Medical Physics Seminar – Monday, October 31, 2016
Positron-Emitting Isotopes of Manganese and Applications Thereof
Stephen Graves (student of Dr. R.J. Nickles)
Research Assistant, Dept of Medical Physics, UW-School of Medicine & Public Health, Madison, WI - USA
Manganese is an essential trace element in mammalian biology and has many prospective applica-tions as an imaging agent in both PET and MRI including cell tracking, neural tract tracing, im-munoPET, and β-cell mass quantification. Of the three positron-emitting isotopes of manganese, 52gMn (t1/2: 5.6 d, β+: 29%) is best suited to preclinical research and 51Mn (t1/2: 46 min, β+: 97%) is best suited to clinical PET based on decay characteristics. Robust methods for the preparation of 51Mn and 52gMn on low-energy medical cyclotrons are essential to the investigation of basic science and clinical questions relating to the biological role of manganese in disease. This talk will detail the development of radiomanganese preparation methods and briefly describe preclinical imaging results in a mouse model of type-I diabetes.