Skip to Content

James Holden, Ph.D.

James E. Holden Ph.D.

Emeritus Professor, Medical Physics

Department Affiliations

Medical Physics



B.S., Physics, Providence College (RI)

Ph.D., Nuclear Physics, University of Pennsylvania

Awards and Honors

Picker Scholar, James A Picker Foundation


  • Society of Cerebral Blood Flow and Metabolism

  • Society of Nuclear Medicine

  • Society of Neuroscience

  • Fellow, American Heart Association


  • Endres CJ. DeJesus OT. Uno H. Doudet DJ. Nickles JR. Holden JE. Time profile of cerebral [18F]6-fluoro-L-DOPA metabolites in nonhuman primate: implications for the kinetics of therapeutic L-DOPA. Frontiers in Bioscience. 9:505-12, 2004 Jan 1.
  • Sossi V. de la Fuente-Fernandez R. Holden JE. Schulzer M. Ruth TJ. Stoessl J. Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms. Journal of Cerebral Blood Flow & Metabolism. 24(8):869-76, 2004 Aug.
  • Doudet DJ. Holden JE. Raclopride studies of dopamine release: dependence on presynaptic integrity. Biological Psychiatry. 54(11):1193-9, 2003 Dec 1.
  • Doudet DJ. Holden JE. Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: effect of methamphetamine. Journal of Cerebral Blood Flow & Metabolism. 23(12):1489-94, 2003 Dec.
  • DeJesus OT. Shelton SE. Roberts AD. Nickles RJ. Holden JE. Effect of tetrabenazine on the striatal uptake of exogenous L-DOPA in vivo: a PET study in young and aged rhesus monkeys. Synapse. 44(4):246-51, 2002 Jun 15.
  • Lee CS. Samii A. Sossi V. Ruth TJ. Schulzer M. Holden JE. Wudel J. Pal PK. de la Fuente-Fernandez R. Calne DB. Stoessl AJ. In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease. Annals of Neurology. 47(4):493-503, 2000 Apr.
  • Sossi V. Holden JE. Chan G. Krzywinski M. Stoessl AJ. Ruth TJ. Analysis of four dopaminergic tracers kinetics using two different tissue input function methods. Journal of Cerebral Blood Flow & Metabolism. 20(4):653-60, 2000 Apr.
  • Chan GL. Holden JE. Stoessl AJ. Samii A. Doudet DJ. Dobko T. Morrison KS. Adam M. Schulzer M. Calne DB. Ruth TJ. Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects. [Journal Article] Journal of Nuclear Medicine. 40(2):283-9, 1999 Feb.

Copyright © 2011 The Board of Regents of the University of Wisconsin System