Medical Physics Seminar – Monday, August 27, 2012
Experimental Design to Study the Spatial and Temporal Fidelity of HYPR Reconstruction and A Behind Scenes Look at the Imaging Facility at Fort Detrick Army Base, MD
Lauren Keith (student of Drs. Charles Mistretta and Frank Korosec)
Research Assistant, Department of Medical Physics, UW-School of Medicine & Public Health, Madison, WI - USA -
In the first half of the seminar, we’ll discuss an experiment designed to further characterize the spatial and temporal fidelity of HYPR reconstruction using real, acquired, three-dimensional data and a computer controlled motion phantom to simulate the passage of contrast-enhanced blood through an artery and vein. The goal of this experimental set-up was not only to imitate in vivo scenarios, but also to provide well-defined temporal dynamics and spatial characteristics.
The phantom was designed to represent an artery flanked on both sides by vein. Both arterial and venous components have different temporal dynamics but are confluent, which corresponds to a difficult scenario for HYPR. Spatial and temporal fidelity was investigated by measuring signal intensity profiles through the phantom in the direction orthogonal to the motion and in the direction of motion, respectively.
While this experiment was specifically designed to mimic a peripheral MRA examination, we believe these findings to be applicable to a broad range of anatomical regions with similar spatio-temporal correlation and sparsity where HYPR might be applied.
In the second half of the seminar, we’ll discuss the new Integrated Research Facility at Fort Detrick, Maryland. Part of the National Institute of Allergy and Infectious Disease/National Institutes of Health, this facility is the first of its kind: integrating medical imaging into infectious disease research.