabolites in primate: Implications for the Kinetics of Therapeutic L-DOPA, Frontiers in Bioscience, 9:505-512, 2004.
  • DeJesus OT, Flores LG, Roberts AD, Dick DW, Bartlett RM, Murali D., R.J.Nickles, Aromatic L-Amino Acid Decarboxylase (AAAD) Activity in Rhesus Macaque Striatum after MAO-B Inhibition by Ro 16-6491, Synapse 56 (1). 54-6, (2005).
  • Dejesus OT, Flores LG, Murali D, Converse AK, Bartlett RM, Barnhart TE, Oakes TR, Nickles RJ (2005) Aromatic L-amino acid decarboxylase turnover in vivo in rhesus macaque striatum: A microPET study. Brain Research 1054:55-60
  • Nye JA, Avila-Rodrigues MA, Nickles RJ. A Grid-Mounted Niobium Body Target for the Production of Reactive [F-18]-Fluoride. Int J Appl Rad Isotopes 64, 536-539, (2006).
  • Nye JA, Avila-Rodriguez MA, Nickles RJ. Production of [I-124]-iodine on an 11 MeV cyclotron. Radiochim Acta 94, 213-216 (2006).
  • Nye JA, Dick DW, Avila-Rodriguez MA, Nickles RJ. Radiohalogen targetry at the University of Wisconsin. Nucl Instr Meth B, 241 (2006) 693-696.
  • Nye JA, Avila-Rodriguez MA, Nickles RJ. A new binary compound for the production of I-124 via the 124Te(p,n)124I reaction. Appl. Radiat. Isot. 65 (4) 407-412 (2007).
  • Selwyn RG, Nickles RJ, Thomadsen BR, DeWerd LA, Micka JA. A new internal pair production branching ratio of Y-90: The development of a non-destructive assay for Y-90 and Sr-90. Appl Rad Isotopes 65 (2007), 318-327.
  • Avila-Rodriguez MA, Nye JA, Nickles RJ. Simultaneous production of high specific activity Cu-64 and Co-61 with 11.4 MeV protons on enriched Ni-64 nuclei. (accepted Appl Rad Isotopes, 2007).
  • Avila-Rodriguez MA, Nye JA, Nickles RJ. Production and separation of non-carrier-added Y-86 from enriched Sr-86 nuclei. (accepted by Appl Rad Isotopes, 2007).
  • Avila-Rodriguez MA, Selwyn RG, Hampel JA, Thomadsen BR, DeJesus OT, Converse AK, Nickles RJ. Positron emitting resin microspheres as surrogates of Y-90 SIR-Spheres: A radiolabeling and stability study. (Accepted by Nucl Med Biol, 2007).

Memberships

  • American Physical Society
  • Society of Nuclear Medicine (SNM)
  • American Chemical Society-Nuclear Chemistry Division