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An airway tree derived from a CT scan is combined with MRI showing a prominent ventilation defect to identify a target path for bronchoscopy. Read more...
Examples of semi-automated quantification of lung ventilation defects in asthma and cystic fibrosis. Read more...
Comparison of lung ventilation defects observed using 3He MRI and O2-enhanced MRI. Read more...
  • Asthma Imaging
  • Lung Ventilation Defects
  • O2-Enhanced MRI

Pulmonary and Metabolic Imaging Center

Welcome to the Pulmonary and Metabolic Imaging Center, which includes investigators from pulmonary research, medical physics and radiology collaborating to better understand the mechanisms and regional patterns of lung diseases such as asthma, interstitial lung disease, and cystic fibrosis. The center seeks to facilitate and advance the role of imaging to improve our understanding and clinical treatment of lung disease.

Quantitative CT and novel pulmonary MRI methods are applied in concert with pulmonary function tests (PFTs), and molecular and gene expression bio-markers to better define phenotypes of lung disease and improve treatments. Quantitative image processing also plays an important role in establishing repeatable associations between clinical outcomes, such a stability of disease progression and severity, with image-based bio-markers.

Our research team is dedicated to further developing these methods to improve treatments for clinically important lung diseases such as asthma, cystic fibrosis (CF), bronchiolitis obliterans (BOS) in lung transplant, and interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF). Projects nearing completion include studies of pediatric and adult asthma using ventilation-weighted MRI and quantitative CT. Clinical research studies using these MRI techniques were conducted as part of the Severe Asthma Research Program (SARP) and childhood origins of asthma (COAST). Technical development and testing of new methods using 129Xe, a trace gas in the atmosphere that promises to be a more widely available alternative to 3He, are also ongoing. Hyperpolarized 129Xe MRI is being applied, for example, to study IPF and asthma with the goal of extending the same techniques to study pediatric asthma and CF.



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