Ivan Rosado-Mendez

Ph.D.

Assistant Professor

rosadomendez@wisc.edu

(608) 261-1875

L1157 WIMR

Biography

Dr. Ivan M. Rosado-Mendez is an assistant professor in the Department of Medical Physics, with a joint appointment in the Department of Radiology. He received his B.S. degree in engineering physics from the Tecnológico de Monterrey, his M.S. degree in medical physics from the National Autonomous University of Mexico (UNAM), and his Ph.D. degree in medical physics from the University of Wisconsin–Madison. After graduating in 2014, he stayed at UW-Madison as a postdoctoral fellow and then as an assistant scientist. From 2017 to 2021, he was an assistant professor at UNAM’s Institute of Physics.

His research is centered on developing quantitative methods for medical imaging. As part of his master’s studies, he investigated the quantitative potential of contrast-enhanced digital mammography, which complements conventional mammography with functional images of tumor vascularization. His work led to the implementation of this technique at the National Institute of Cancerology in Mexico City, where it continues to be used today. As part of his doctoral studies, he developed quantitative ultrasound imaging techniques based on the analysis of coherent and incoherent acoustic scattering to be used as biomarkers for changes in tissue microstructure. As part of a continuing collaboration with the Quantitative Ultrasound Lab (QUL) at UW-Madison, his group at UNAM assessed changes in the viscoelastic properties of the uterine cervix during pregnancy in a Rhesus Macaque model using shear wave elasticity imaging. Also, collaborating with the QUL and the Department of Neurology, he has contributed to demonstrating the potential of quantitative ultrasound to detect structural changes in the thalamus of non-human primate neonates associated with anesthesia-induced apoptosis. For this work, in 2018 he received the New Investigator Award of the American Institute of Ultrasound in Medicine (AIUM). He is also interested in the standardization and clinical translation of quantitative ultrasound, which has led him to co-chair the Pulse-Echo Quantitative Ultrasound biomarker committee of the Quantitative Imaging Biomarker Alliance and be an active member of the American Association of Physicists in Medicine and the AIUM. As faculty at UW-Madison, Dr. Rosado-Mendez will expand his research to include quantitative ultrasound biomarkers of tissue function, with a focus on vascular processes. He is enthusiastic about the immense potential of this bimodal (structural and functional) approach to quantitative ultrasound which, combined with the widespread use of ultrasound imaging, could lead to exciting new venues for personalized medicine.

Education

August 2014 – PhD – Medical Physics (Imaging track), University of Wisconsin-Madison

May 2011 – M.Sc. – Medical Physics (Imaging track), University of Wisconsin-Madison

February 2009 – M.Sc. – Medical Physics, Universidad Nacional Autónoma de México (UNAM)

May 2006 – B. Sc. – Engineering Physics, Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM)

Honors and Awards

  • 2021 – “Centennial Scholar,” School of Medicine and Public Health, University of Wisconsin-Madison
  • 2021 – “Juan Manuel Lozano” Diploma to Abel Torres for excellence in M.Sc. studies and thesis (directed by I. Rosado-Mendez). Instituto de Física, UNAM, Mexico City, MEX
  • 2019 – “Carlos Graef” best student poster award to Laura Castañeda-Martínez, National Physics Congress, Mexican Physics Society, Villahermosa, MEX
  • 2019-2023 – National Science Network (SNI), Level I (renewal), Mexico City, MEX
  • 2018 – New Investigator Award, American Institute of Ultrasound in Medicine, New York, NY
  • 2017-2021 – Honorary Fellow, Department of Medical Physics, University of Wisconsin-Madison, WI
  • 2017 – Performance incentive UNAM (PRIDE), level B, Mexico City, MEX
  • 2017-19 – National Science Network (SNI), Level I, Mexico City, MEX
  • 2012 – Best student talk – XII Mexican Symposium on Medical Physics, Oaxaca, MEX
  • 2010 – “Alfonso Caso” Medal to the most outstanding M.Sc. student in the Graduate Program in Physical Sciences, UNAM, Mexico City, MEX
  • 2009 – “Juan Manuel Lozano” Diploma for excellence in M.Sc. studies and thesis. Instituto de Física, UNAM, Mexico City, MEX
  • 2008 – Travel award from the Southwest Chapter of the American Association of Physicists in Medicine (AAPM) to attend the L Annual Meeting of the AAPM, Houston, TX ($500)
  • 2008 – Best student talk – X Mexican Symposium on Medical Physics. Mexico City, MEX
  • 2007 – Excellence and Best Poster awards – 4th Summer School and Workshop in Nuclear Physics Methods and Accelerators in Biology and Medicine. Czech Technical University, Prague, CZR
  • 2006 – Leadership Diploma, ITESM. Monterrey, MEX
  • 2006 – Excellence Award, Best student of Class 2006, ITESM. Monterrey, MEX
  • 2005 – Summer Research award, Mexican Academy of Sciences. Mexico City, MEX ($250)

Professional Affiliations

  • 2018 – Present: Medical Physics for World Benefit
  • 2015 – 2017:  CONACYT Medical Physics Network (Scientist member)
  • 2011 – 2018: IEEE, Ultrasonics, Ferroelectrics, and Frequency Control Society
  • 2011 – Present: American Institute of Ultrasound in Medicine (AIUM)
  • 2008 – Present: American Association of Physicists in Medicine (AAPM)
  • 2007 – Present: Medical Physics Division of the Mexican Physics Society

Leadership

  • 2021: Scientific session organizer at the 2021 AAPM Annual Meeting (virtual). Session title: Frontiers in Ultrasound Imaging, July 26
  • 2021: Moderator of the scientific session “Frontiers in Ultrasound Imaging,” Annual Meeting of the American Association of Physicists in Medicine, July 28, 2021.
  • 2021: Moderator of three scientific sessions, Ultrasonic Imaging and Tissue Characterization Symposium, June 2, 2021.
  • 2021: Moderator of the Session “Liver Fat Quantification with Quantitative Ultrasound” at the Annual Convention of the AIUM, April 11, 2021 (virtual)
  • 2020 – Present: Member of the AAPM Imaging Metrology and Standards Subcommittee
  • 2020 – Present: Member of the AAPM Task Group TG353 – Pulsed Doppler and Color Flow Ultrasound System Performance Assessment using Flow Phantoms
  • 2020: Scientific session organizer at the 2020 AAPM/COMP Annual Meeting (virtual). Session title: Quantitative ultrasound imaging: from the benchtop to a clinical protocol, July 12-16
  • 2020: President of the scientific committee and chief editor of the proceedings of the XVI Mexican Symposium on Medical Physics (virtual), October 26-30 https://aip.scitation.org/doi/10.1063/12.0004192
  • 2020 – Present: Co-chair (academia), Pulse-Echo Quantitative Ultrasound Biomarker Committee, AIUM/Quantitative Imaging Biomarker Alliance (QIBA), Radiological Society of North America
  • 2019: Faculty, AAPM Symposium, International Conference on Medical Physics, September 8-11, Santiago, CHL
  • 2019: Co-organizer of the workshop on tissue-equivalent materials, Instituto de Física, UNAM, November 6
  • 2019: Session moderator at the AAPM annual meeting, July 14-18, San Antonio, TX.
  • 2019 – Present: Member of the AAPM ultrasound subcommittee

Publications

  1. Torres-Añorve, M. L. Palmeri, H. Feltovich, T. J. Hall, I. Rosado-Mendez, “Shear wave dispersion as a potential biomarker for cervical remodeling during pregnancy: evidence from a non-human primate model,” Frontiers in Physics, 8, 606664, 2021 DOI: 10.3389/fphy.2020.606664
  2. Jafarpisheh, T. J. Hall, H. Rivaz, I. M. Rosado-Mendez, “Analytic global regularized backscatter quantitative ultrasound,” IEEE Trans. Ultrason. Ferroelect. Freq. Contrl., in press, 2020 DOI: 10.1109/TUFFC.2020.3042942
  3. Rosado-Mendez, A. Smargiassi, R. Inchingolo, Gino Soldati, M. Muller, L. Demi, “Commentary – Lung Ultrasound for COVID-19 patient management: Please report your settings and MI,” Journal of Ultrasound in Medicine, vol. 40, pp. 187-189, 2020 DOI: 10.1002/jum.15389
  4. Castañeda-Martinez, K. Noguchi, J. A. Zagzebski, C. Ikonomidou, T. J. Hall, I. Rosado-Mendez, “Optimization of ultrasound backscatter spectroscopy to assess neurotoxic effects of anesthesia in the newborn non-human primate brain,” Ultrasound in Medicine and Biology, vol. 46, no. 8, pp. 2044-2056, 2020 DOI: 10.1016/j.ultrasmedbio.2020.04.004
  5. Carlson, H. Feltovich, I. M. Rosado-Mendez, L. Mao, T. Hall, “Quantitative assessment of cervical softening during pregnancy with shear wave elasticity imaging: an in vivo longitudinal study,” Journal of the Royal Society Interface, vol. 9, no. 5, pp. 20190030, 2019 DOI: 10.1098/rsfs.2019.0030
  6. T. Tran, K. Jerzak, F. Lu, J. Klein, S. Tabbarah, A. Lagree, T. Wu, I. Rosado-Mendez, E. Law, K. Saednia, A. Sadeghi-Naini, “Personalized breast cancer treatments using artificial intelligence in Radiomics and Pathomics,” Journal of Medical Imaging and Radiation Sciences, vol. 50, no. 4 (2), pp. S32-S41, 2019 DOI: 10.1016/j.jmir.2019.07.010
  7. Gerges-Nasief, I. M. Rosado-Mendez, J. A. Zagzebski, T. J. Hall, “A quantitative ultrasound-based multi-parameter classifier for breast masses,” Ultrasound in Medicine and Biology, vol. 45, no. 7, pp. 1603-1616, 2019 DOI: 10.1016/j.ultrasmedbio.2019.02.025
  8. Guerrero, H. Feltovich, I. Rosado-Mendez, A. P. Santoso, L. Carlson, R. Zea, T. J. Hall, “Quantitative ultrasound parameters based on the backscattered echo power signal as biomarkers of cervical remodeling in the pregnant Rhesus macaque: a longitudinal study,” Ultrasound in Medicine and Biology, vol. 46, no. 6, pp. 1466-1474, 2019 DOI: 10.1016/j.ultrasmedbio.2018.12.004
  9. M. Rosado-Mendez, K. Noguchi, L. Castañeda-Martinez, G. Kirvassilis, H. Wang, F. Manzella, B. S. Swiney, K. Masuoka, S. Capuano III, K. G. Brunner, K. Crosno, Q. W. Guerrero, H. Whitson, A. Brambrink, H. S. Simmons, A. F. Mejia, J. A. Zagzebski, T. J. Hall, C. Ikonomidou, “Quantitative ultrasound detects apoptotic death induced by anesthesia in the neonatal primate brain,” Neurobiology of Disease, vol. 127, pp. 554-562, 2019 DOI: 10.1016/j.nbd.2019.03.032
  10. W. Guerrero, H. Feltovich, I. M. Rosado-Mendez, L. C. Carlson, T. J. Hall, “Quantitative ultrasound biomarkers based on backscattered acoustic power: potential for quantifying remodeling of the human cervix during pregnancy” Ultrasound in Medicine and Biology, vol. 45, no. 2, pp. 429-439, 2019 DOI: 10.1016/j.ultrasmedbio.2018.08.019
  11. Vajihi, I. M. Rosado-Mendez, T. J. Hall, H. Rivaz, “Low variance estimation of backscatter quantitative ultrasound parameters using dynamic programming,” IEEE Trans. Ultrason. Ferroelect. Freq. Contrl., vol. 65, no. 11, pp. 2042-2053, 2018 DOI: 10.1109/TUFFC.2018.2869810
  12. W. Guerrero, L. Fan, S. Brunke, A. Milkowski, I. M. Rosado-Mendez, T. J. Hall, “Power spectrum consistency among systems and transducers,” Ultrasound in Medicine and Biology, vol. 44, no. 11, pp. 2358-2370, 2018 DOI: 10.1016/j.ultrasmedbio.2018.05.013
  13. M. Rosado-Mendez, L. C. Carlson, K. M. Woo, A. P. Santoso, Q. W. Guerrero, M. L. Palmeri, H. Feltovich, T. J. Hall, “Quantitative assessment of cervical softening during pregnancy in the Rhesus macaque with shear wave elasticity imaging,” Physics in Medicine and Biology, vol. 63, no. 8, pp. 085016, 2018 DOI: 10.1088/1361-6560/aab532
  14. W. Guerrero, H. Feltovich, I. M. Rosado-Mendez, L. C. Carlson, G. Li, T. Hall, “Anisotropy and spatial heterogeneity in quantitative ultrasound parameters: Relevance to study of the human cervix,” Ultrasound in Medicine and Biology, vol. 44, no. 7, pp. 1493-1503, 2018 DOI: 10.1016/j.ultrasmedbio.2018.02.008
  15. C. Carlson, T. J. Hall, I. M. Rosado-Mendez, M. L. Palmeri, H. Feltovich, “Detection of changes in cervical softness using shear wave speed in early vs. late pregnancy: an in vivo cross-sectional study” Ultrasound in Medicine and Biology, vol. 44, no. 3, pp. 515-521, 2018 DOI: 10.1016/j.ultrasmedbio.2017.10.017
  16. Guerrero, I. M. Rosado-Mendez, L. C. Drehfal, H. Feltovich, T. J. Hall, “Quantifying backscatter anisotropy using the reference phantom method,” IEEE Trans. Ultrason. Ferroelect. Freq. Control, vol. 64, no. 7, pp. 1063-1077, 2017 DOI: 10.1109/TUFFC.2017.2698832
  17. M. Rosado-Mendez, M. L. Palmeri, L. C. Drehfal, Q. W. Guerrero, H. Simmons, H. Feltovich, T. J. Hall, “Assessment of structural heterogeneity and viscosity in the cervix using shear wave elasticity imaging: initial results from a Rhesus macaque model,” Ultrasound in Medicine and Biology, vol. 43, no. 4, pp. 790-808, 2017 DOI: 10.1016/j.ultrasmedbio.2016.12.006
  18. E. Brandan, J. Cruz-Bastida, I. M. Rosado-Mendez, Y. Villaseñor-Navarro, H. Pérez-Ponce, H. Galván, F. Trujillo-Zamudio, P. Sánchez-Suárez, L. Benítez-Bribiesca, “Clinical study of contrast-enhanced digital mammography and the evaluation of blood and lymphatic microvessels,” British J. of Radiology, vol. 89, no. 1065, pp. 20160232, 2016 DOI: 10.1259/bjr.20160232
  19. Huang, L. C. Drehfal, I. M. Rosado-Mendez, Q. W. Guerrero, M. L. Palmeri, H. A. Simmons, H. Feltovich, T. J. Hall., “Estimation of shear wave speed in the Rhesus Macaque uterine cervix,” IEEE Trans. Ultrason. Ferroelect. Freq. Contrl., vol. 63, no. 9, pp. 1243-1252, 2016 DOI: 10.1109/TUFFC.2016.2524259
  20. M. Rosado-Mendez, L. C. Drehfal, J. A. Zagzebski, T. J. Hall, “Analysis of coherent and diffuse scattering using a reference phantom,” IEEE Trans. Ultrason. Ferroelect. Freq. Contrl., vol. 63, no. 9, pp. 1306-1320, 2016 DOI: 10.1109/TUFFC.2016.2547341
  21. Gerges-Nasief, I. Rosado-Mendez, J. A. Zagzebski, T. J. Hall, “Acoustic properties of breast fat,” Journal of Ultrasound in Medicine, vol. 34, no. 11, pp. 2007-2016, 2015 DOI: 10.7863/ultra.14.07039
  22. A. Wirtzfeld, G. Ghoshal, I. M. Rosado-Mendez, K. Nam, Y. Park, A. D. Pawlicki, R. J. Miller, D. G. Simpson, J. A. Zagzebski, M. L. Oelze, T. J. Hall, W. D. O’Brien Jr, “Quantitative ultrasound comparison of MAT and 4T1 mammary tumors in mice and rats across multiple imaging systems,” Journal of Ultrasound in Medicine, vol. 34, no. 8, pp. 1373-1383, 2015 DOI: 10.7863/ultra.34.8.1373
  23. Rosado-Mendez, K. Nam, T. J. Hall, J. A. Zagzebski, “Task-oriented comparison of power spectral density estimation methods for quantifying acoustic attenuation in diagnostic ultrasound using a reference phantom method,” Ultrasonic Imaging, vol. 35, no. 3, pp. 214-234, 2013 DOI: 10.1177/0161734613495524
  24. Nam, I. Rosado-Mendez, L. A. Wirtzfeld, V. Kumar, E. L. Madsen, G. Ghoshal, A. D. Pawlicki, M. L. Oelze, R. J. Lavarello, T. A. Bigelow, J. A. Zagzebski, W. D. O’Brien Jr, T. J. Hall, “Cross-imaging system comparison of backscatter coefficient estimates from a tissue-mimicking material,” Journal of the Acoustical Society of America, vol. 132, no. 3, pp. 1319-1324, 2012 DOI: 10.1121/1.4742725
  25. Nam, I. Rosado-Mendez, L. A. Wirtzfeld, G. Ghoshal, A. Pawlicki, E. L. Madsen, R. J. Lavarello, M. L. Oelze, J. A. Zagzebski, W. D. O’Brien Jr, T. J. Hall, “Comparison of ultrasound attenuation and backscatter estimates in layered tissue-mimicking phantoms among three clinical scanners,” Ultrasonic Imaging, vol. 34, no. 4, pp. 209-221, 2012 DOI: 10.1177/0161734612464451
  26. Nam, I. M. Rosado-Mendez, N. C. Rubert, E. L. Madsen, J. A. Zagzebski, T. J. Hall, “Ultrasound attenuation measurements using a reference phantom with sound speed mismatch,” Ultrasonic Imaging, vol. 33, no. 4, pp. 251-263, 2011 DOI: 10.1177/016173461103300404
  27. Nam, I. Rosado-Mendez, L. A. Wirtzfeld, A. D. Pawlicki, V. Kumar, E. L. Madsen, G. Ghoshal, R. J. Lavarello, M. L. Oelze, T. A. Bigelow, J. A. Zagzebski, W. D. O’Brien Jr, “Ultrasonic attenuation and backscatter coefficient estimates of rodent-tumor mimicking structures: comparison of results among clinical scanners”, Ultrasonic Imaging, vol. 33, no. 4, pp. 233-250, 2011 DOI: 10.1177/016173461103300403
  28. A. Palma, I. Rosado-Mendez, and M. E. Brandan, “Phantom study to evaluate contrast-medium-enhanced digital subtraction mammography with standard spectra,” Medical Physics, vol. 37, no. 2, pp. 577-589, 2010 DOI: 10.1118/1.3276733
  29. Rosado-Mendez, B. A. Palma, and M. E. Brandan, “Analytical optimization of digital subtraction mammography with contrast medium using a commercial unit,” Medical Physics, vol. 35, no. 12, pp. 5544-5557, 2008 DOI: 10.1118/1.3003063