Medical Physics Seminar – Monday, November 22, 2010
A Whole-Body Pharmacokinetic Model for the Early Assessment of Targeted Radionuclide Therapy Agents
Joseph Grudzinski (student of Dr. Robert Jeraj)
Research Assistant, Department of Medical Physics, UW-School of Medicine & Public Health, Madison, WI USA
Early assessment of targeted radionuclide therapy (TRT) agent effectiveness based on its pharmacokinetic (PK) properties could provide a means to expedite agent development or rejection. A whole-body PK model was developed that not only simplifies the complex radiation dosimetry and physiology of TRT but also provides criteria for normal tissue and tumor PK parameters that achieve effective TRT while limiting toxicity.<br />
The model can compare absorbed doses as well as biologically effective doses (BED) of different TRT agents. Two potential TRT agents were compared using this model. To assess the applicability and limitations of the model, both sensitivity and uncertainty analysis were performed.