Medical Physics Seminar – Monday, September 17, 2018
Tools for Multiscale Imaging of Collagen in Cancer
Michael A. Pinkert, M.S. (student of Dr. Walter Block and Dr. Kevin Eliceiri)
Research Assistant, Department of Medical Physics, UW-School of Medicine & Public Health, Madison, WI - USA
The organization of collagen fibers plays an important role in many types of cancer, from microscale fiber structure affecting cellular processes such as metastasis, to macroscale density in organs being a component of cancer risk. However, there is a lack of accessible tools that can study collagen across multiple spatial scales, making it difficult to fully understand the effects of collagen organization on cancer. This talk introduces hardware and software tools to perform multiscale imaging of collagen. This includes a platform that combines ultrasound and second-harmonic-generation microscopy, alongside software that can register and analyze collagen across large volumes.