Department of Medical Physics
University of Wisconsin School of Medicine and Public Health

Todd E. Barnhart

Credentials: Ph.D.

Position title: Senior Scientist, Director of PET Cyclotron Physics

Email: tebarnhart@wisc.edu

Phone: (608) 262-2834

Address:
B1137 WIMR

Education

B.S., Nuclear Engineering, University of New Mexico

B.S., Physics, Metropolitan State College of Denver, CO

M.S., Medical Physics, University of Colorado, Denver, CO

Ph.D., Medical Physics, University of Wisconsin, Madison, WI

Department Affilations

Medical Physics

Positions

  • 1999-2000, Researcher, Nuclear Cardiology Research, Inc., Denver, CO
  • 2000-2004, Research Assistant, Medical Physics, University of Wisconsin, Madison, WI
  • 2004-2008, Head of Cyclotron Radioisotope Production and Delivery, Wolfson Molecular Imaging Centre, University of Manchester, UK
  • 2008-2016, Associate Scientist, Director of Cyclotron Physics, Department of Medical Physics, University of Wisconsin-Madison, WI
  • 2016-present, Senior Scientist, Director of Cyclotron Physics, Department of Medical Physics, University of Wisconsin-Madison, WI

Publications

  • Betthauser, T. J., Ellison, P. A., Murali, D., Lao, P. J., Barnhart, T. E., Furumoto, S., Okamura, N., Johnson, S. C., Engle, J. W., Nickles, R. J., Christian, B. T. Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau. Appl Radiat Isot. 2017
  • Valdovinos, H. F., Hernandez, R., Graves, S., Ellison, P. A., Barnhart, T. E., Theuer, C. P., Engle, J. W., Cai, W., Nickles, R. J. Cyclotron production and radiochemical separation of 55Co and 58mCo from 54Fe, 58Ni and 57Fe targets. Appl Radiat Isot. 2017
  • Cheng, L., Jiang, D. W., Kamkaew, A., Valdovinos, H. F., Im, H. J., Feng, L. Z., England, C. G., Goel, S., Barnhart, T. E., Liu, Z., Cai, W. B. Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-Guided Photodynamic Cancer Therapy. Advanced Functional Materials 2017 27(34)
  • Hernandez R, England CG, Yang Y, Valdovinos HF, Liu B, Wong HC, Barnhart TE, Cai W. ImmunoPET imaging of tissue factor expression in pancreatic cancer with 89Zr-Df-ALT-836. J Control Release. 2017
  • England CG, Jiang D, Ehlerding EB, Rekoske BT, Ellison PA, Hernandez R, Barnhart TE, McNeel DG, Huang P, Cai W. 89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer. Eur J Nucl Med Mol Imaging. 2017
  • Koziolová, E., Goel, S., Chytil, P., Janoušková, O., Barnhart, T. E., Cai, W., Etrych, T. A. tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging. Nanoscale. 2017 9(30):10906-10918
  • Graves, S. A., Ellison, P. A., Valdovinos, H. F., Barnhart, T. E., Nickles, R., J., Engle, J. W. Half-life of 51Mn. Phys. Rev. C 96(), 2017
  • Lao, P. J., Handen, B. L., Betthauser, T. J., Mihaila, I., Hartley, S. L., Cohen, A. D., Tudorascu, D. L., Bulova, P. D., Lopresti, B. J., Tumuluru, R. V., Murali, D., Mathis, C. A., Barnhart, T. E., Stone, C. K., Price, J. C., Devenny, D. A., Mailick, M. R., Klunk, W. E., Johnson, S. C., Christian, B. T. Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population. Alzheimers Dement. 2017
  • Graves, S. A,, Hernandez, R., Valdovinos, H. F., Ellison, P. A., Engle, J. W., Barnhart, T. E., Cai, W., Nickles, R. J. Preparation and in vivo characterization of 51MnCl2 as PET tracer of Ca2+ channel-mediated transport. Sci Rep. 2017 7(1):3033
  • Ehlerding, E. B., England, C. G., Jiang, D., Graves, S. A., Kang, L., Lacognata, S., Barnhart, T. E., Cai, W. CD38 as a PET Imaging Target in Lung Cancer. Mol Pharm. 2017
  • Hernandez, R., Graves, S. A., Gregg, T., VanDeusen, H. R., Fenske, R. J., Wienkes, H. N., England, C. G., Valdovinos, H. F., Jeffery, J. J., Barnhart, T. E., Severin, G. W., Nickles, R. J., Kimple, M. E., Merrins, M. J., Cai, W. Radiomanganese PET Detects Changes in Functional β-cell Mass in Mouse Models of Diabetes. Diabetes. 2017 66(8):2163-2174
  • Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT. [18F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors. Synapse. 2017 71(8)
  • Ni D, Jiang D, Valdovinos HF, Ehlerding EB, Yu B, Barnhart TE, Huang P, Cai W. Bioresponsive Polyoxometalate Cluster for Redox-Activated Photoacoustic Imaging-Guided Photothermal Cancer Therapy. Nano Lett. 2017 17(5):3282-3289
  • Chen F, Valdovinos HF, Hernandez R, Goel S, Barnhart TE, Cai W. Intrinsic radiolabeling of Titanium-45 using mesoporous silica nanoparticles. Acta Pharmacol Sin. 2017 38(6):907-913
  • Ellison, P. A., Chen, F., Goel, S., Barnhart, T. E., Nickles, R. J., DeJesus, O. T., Cai, W. Intrinsic and Stable Conjugation of Thiolated Mesoporous Silica Nanoparticles with Radioarsenic. ACS Appl Mater Interfaces. 2017, 9(8): 6772-6781
  • Betthauser, T., Lao, P. J., Murali, D., Barnhart, T. E., Furumoto, S., Okamura, N., Stone, C. K., Johnson, S. C., Christian, B. T. In vivo comparison of tau radioligands 18F-THK-5351 and 18F-THK-5317. J Nucl Med. 2016
  • Ellison, P. A., Valdovinos, H. F., Graves, S. A., Barnhart, T. E., Nickles, R. J. Spot-welding solid targets for high current cyclotron irradiation. Appl Radiat Isot. 2016 118:350-353
  • Yang, D., Severin, G. W., Dougherty, C. A., Lombardi, R., Chen, D., Van Dort, M. E., Barnhart, T. E., Ross, B.D., Mazar, A .P., Hong, H. Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging. Oncotarget. 2016 7(45): 73912-73924
  • Graves, S. A., Ellison, P. A., Barnhart, T. E., Valdovinos, H. F., Birnbaumb, E. R., Nortier, F. M., Nickles, R. J., Engle, J. W. Nuclear excitation functions of proton-induced reactions (Ep = 35–90 MeV) from Fe, Cu, and Al. Nucl. Instr. Methods B, 2016 386: 44–53
  • Kamkaew, A., Cheng, L., Goel, S., Valdovinos, H. F., Barnhart, T. E., Liu, Z., Cai, W. Cerenkov Radiation Induced Photodynamic Therapy Using Chlorin e6-Loaded Hollow Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2016 8:26630−26637
  • Cheng, L., Kamkaew, A., Shen, S., Valdovinos, H. F., Sun, H., Hernandez, R., Goel, S., Liu, T., Thompson, C. R., Barnhart, T. E., Liu, Z., Cai, W. Facile Preparation of Multifunctional WS2 /WOx Nanodots for Chelator-Free 89Zr-Labeling and In Vivo PET Imaging. Small. 2016 12(41):5750-5758
  • Hernandez, R., Sun, H., England, C. G., Valdovinos, H. F., Ehlerding, E. B., Barnhart, T. E., Yang, Y., Cai, W. CD146-targeted immunoPET and NIRF Imaging of Hepatocellular Carcinoma with a Dual-Labeled Monoclonal Antibody. Theranostics. 2016 6(11):1918-33
  • Goel, S., Chen, F., Luan, S., Valdovinos, H. F., Shi, S., Graves, S. A., Ai, F., Barnhart, T. E., Theuer, C. P., Cai, W. Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies. Adv. Sci. 2016, 3, 1600122
  • England, C. G., Ehlerding, E. B., Hernandez, R., Rekoske, B. T., Graves, S. A., Sun, H., Liu, G., McNeel, D. G., Barnhart, T. E., Cai, W. Preclinical Pharmacokinetics and Biodistribution Studies of 89Zr-labeled Pembrolizumab. J Nucl Med. 2016
  • Cox, B. L., Graves, S. A. Farhoud, M., Barnhart, T. E. Jeffery, J. J., Eliceieri, K. W., Nickles, R. J. Development of a novel linearly-filled Derenzo microPET phantom. Am J Nucl Med Mol Imaging 2016 6(3):199-204
  • Cheng, .L, Kamkaew, A., Sun, H., Jiang, D., Valdovinos, H. F., Gong, H., England, C. G., Goel, S., Barnhart, T. E., Cai, W. Dual-Modality Positron Emission Tomography/Optical Image-Guided Photodynamic Cancer Therapy with Chlorin e6-Containing Nanomicelles. ACS Nano. 2016 10(8):7721-30
  • Sun, H., England, C. G., Hernandez, R., Graves, S. A., Majewski, R. L., Kamkaew, A., Jiang, D., Barnhart, T. E., Yang, Y., Cai, W. ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer. Eur J Nucl Med Mol Imaging. 2016 43:2169-2179
  • Zhang, Y., Wang, D., Goel, S., Sun, B., Chitgupi, U., Geng, J., Sun, H., Barnhart, T. E., Cai W, Xia, J., Lovell, J. F. Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging. Adv Mater. 2016
  • Croce, M. P., Rabin, M. W., Mocko, V., Kunde, G. J. Birnbaum, E. R. Bond, E. M., Engle, J. W., Hoover, A. S., Nortier, F. M., Pollington, A. D., Taylor, W. A., Weisse-Bernstein, N. R., Wolfsberg, L. E., Hays-Wehle, J. P., Schmidt, D. R., Swetz, D. S., Ullom, J. N., Barnhart, T. E., Nickles, R. J. Development of Holmium-163 Electron-Capture Spectroscopy with Transition-Edge Sensors. J Low Temp Phy 2016 184(3-4): 958-968
  • Hernandez, R., Sun, H., England, C. G., Valdovinos, H. F., Barnhart, T. E., Yang, Y., Cai, W. ImmunoPET Imaging of CD146 Expression in Malignant Brain Tumors. Mol Pharm. 2016 13(7):2563-70
  • Smith, A. L., Freeman, S. M., Barnhart, T. E., Abbott, D. H., Ahlers, E. O., Kukis, D. L., Bales, K. L., Goodman, M. M., Young, L. J. Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys. Bioorg Med Chem Lett. 2016 26(14): 3370-3375
  • Cheng, L., Shen, S. D., Shi, S. X., Yi, Y., Wang, X. Y., Song, G. S., Yang, K., Liu, G., Barnhart, T. E., Cai, W. B. FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free Cu-64-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy. Adv Funct Mater 2016 26(13): 2185-2197
  • Zhan, Y., Ai, F., Chen, F., Valdovinos, H. F., Orbay, H., Sun, H., Liang, J., Barnhart, T. E., Tian, J., Cai W. Intrinsically Zirconium-89 Labeled Gd2 O2 S:Eu Nanoprobes for In Vivo Positron Emission Tomography and Gamma-Ray-Induced Radioluminescence Imaging. Small. 2016 12(21):2872-6
  • England, C. G., Kamkaew, A., Im, H. J., Valdovinos, H. F., Sun, H., Hernandez, R, Cho S. Y, Dunphy, E. J., Lee, D. S., Barnhart, T. E., Cai, W. ImmunoPET imaging of insulin-like growth factor 1 receptor (IGF-1R) in a subcutaneous mouse model of pancreatic cancer. Mol Pharm. 2016 13(6): 1958-1966
  • Racine, A. M., Koscik, R. L., Nicholas, C. R., Clark, L. R., Okonkwo, O. C., Oh, J. M., Hillmer, A. T., Murali, D., Barnhart, T. E., Betthauser, T. J., Gallagher, C L., Rowley, H. A., Dowling, N. M., Asthana, S., Bendlin, B. B., Blennow, K., Zetterberg,. H., Carlsson, C. M., Christian, B. T., Johnson, S. C. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation. Alzheimers Dement 2016 2:27-38
  • Ellison, P.A., Barnhart, T. E., Chen, F., Hong, H., Zhang, Y., Theuer, C. P., Cai, W.B., Nickles, R. J., DeJesus, OT. High Yield Production and Radiochemical Isolation of Isotopically Pure Arsenic-72 and Novel Radioarsenic Labeling Strategies for the Development of Theranostic Radiopharmaceuticals. Bioconjug Chem. 2016 27(1): 179-188
  • Shi S., Fliss, B. C., Gu, Z., Zhu, Y., Hong, H., Valdovinos H. F., Hernandez, R., Goel, S., Luo, H., Chen, F., Barnhart, T. E., Nickles, R.J., Xu, Z. P., Cai, W. Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging. Sci Rep. 2015 20(5):1693
  • Mocko, V., Taylor, W. A., Nortier, F. M. Engle, J. W., Barnhart, T. E., Nickles, R. J., Pollington, A. D., Kunde, G. J.,; Rabin, M. W., Birnbaum, E. R. Isolation of Ho-163 from dysprosium target material by HPLC for neutrino mass measurements. Radiochimica Acta. 2015 103(8): 577-585
  • Graves, S. A , Hernandez, R., Fonslet, J., England, C. G., Valdovinos, H. F., Ellison, P. A., Barnhart, T. E, Elema, D. R., Theuer, C. P., Cai, W., Nickles, R. J., Severin, G. W. Novel Preparation Methods of 52Mn for ImmunoPET Imaging. Bioconjug Chem. 2015 26(10):2118-24
  • Chen, F., Goel, S., Valdovinos, H. F., Luo, H., Hernandez, R., Barnhart, T. E., Cai, W. In Vivo Integrity and Biological Fate of Chelator-Free Zirconium-89-Labeled Mesoporous Silica Nanoparticles. ACS Nano. 2015 9(8):7950-9.
  • Doherty, B. M., Schultz, S. A., Oh, J. M., Koscik, R. L., Dowling, N. M., Barnhart, T. E., Murali, D., Gallagher, C. L., Carlsson, C. M., Bendlin, B. B., LaRue, A., Hermann, B. P., Rowley, H. A., Asthana, S., Sager, M. A., Christian, B. T., Johnson, S. C., Okonkwo, O. C. Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer’s Prevention. Alzheimers Dement. 2015 1(2):160-169.
  • Lao, P. J., Betthauser, T. J., Hillmer, A. T., Price, J. C., Klunk, W. E., Mihaila, I., Higgins, A. T., Bulova, P. D., Hartley, S. L., Hardison, R., Tumuluru, R.V., Murali, D., Mathis, C. A., Cohen, A. D., Barnhart, T. E., Devenny, D. A., Mailick, M. R., Johnson, S. C., Handen, B. L., Christian, B. T. The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B. Alzheimers Dement. 2015 12(4):380-90
  • Chakravarty, R., Goel, S., Hong, H., Chen, F., Valdovinos, H. F., Hernandez, R., Barnhart, T. E., Cai, W. Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery. Nanomedicine. 2015 10(8):1233-46.
  • Converse, A. K., Ahlers, E. O., Bryan, T. W., Hetue, J. D., Lake, K. A., Ellison, P. A., Engle, J. W., Barnhart, T. E., Nickles, R. J., Williams, P. H., DeJesus, O. T. Mathematical modeling of positron emission tomography (PET) data to assess radiofluoride transport in living plants following petiolar administration. Plant Methods. 2015 11:18
  • Liu, T., Shi, S., Liang, C., Shen, S., Cheng, L., Wang, C., Song, X., Goel, S., Barnhart, T. E., Cai, W., Liu, Z. Iron Oxide Decorated MoS2 Nanosheets with Double PEGylation for Chelator-Free Radiolabeling and Multimodal Imaging Guided Photothermal Therapy. ACS Nano. 2015 9(1):950-60
  • Lewis, C. M., Graves, S. A., Hernandez, R., Valdovinos, H. F., Barnhart, T. E., Cai, W., Meyerand, M. E., Nickles, R. J., Suzuki, M. 52Mn Production for PET/MRI Tracking Of Human Stem Cells Expressing Divalent Metal Transporter 1 (DMT1). Theranostics. 2015 5(3):227-39
  • Shi, S., Yang, K., Hong, H., Chen, F., Valdovinos, H. F., Goel, S., Barnhart, T. E., Liu, Z., Cai, W. VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo. Biomaterials. 2015 39:39-46
  • Converse, A. K., Moore, C. F., Holden, J. E., Ahlers, E. O., Moirano, J. M., Larson, J. A., Resch, L. M., DeJesus, O. T., Barnhart, T. E., Nickles, R. J., Murali, D., Christian, B. T., Schneider, M. L. Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys. Alcohol Clin Exp Res. 2014 38(12):2934-43
  • Valdovinos, H. F., Hernandez, R., Barnhart, T. E., Graves, S., Cai, W., Nickles, R. J. Separation of cyclotron-produced 44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin. Appl Radiat Isot. 2014 95:23-29
  • Hillmer, A.T., Wooten, D. W., Bajwa, A. K., Higgins, A. T., Lao, P. J., Betthauser, T. J., Barnhart, T. E., Rowley, H. A., Stone, C. K., Johnson, S. C., Mukherjee, J., Christian, B. T. First-in-Human Evaluation of 18F-Mefway, a PET Radioligand Specific to Serotonin-1A Receptors. J Nucl Med. 2014 55(12):1973-9
  • Goel, S., Chen, F., Hong, H., Valdovinos, H. F., Hernandez, R., Shi, S., Barnhart, T. E., Cai, W. VEGF121-Conjugated Mesoporous Silica Nanoparticle: A New Tumor Targeted Drug Delivery System. ACS Appl Mater Interfaces. 2014 6(23):21677-85
  • Hillmer, A. T., Wooten, D. W., Tudorascu, D. L., Barnhart, T. E., Ahlers, E. O., Resch, L..M., Larson, J. A., Converse, A. K., Moore, C. F., Schneider, M. L., Christian, B. T. The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates. Drug Alcohol Depend. 2014 144:119-26
  • Hong, H., Nayak, T. R., Shi, S., Graves, S. A., Fliss, B. C., Barnhart, T. E., Cai, W. Generation and Screening of Monoclonal Antibodies for ImmunoPET Imaging of IGF1R in Prostate Cancer. Mol Pharm. 2014 11(10):3624-30
  • Wooten, D. W., Hillmer, A. T., Murali, D., Barnhart, T. E., Thio, J. P., Bajwa, A. K., Bonab, A. A., Normandin, M. D., Schneider, M. L., Mukherjee, J., Christian, B. T. Initial in vivo PET imaging of 5-HT1A receptors with 3-[18F]mefway. Am J Nucl Med Mol Imaging. 2014 4(5):483-9.
  • Hernandez, R., Valdovinos, H. F., Yang, Y. N., Chakravarty, R. Hong, H. Barnhart, T. E., Cai, W. B. Sc-44: An Attractive Isotope for Peptide-Based PET Imaging. Mol Pharm. 2014 11(8): 2954-2961
  • Zhang, Y., Jeon, M., Rich, L. J., Hong, H., Geng J., Zhang, Y., Shi, S., Barnhart, T. E, Alexandridis, P., Huizinga, J. D., Seshadri, M., Cai, W., Kim, C., Lovel, J. F. Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines. Nat Nanotechnol. 2014 9(8): 631-638
  • Chen, F., Nayak, T. R., Goel, S., Valdovinos, H. F., Hong, H., Theuer, C. P., Barnhart, T. E., Cai, W. In Vivo Tumor Vasculature Targeted PET/NIRF Imaging with TRC105(Fab)-conjugated, Dual-labeled Mesoporous Silica Nanoparticles. Mol Pharm. 2014 11(11): 4007-4014
  • Racine, A. M., Adluru, N., Alexander, A. L., Christian, B. T., Okonkwo, O. C., Oh, J., Cleary, C A., Birdsill, A., Hillmer, A. T., Murali, D., Barnhart, T. E., Gallagher, C. L., Carlsson, C. M., Rowley, H. A., Dowling, N. M., Asthana, S., Sager, M. A., Bendlin, B. B., Johnson, S. C. Associations between white matter microstructure and amyloid burden in preclinical Alzheimer’s disease: A multimodal imaging investigation. Neuroimage Clin. 2014 4:604-14
  • Chen, F., Hong, H., Shi, S., Goel, S., Valdovinos, H. F., Hernandez, R., Theuer, C. P., Barnhart, T. E., Cai, W. Engineering of Hollow Mesoporous Silica Nanoparticles for Remarkably Enhanced Tumor Active Targeting Efficacy. Scientific Reports 2014 4 Article 5080
  • Peng Y., Li M., Clarkson B. D., Pehar M., Lao P. J., Hillmer A. T., Barnhart T. E., Christian B. T., Mitchell H. A., Bendlin B. B., Sandor M., Puglielli L.. Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer. J Neurosci. 2014 34(20):6772-89
  • Guo, J., Hong, H., Chen, G., Shi, S., Nayak, T. R., Theuer, C. P., Barnhart, T. E., Cai, W., Gong, S. Theranostic Unimolecular Micelles Based on Brush-Shaped Amphiphilic Block Copolymers for Tumor-Targeted Drug Delivery and Positron Emission Tomography Imaging. ACS Appl Mater Interfaces. 2014 6(24): 21769-21779
  • Okonkwo, O. C., Oh, J. M., Koscik, R., Jonaitis, E, Cleary, C. A., Dowling, N. M., Bendlin, B. B., Larue, A., Hermann, B. P., Barnhart, T. E., Murali, D., Rowley, H. A., Carlsson, C. M., Gallagher, C. L., Asthana, S., Sager, M. A., Christian, B. T., Johnson, S. C. Amyloid Burden, Neuronal Function, and Cognitive Decline in Middle-Aged Adults at Risk for Alzheimer’s Disease. J Int Neuropsychol Soc. 2014. 20(4): 422-433
  • Hillmer, A. T., Tudorascu, D. L., Wooten, D. W., Lao, P. J., Barnhart, T. E., Ahlers, E. O., Resch, L. M., Larson, J. A., Converse, A. K., Moore, C. F., Schneider, M. L., Christian, B. T.. Changes in the α4β2* nicotinic acetylcholine system during chronic controlled alcohol exposure in nonhuman primates. Drug Alcohol Depend. 2014, 138: 216-219
  • Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J., Harding, S., Xu, G., Hillmer, A. T., Wooten, D. W., Murali, D., Barnhart, T., Hall, L. T., Racine, A. M., Klunk, W. E., Mathis, C. A., Bendlin, B. B., Gallagher, C. L., Carlsson, C. M., Rowley, H. A., Hermann, B. P., Dowling, N. M., Asthana, S., Sager, M. A. Amyloid burden and neural function in people at risk for AD. Neurobiology of Aging 2014, 35(3): 576-584
  • Orbay, H., Hong, H., Koch, J. M., Valdovinos, H. F., Hacker, T. A., Theuer, C. P., Barnhart, T. E., Cai, W. Pravastatin stimulates angiogenesis in a murine hindlimb ischemia model: a positron emission tomography imaging study with 64Cu-NOTA-TRC105. Am J Transl Res. 2013, 6(1):54-63
  • Chen, F., Ellison, P. A., Lewis, C. M., Hong, H., Zhang, Y., Shi, S., Hernandez, R., Meyerand, M. E., Barnhart, T. E., Cai, W. Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent. Angew Chem Int Ed Engl. 2013, 52(50): 13319-13323
  • Hillmer, A. T., Wooten, D. W., Slesarev, M. S., Ahlers, E. O., Barnhart, T. E., Schneider, M. L., Mukherjee, J., Christian, B. T. Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [18F]nifene PET in the nonhuman primate. J Cereb Blood Flow Metab. 2013, (12): 882-886
  • Hillmer, A. T., Wooten, D. W., Farhoud, M., Higgins, A. T., Lao, P., Barnhart, T. E., Mukherjee, J., Christian, B. T. PET imaging of acetylcholinesterase inhibitor induced effects on α4β2 nicotinic acetylcholine receptor binding. Synapse. 2013, 67(12): 882-886
  • Guo, J., Hong, H., Chen, G., Shi, S., Zheng, Q., Zhang, Y., Theuer, C. P., Barnhart, T. E., Cai, W., Gong S. Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles. Biomaterials. 2013, 34(33): 8323-8332
  • Chen, F., Hong, H., Zhang, Y., Valdovinos, H. F., Shi, S. X., Kwon, G. S., Theuer, C. P., Barnhart, T. E., Cai, W. In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radio labeled Mesoporous Silica Nanoparticles. ACS Nano. 2013, 7(10): 9027-9039
  • Orbay, H., Zhang, Y., Hong, H., Hacker, T. A., Valdovinos, H. F., Zagzebski, J. A., Theuer, C.P, Barnhart, T. E, Cai W. Positron Emission Tomography Imaging of Angiogenesis in a Murine Hindlimb Ischemia Model with 64Cu-Labeled TRC105. Mol Pharm. 2013
  • Converse, A. K., Moore, C. F., Moirano, J. M., Ahlers, E. O., Larson, J. A., Engle, J. W., Barnhart, T. E., Murali, D., Christian, B. T., DeJesus, O. T., Holden, J. E., Nickles, R. J., Schneider, M. L. Prenatal Stress Induces Increased Striatal Dopamine Transporter Binding in Adult Nonhuman Primates, Biological Psychiatry, 2013, 74(7):502-10
  • Converse, A. K., Ahlers, E. O., Bryan, T. W., Williams, P. H., Barnhart, T. E., Engle, J. W., Nickles, R. J., DeJesus, O. T. Positron emission tomography (PET) of radiotracer uptake and distribution in living plants: methodological aspects. J. Radioanalytical and Nuclear Chemistry 2013 297(2): 241-246
  • Zhang, Y., Hong, H., Nayak, T. R., Valdovinos, H. F., Myklejord, D. V., Theuer, C. P., Barnhart, T. E., Cai, W. Erratum to: Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence. Angiogenesis. 2013, 16(3): 663-674
  • Hong, H., Benink, H. A., Uyeda, H. T., Valdovinos, H. F., Zhang, Y., Meisenheimer, P., Barnhart, T. E., Fan, F., Cai, W. HaloTag as a reporter gene: positron emission tomography imaging with (64)Cu-labeled second generation HaloTag ligands. Am J Transl Res. 2013, 5(3):291-302
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  • Engle, J. W., Severin, G. W., Barnhart, T. E., Knutson, L. D., Nickles, R. J. Cross sections of the 36Ar(d,α)34mCl, 40Ar(d,α)38Cl, and 40Ar(d,p)41Ar nuclear reactions below 8.4 MeV. Appl Radiat Isot 2012; 70(2):355-359
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  • Bartlett, R. M., Murali, D., Nickles, R. J., Barnhart, T. E., Holden, J. E., DeJesus, O. T., Assessment of Fetal Brain Uptake of Paraquat In Utero Using In Vivo PET/CT Imaging. Tox Sci 2011; 122(2):551-558
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  • Converse, A. K. Larsen, E. C., Engle, J. W., Barnhart, T. E., Nickles, R. J., Duncan, I. D., 11C-(R)-PK11195 PET Imaging of Microglial Activation and Response to Minocycline in Zymosan-Treated Rats. J Nucl Med 2011; 52(2):257-262
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Memberships

  • Society of Nuclear Medicine
  • Society of Radiopharmaceutical Sciences