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Ke Li, Ph.D.

Ke Li, Ph.D.

Assistant Professor, Medical Physics and Radiology

Department Affiliations

Medical Physics

Radiology

Education

B.S., Nanjing University (China), Physics 2006

M.S., The Ohio State University, Physics, 2009

Ph.D., University of Wisconsin-Madison, Medical Physics, 2013

Research Interests

Diagnostic CT imaging

X-ray phase contrast imaging

CT perfusion imaging

Task-based image quality assessment for iterative reconstruction algorithms

Instrumentation and optimization of novel x-ray CT imaging systems

Positions

  • 2017-present, Assistant Professor, Departments of Medical Physics and Department of Radiology, University of Wisconsin-School of Medicine and Public Health, Madison, WI
  • 2014-2016, Assistant Professor (CHS), Departments of Medical Physics and Department of Radiology, University of Wisconsin-School of Medicine and Public Health, Madison, WI
  • 2013-2014, Assistant Scientist, Department of Medical Physics, University of Wisconsin-School of Medicine and Public Health, Madison, WI

Awards and Honors

  • AAPM Research Seed Funding Initiative (2015)
  • BEST IN PHYSICS Award, AAPM Annual Meeting (2014)
  • Editor's Picks, Medical Physics Journal (2014)
  • BEST IN PHYSICS Award, AAPM Annual Meeting (2013)
  • Runner-up of the Best Student Paper Award, SPIE Medical Imaging (2013)
  • Honorable Mention Poster Award (co-author), SPIE Medical Imaging (2011)

Memberships

  • American Association of Physicists in Medicine

Publications

Peer Reviewed

  • X. Ji, R. Zhang, GH. Chen, K. Li, "Impact of anti-charge sharing on the zero-frequency detective quantum efficiency of CdTe-based photon counting detector system: cascaded systems analysis and experimental validation", Physics in Medicine & Biology, Vol. 63, 095003 (2018) [DOI]
  • D. Gomez‐Cardona, JW. Hayes, R. Zhang, K. Li, J. P. Cruz‐Bastida, G.-H. Chen, " Low‐dose cone‐beam CT via raw counts domain low‐signal correction schemes: Performance assessment and task‐based parameter optimization (Part II. Task‐based parameter optimization)", Medical physics, Vol. 45, pp 1957-1969 (2018) [DOI]
  • J. W. Hayes, D. Gomez‐Cardona, R. Zhang, K. Li, J. P. Cruz‐Bastida, G.-H. Chen, "Low‐dose cone‐beam CT via raw counts domain low‐signal correction schemes: Performance assessment and task‐based parameter optimization (Part I: Assessment of spatial resolution and noise performance)", Medical physics, Vol. 45, pp 1942-1956 (2018) [DOI]
  • Y. Li, J. W Garrett, K. Li, Y. Wu, K. Johnson, S. Schafer, C. Strother and G.-H. Chen, Time-resolved C-arm cone beam CT angiography (TR-CBCTA) imaging from a single short-scan C-arm cone beam CT acquisition with intra-arterial contrast injection, Physics in Medicine & Biology, Vol. 63, 075001 (2018)
  • X. Ji, Y. Ge, R. Zhang, K. Li, G.-H. Chen, "Studies of signal estimation bias in grating‐based x‐ray multicontrast imaging", Medical Physics, Vol. 44, pp 2453-2465 (2017) [DOI]
  • Y. Ge, X. Ji, R. Zhang, K. Li, G.-H. Chen, "K-edge energy-based calibration method for photon counting detectors ", Physics in Medicine & Biology, Vol. 63, pp 015022 (2017) [DOI]
  • J. P. Cruz-Bastida, D. Gomez-Cardona, J. Garrett, T. Szczykutowicz, G.-H. Chen, K. Li, "Modified ideal observer model (MIOM) for high-contrast and high-spatial resolution CT imaging tasks", Medical Physics Vol. 44, pp 4496-4505, (2017) [DOI]
  • Y. Chen, A. Budde, K. Li, Y. Li, J. Hsieh, G.-H. Chen, "A platform-independent method to reduce CT truncation artifacts using discriminative dictionary representations", Medical Physics Vol. 44, pp. 121–131, (2017) [DOI]
  • B. D. Pooler, M. G. Lubner, D. H. Kim, O. T. Chen, K. Li, G.-H. Chen, P. J. Pickhardt, "Prospective Evaluation of Reduced Dose Computed Tomography for the Detection of Low-Contrast Liver Lesions: Direct Comparison with Concurrent Standard Dose Imaging", European Radiology, (2016) [DOI]
  • D. Gomez-Cardona, J. P. Cruz-Bastida, K. Li, A. Budde, J. Hsieh and G.-H. Chen, "Impact of bowtie filter and object position on the two-dimensional noise power spectrum of a clinical MDCT system", Medical Physics, Vol. 43, pp. 4495-4506, (2016) [DOI]
  • Y. Ge, R. Zhang, K. Li, and G.-H. Chen, "Improving radiation dose efficiency of X-ray differential phase contrast imaging using an energy-resolving grating interferometer and a novel rank constraint", Optics Express, Vol. 24 (12), pp. 12955-12968, (2016) [DOI]
  • J. P. Cruz-Bastida, D. Gomez-Cardona, K. Li, H. Sun, J. Hsieh, T. P. Szczykutowicz, and G.-H. Chen, "Hi-Res scan mode in clinical MDCT systems: Experimental assessment of spatial resolution performance", Medical Physics, Vol. 43, pp. 2399, (2016) [DOI]
  • D. Gomez-Cardona, K. Li, J. Hsieh, M. G. Lubner, P. J. Pickhardt and G.-H. Chen, "Can conclusions drawn from phantom-based image noise assessments be generalized to in vivo studies for the nonlinear model-based iterative reconstruction method?" Medical Physics, Vol. 43, pp. 687 (2016) [DOI]
  • P. Bannas, Y. Li, U. Motosugi, K. Li, M. G. Lubne, G.-H. Chen, P. J. Pickhardt, "Prior Image Constrained Compressed Sensing Metal Artifact Reduction (PICCS-MAR): 2D and 3D Image Quality Improvement with Hip Prostheses at CT Colonograph", European Radiology, (2015) [DOI]
  • D. Gomez-Cardona, S. K. Nagle, K. Li, T. E. Robinson, G.-H. Chen, "Influence of radiation dose and reconstruction algorithm in MDCT assessment of airway wall thickness: A phantom study", Medical Physics, Vol. 42, pp. 5919-5927, (2015) [DOI]
  • J. Garrett, Y. Ge, K. Li, G.-H. Chen, "Correction of data truncation artifacts in differential phase contrast (DPC) tomosynthesis imaging", Physics in Medicine and Biology, Vol. 60, pp.7713 (2015) [DOI]
  • K. Li, D. Gomez-Cardona, J. Hsieh, M. G. Lubner, P. J. Pickhardt and G.-H. Chen, "Statistical model based iterative reconstruction in clinical CT systems. Part III. Task-based kV/mAs optimization for radiation dose reduction", Medical Physics, Vol. 42, pp. 5209 (2015) [DOI]
  • M.G. Lubner, B.D. Pooler, D.R. Kitchin, J. Tang, K. Li, D.H. Kim, A.M. Del Rio , G.-H. Chen and P.J. Pickhardt, "Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging", European Radiology, Vol. 25, pp. 2089-2102 (2015) [DOI]
  • J. Garrett, Y. Ge, K. Li and G.-H. Chen, "Anatomical background noise power spectrum in differential phase contrast and dark field contrast mammograms," Medical Physics, Vol. 41, pp. 120701 (2014) [DOI]
  • K. Li, J. Garrett, Y. Ge, and G.-H. Chen, "Statistical model based iterative reconstruction (MBIR) in clinical CT systems. Part II. Experimental assessment of spatial resolution performance," Medical Physics, Vol. 41 (7), pp. 071911 (2014) [DOI]
  • Y. Ge, K. Li, J. Garrett, and G.-H. Chen, "Grating based x-ray differential phase contrast imaging without mechanical phase stepping," Optics Express, Vol. 22 (12), pp. 14246-14252 (2014) [DOI]
  • K. Li, J. Tang, and G.-H. Chen, "Statistical model based iterative reconstruction (MBIR) in clinical CT systems: Experimental assessment of noise performance," Med. Phys., 41, 041906 (2014) [PubMed]
  • K. Li, Y. Ge, J. Garrett, N. Bevins, J. Zambelli, and G.-H. Chen, "Grating-based phase contrast tomosynthesis imaging: Proof-of-concept experimental studies," Med. Phys., 41, 011903 (2014) editor's picks [PubMed]
  • K. Li, J. Garrett, and G.-H. Chen, "Correlation between human observer performance and model observer performance in differential phase contrast CT," Med. Phys., 40, 111905 (2013) [PubMed]
  • K. Li, J. Zambelli, N. Bevins, Y. Ge, and G.-H. Chen, "Spatial resolution characterization of differential phase contrast CT systems via modulation transfer function (MTF) measurements," Phys. Med. Biol., 58, 4119-4135 (2013) [PubMed]
  • K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "Fundamental relationship between the noise properties of grating-based differential phase contrast CT and absorption CT: Theoretical framework using a cascaded system model and experimental validation," Med. Phys., 40, 021908 (2013) [PubMed]
  • N. Bevins, J. Zambelli, K. Li, Z. Qi, and G.-H. Chen, "Multi-contrast x-ray computed tomography imaging using Talbot-Lau interferometry without phase stepping," Med. Phys., 39, 424-428 (2012) [PubMed]
  • G.-H. Chen, J. Zambelli, K. Li, N. Bevins ,and Z. Qi, "Scaling law for noise variance and spatial resolution in differential phase contrast computed tomography," Med. Phys., 38, 584-588 (2011) [PubMed]
  • G.-H. Chen, J. Zambelli, N. Bevins ,Z. Qi, and K. Li, "X-ray phase sensitive imaging methods: Basic physical principles and potential medical applications," Curr. Med. Imaging Rev., 6, 90-99 (2010) [PubMed]

Conference Proceedings

  • K. Li, G.-H. Chen, "Noise characteristics of CT perfusion imaging: How does noise propagate from source images to final perfusion maps?," Proc. SPIE, 9783, 978310 (2016), [DOI]
  • Y. Ge, R. Zhang, K. Li, G.-H. Chen, "X-ray differential phase contrast imaging using a grating interferometer and a single photon counting detector," Proc. SPIE, 9783, 97830M (2016), [DOI]
  • R. Zhang, B. Qin, Y. Ge, B. Whiting, K. Li, F. Villanueva, G.-H. Chen, "Potential use of micorobubbles (MBs) as contrast material in x-ray dark field (DF) imaging: How does the DF signal change with the characteristic parameters of the MBs?," Proc. SPIE, 9783, 97830N (2016), [DOI]
  • Y. Li, K. Niu, K. Li, S. Schafer, K. Royalty, C. Strother, G.-H. Chen, "C-arm cone beam CT perfusion imaging using the SMART-RECON algorithm to improve temporal sampling density and temporal resolution," Proc. SPIE, 9783, 97830U (2016), [DOI]
  • D. Gomez-Cardona, J. P. Cruz-Bastida, K. Li, A. Budde, J. Hsieh, G-H. Chen, "Noise power spectrum studies of CT systems with off-centered image object and bowtie filter," Proc. SPIE. 9783, 97833A (2016), [DOI]
  • Y. Chen, K. Li, Y. Li, J. Hsieh, G-H Chen, "Reduction of truncation artifacts in CT images via a discriminative dictionary representation method," Proc. SPIE. 9783, 97831D. (2016), [DOI]
  • K. Li, D. Gomez-Cardona, M. G. Lubner, P. J. Pickhardt, and G.-H. Chen, "Imaging task-based optimal kV and mA selection for CT radiation dose reduction: from filtered backprojection (FBP) to statistical model based iterative reconstruction (MBIR)," Proc. SPIE, 9412, 94121M (2015) [DOI]
  • Y. Ge, W. Zhao, J. Garrett, K. Li, and G.-H. Chen, "Absorption imaging performance in a future Talbot-Lau interferometer based breast imaging system," Proc. SPIE, 9412, 94123X (2015) [DOI]
  • J. Garrett, Y. Ge, K. Li, and G.-H. Chen, "Anatomical background noise power spectrum in differential phase contrast breast images," Proc. SPIE, 9412, 94121J (2015) [DOI]
  • D. Gomez-Cardona, K. Li, M. G. Lubner, P. J. Pickhardt, and G.-H. Chen, "Noise performance studies of model-based iterative reconstruction (MBIR) as a function of kV, mA and exposure level: Impact on radiation dose reduction and image quality," Proc. SPIE, 9412, 941238 (2015) [DOI]
  • Y. Ge, J. Garrett, K. Li, and G.-H. Chen, "New signal extraction method in x-ray differential phase contrast imaging with a tilted collinear analyzer grating," Proc. SPIE, 9412, 94120H (2015) [DOI]
  • J. Garrett, Y. Ge, K. Li, and G.-H. Chen, " Methods to mitigate data truncation artifacts in multi-contrast tomosynthesis image reconstructions," Proc. SPIE, 9412, 941225 (2015) [DOI]
  • K. Li, J. Tang, and G.-H. Chen, "CT Protocol Optimization at the Dawn of Iterative Reconstruction: Challenges and Solutions," The Third International Conference on Image Formation in X-Ray Computed Tomography (2014) [link]
  • Y. Ge, K. Li, and G.-H. Chen, "Cramer-Rao lower bound in differential phase contrast imaging and its application in the optimization of data acquisition system" Proc. SPIE, 9033 (2014) [DOI]
  • Y. Ge, K. Li, and G.-H. Chen, "Statistical signal estimation methods in x-ray differential phase contrast imaging" Proc. SPIE, 9033 (2014) [DOI]
  • Y. Ge, K. Li, and G.-H. Chen, "Fast data acquisitions in x-ray differential phase contrast imaging using a new grating design" Proc. SPIE, 9033 (2014) [DOI]
  • K. Li, J. Tang, and G.-H. Chen, "Experimental characterization of the noise performance of statistical model based iterative reconstruction (MBIR) in a clinical CT system" Proc. SPIE, 9033 (2014) [DOI]
  • K. Li, J. Zambelli, N. Bevins, and G.-H. Chen, "Experimental measurement of the modulation transfer function of differential phase contrast CT Systems," Proc. SPIE, 8668 (2013) [DOI]
  • K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "Model observer and human observer performance studies in differential phase contrast CT," Proc. SPIE, 8668 (2013) [DOI]
  • K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "How to determine detection performance of a DPC-CT system from a conventional cone beam CT system?" Proc. SPIE, 8668 (2013) [DOI]
  • N. Bevins, K. Li, J. Zambelli, and G.-H. Chen, "Type II beam hardening artifacts in phase contrast imaging," Proc. SPIE, 8668 (2013) [DOI]
  • K. Niu, K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "A statistical image reconstruction method to reduce small angle scattering induced streaking artifacts in differential phase contrast CT," Proc. SPIE, 8668 (2013) [DOI]
  • K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "Feasibility of differential phase contrast CT for whole body imaging," AIP Conference Proceedings, 1466, 175-180 (2012) [DOI]
  • N. Bevins, J. Zambelli, K. Li, and G.-H. Chen, "Comparison of phase contrast signal extraction techniques," AIP Conference Proceedings, 1466, 169-174 (2012) [DOI]
  • N. Bevins, J. Zambelli, K. Li, Z. Qi, and G.-H. Chen, "Experimental study of the impact of small-angle scatterers on the x-ray dark field imaging contrast mechanism," Proc. SPIE, 8313, 83135L (2012) [DOI]
  • K. Li, N. Bevins, J. Zambelli, Z. Qi, and G.-H. Chen, "Detection performance study for cone-beam differential phase contrast CT," Proc. SPIE, 8313, 83131L (2012) [DOI]
  • K. Li, N. Bevins, J. Zambelli, Z. Qi, and G.-H. Chen, "A new image reconstruction method to improve noise properties in x-ray differential phase contrast computed tomography," Proc. SPIE, 8313, 83131V (2012) [DOI]
  • K. Li, N. Bevins, J. Zambelli, and G.-H. Chen, "Differential phase contrast tomosynthesis imaging," Proc. SPIE, 8313, 83131Z (2012) [DOI]
  • J. Zambelli, K. Li, N. Bevins, and G.-H. Chen, "Optimization of grating designs for x-ray differential phase contrast imaging," Proc. SPIE, 8313, 83135B (2012) [DOI]
  • N. Bevins, J. Zambelli, K. Li, Z. Qi, and G.-H. Chen, "Beam hardening in x-ray differential phase contrast computed tomography," Proc. SPIE, 7961, 79611H (2011) [DOI]
  • Z. Qi, P. Thériault-Lauzier, N. Bevins, J. Zambelli, K. Li, and G.-H. Chen, "Helical x-ray differential phase contrast computed tomography," Proc. SPIE, 7961, 79611Q (2011) [DOI]
  • J. Zambelli, K. Li, N. Bevins, Z. Qi, and G.-H. Chen, "Noise characteristics of x-ray differential phase contrast CT," Proc. SPIE, 7961, 79613N (2011) [DOI]


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