Medical Physics Seminar – Monday, October 23, 2017
Bioreactor Development for Multi-Scale Measurement of Tumor Metabolism
Benjamin Cox, MS (student of Dr. Sean Fain)
Research Assistant, Department of Medical Physics, UW-School of Medicine & Public Health, Madison, WI - USA
The design and fabrication of a novel bioreactor capable of facilitating both magnetic resonance spectroscopy (MRS) and optical fluores-cence microscopy is described. Fluorescence lifetime imaging (FLIM) of nicotinamide adenine dinucleotide (NADH) and hyperpolarized [1-13C] pyruvic acid (PA) MRS of a mouse breast cancer line in a 3D col-lagen matrix is demonstrated. In particular, the effect of glucose-starvation is examined as a proof of principle application. The system provides a novel test-bed for simulating cell-matrix and cell-cell inter-actions in a 3D microenvironment for investigating multi-scale cellular metabolism in vitro.
Finite-Element Model of Multiple Antenna Microwave Ablation: Impact of High-Power Modulation
Mariajose Bedoja (student of Dr. Christopher Brace)
Research Assistant, Department of Medical Physics, UW-School of Medicine & Public Health, Madison, WI - USA
Microwave ablation is a minimally invasive percutaneous treatment for liver malignancies. Compared to other ablation modalities, micro-waves create faster heating, larger and more consistent ablations. However, local tumor progression still remains a challenge in micro-wave ablation procedures. Improvement in high-power delivery tech-niques with single and multiple antenna application may create larger ablation zones to improve local control. This talk will present the re-sults and validation of high power modulation using a finite-element model of microwave ablation compared to continuous power delivery using multiple antenna applicators.