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Tomy Vargese Ph.D.

Tomy Varghese Ph.D.

Professor, Medical Physics

Department Affiliations

Medical Physics

Biomedical Engineering

Electrical and Computer Engineering


B.E., (1988) Instrumentation Techology University of Mysore, SJCE, Mysore, India

M.S., (1992) Electrical Engineering, University of Kentucky, Lexington, KY

Ph.D., (1995) Electrical Engineering, University of Kentucky, Lexington, KY

Research Interest

  • Elastography

  • In-vivo strain imaging

  • Signal & Image Processing Applications in Medical Imaging

  • Ultrasound Tissue Characterization

My primary research interests are in signal and image processing applications in medical imaging for the early detection of cancer. Early detection of cancers can significantly improve patient survival rate and lead to effective treatment. The aim of this research project is to develop signal-processing tools for extracting relevant tissue microstructure information embedded in the spectra of RF broadband ultrasonic echoes. The ultimate goal is to provide fast, reliable and well-understood signal processing techniques for the early detection of malignant tissue using ultrasound. A unique aspect of this research is its focus on characterizing Fourier phase and magnitude of RF ultrasonic echoes with spectral redundancy characterized by the spectral autocorrelation function (also called the Generalized Spectrum). Disruptions in the normal structure of liver and breast tissue due to invading cancers, are detected by examining the changes in the quasi-periodic nature of the liver tissue and the presence of specular scatterers (calcifications in malignant tissue) in breast tissue using this innovative approach. This method is more accurate than the traditional techniques used to estimate the scatterer spacing.

My current research deals with the development of Elastography. Elastography is rapidly developing into a new ultrasonic imaging modality, capable of producing images of internal strain or tissue elasticity. Elastography is a method for imaging the elastic properties of compliant tissues, producing gray scale strain images referred to as elastograms. You can think of Elastography as a "high tech" form of palpation. Elastography has been used for imaging and characterizing tumors in the breast, prostate, kidney, liver, muscle and other tissues. Ultrasonic visualization is widely used in practically all-medical specialties. The proposed technique could therefore have a large impact on medical practice in the United States. Elastograms have also been obtained using MRI, and Optical Coherence Tomographic (OCT) methods.


  • 07/1995-07/2000, Post-Doctoral Fellow, Radiology, University of Texas Medical School, Houston

  • 08/2000 - 04/2006, Assistant Professor, University of Wisconsin, Madison

  • 04/2006 - 03/2011, Associate Professor, University of Wisconsin, Madison

  • 03/2011 - Present, Professor, University of Wisconsin, Madison

Awards and Honors

  • Second prize, 2005 Endourological Society Basic Science Essay Competition: Gyan Pareek, ER. Wilkinson, S Bharat, Tomy Varghese, PF. Laeseke, FT. Lee Jr., TF. Warner, JA. Zagzebski, SY. Nakada, Elastographic Measurements of in-vivo Radiofrequency Ablation Lesions of the Kidney, Journal of Endourology Nov 2006, Vol. 20, No. 11: 959-964.

  • Sigma Xi Research Day Best Poster Award: J. Ophir, EE Konofagou, T. Varghese, F. Kallel, S. K. Alam, and I. Cspedes, "Elastography: A quantitative method for imaging the elasticity of biological tissue", April 3, University of Houston, (1997).

  • Member, ETA Kappa Nu (Electrical Engineering Honor Society)

  • Outstanding Teacher evaluation, Letter of appreciation, Dean, University of Kentucky, Lexington, KY, 1994.

  • Recipient, Raja Ramanna Gold Medal, Best Outgoing Student, First Rank in Instrumentation Technology, University of Mysore, Mysore, India, 1988.


  • Fellow, American Institute of Ultrasound Medicine (AIUM)

  • Senior Member, Institute of Electrical and Electronics Engineers (IEEE)

  • Member, The American Association of Physicists in Medicine (AAPM).

  • Associate Member, Indian Institute of Engineers (A. M. I. E).


  • Tomy Varghese , C.S. Breburda, J.A. Zagzebski, P. S. Rahko, Method and Apparatus for Cardiac Elastography, Patent No. US 6,749,571 B2, June 15, 2004. Download/ View PDF

  • Tomy Varghese , J.A. Zagzebski, U. Techavipoo and Q. Chen, Elastographic Imaging of In-vivo soft tissue. US patent No. 7,166,075, January 23, 2007. Download/ View PDF

  • Tomy Varghese , M.A. Kliewer, J.A. Zagzebski, Method and apparatus for imaging the cervix and uterine wall, US Patent No. 7,297,116, 2007. Download/ View PDF

  • J.A. Zagzebski, Tomy Varghese , A. Gerig, Parametric Ultrasound Imaging Using Angular Compounding. US patent No.7,275,439, 2007. Download/ View PDF

  • Tomy Varghese , U. Techavipoo, Q. Chen, and J.A. Zagzebski, "Ultrasonic elastography providing axial, orthogonal, and shear strain", US Patent No. 7,331,926, 2008.

  • J.A. Zagzebski, Tomy Varghese , "Ultrasonic Elastography with Angular Compounding", US patent No.7,601,122, 2009. Download/ View PDF

  • Tomy Varghese , H. Shi, H. Chen, "High resolution elastography using two step strain estimation", US Patent No. 7,632,230, 2009. Download/ View PDF


Browse Dr. Varghese's publications on PubMed

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