University of Wisconsin–Madison

Radiological Sciences Training Grant

Goals

The Radiological Sciences Training Grant supports Ph.D. and postdoctoral research related to cancer. The goal of this training program is to prepare physicists and engineers for research careers in radiological physics and dosimetry as well as in functional, anatomical, and interventional medical imaging as it applies to the detection and treatment of cancer.

Faculty trainers in this program are committed to excellence in research broadly applied to cancer treatment, diagnosis, and prevention. We take a multi-disciplinary approach that is strongly image-science based and is increasingly molecular-focused. Trainees are immersed in this comprehensive research environment. Research training is available in every major area of physics involved with cancer treatment and diagnosis, cancer biology, and in emerging areas of molecular imaging.

Administration

Principal Investigator: Timothy Hall, Ph.D.

Administrator: Carol Aspinwall

Appointments

The Radiological Sciences Training grant supports 8 predoctoral trainees and 3 postdoctoral trainees. About 4-5 training grant openings are filled each year to replace individuals rotating off because of graduation or completion of training. Nominations for training grant positions are made by either the student’s advisor or the faculty advisor/sponsor in the case of postdoctoral nominations. Nominations include a description of the area of research, the cancer relevance, and an agreement that the student will fulfill the requirements of the training grant, detailed below. In most cases students must have reached dissertator status to be considered for a training grant position. To assure that a broad research area is included amongst trainees, faculty members will generally not have more than one advisee on the grant.

Appointment Requirements include the following:

  • Thesis research must be focused on the broad area of diagnosis, treatment, or treatment monitoring of cancer
  • Trainees must have had, or be enrolled in, a course in cancer biology
  • Trainees must have had, or be enrolled in, a course in research ethics training
  • Trainees must participate in the annual Radiological Physics Training Grant symposium; in addition, trainees must prepare a progress report each spring.
  • Authors of papers and theses must acknowledge partial support of the training grant in their publications
  • Appointments cannot exceed 5 years for predoctoral trainees and 3 years for postdoctoral trainees. Because of previous courses taken and research work completed, most predoctoral dissertators complete their work in 2 years.
  • Postdoctoral training includes preparing a K-series or an R series NIH grant application

Application forms are available for predoctoral appointees and postdoctoral research fellows.

Acknowledgement Requirements

Each publication, press release, or other document about research supported by an NIH award must include an acknowledgment of NIH award support and a disclaimer such as:

“Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number T32CA009206. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

Prior to issuing a press release concerning the outcome of this research, please notify the NIH awarding IC in advance to allow for coordination.

Current Trainees and their Projects

Postdocs

Date Appointed Name Advisor Research
6/1/2017 Dr. Camille Garcia-Ramos Dr. Elizabeth Meyerand Using innovative analysis methods and applying machine learning techniques to clinical and neuroimaging measures to identify predictors of primary and functional outcomes in brain tumor patients
5/1/2017 Dr. Annelise Malkus Dr. Sean Fain Can diffusion weighted MRI delineate microstructural dimensions in inflammatory lung disease?
9/1/2018 Dr. Paul Begovatz Dr. Sean Fain Use hyperpolarized Carbon-13 magnetic resonance spectroscopy (13C-MRS), spectroscopic imaging (13C-MRSI), and fluorescence lifetime imaging microscopy (FLIM) to non-invasively investigate the interplay of collagen with cellular metabolism in breast cancer.

Pre-docs

Date Appointed Name Advisor Research
5/1/2017 Carson Hoffman Dr. Oliver Wieben Quantitative 4D Flow: Applications in abdominal cancers
5/1/2017 Sabrina Hoffman Dr. Bruce Thomadsen Bromine Auger electrons as a potential therapeutic agent for prostate cancer therapy
6/1/2017 Andrew Santoso Dr. Tim Hall Characterizing the Cervix Microstructure with Model-Based Quantitative Ultrasonic
9/1/2017 Emily Ehlerding Dr. Weibo Cai Molecular imaging for personalized immunotherapy
5/1/2018 Leonard Che Fru Dr. Larry DeWerd Development of an optical device that measures hemodynamics in a tumor
5/1/2018 Alex Antolak Dr. Edward Jackson Development of a framework for the quantitative assessment of treatment response and outcome prediction in head and neck PET/MRI

PAST PREDOCTORAL TRAINEES AND THEIR DISSERTATIONS

(2012 – present)

Graduation Year Name Advisor Dissertation Title
2018 Tobey Betthauser Dr. Bradley Christian Investigation of Novel Positron Emission Tomography Radioligands for In Vivo Characterization of Alzheimer’s Disease Pathophysiology
2018 Lindsey Drehfal Dr. Timothy Hall Characterizing the Human Uterine Cervix using Quantitative Ultrasound and Second Harmonic Generation Microscopy Imaging
2018 Quinton Guerrero Dr. Timothy Hall On the Use of the Rhesus Macaque Model for Ultrasonic Backscatter Parameters in the Human Cervix
2018 Kai Ludwig Dr. Sean Fain Development of quantitative magnetic resonance imaging techniques for cellular tracking and measuring organ function
2018 Andrew Shepard Dr. Bryan Bednarz An ultrasound-based motion management system utilizing 2D/3D real-time tracking for use in radiotherapy
2017 Kirby Campbell Dr. Paul Campagnola True 3D Second Harmonic Generation Imaging and Optical Scattering Determination for Detecting Fibrillary Collagen Alterations in Ovarian Cancer
2017 David Campos Dr. Michael Kissick Radiation Induces Live-Cell Metabolic Fluxes: an In-Vitro Demonstration
2017 Stephen Graves Dr. Robert Nickles Production and Applications of Long-Lived Positron-Emitting Radionuclides
2017 Samantha Simiele Dr. Larry DeWerd Advancements in Electronic Brachytherapy Dosimetry Methods
2016 Camille Garcia-Ramos Dr. Vivek Prabhakaran Graph Theory on Neuroanatomical and Neurofunctional Development in New-Onset Pediatric Epilepsy
2016 Stephanie Harmon Dr. Robert Jeraj Molecular Imaging Biomarkers of Prostate and Lung Cancers
2016 Kayvan Samimi Dr. Tomy Varghese Quantitative Ultrasound Imaging During Ablation Procedures
2015 David Niles Dr. Sean Fain MRI Biomarkers for Renal Function and Disease
2015 Peter Scully Dr. Robert Jeraj Imaging Biomarkers of Treatment Response: Applications to Clinical Trials
2015 Karissa Tilbury Dr. Paul Campagnola Second Harmonic Generation Imaging of Ovarian Cancer
2015 You Ming Yang Dr. Bryan Bednarz Concurrent Monte Carlo Transport and Fluence Optimization Theory, Development and Applications
2014 Jeremy Bredfeldt Dr. Thomas Mackie Collagen Alignment Imaging and Analysis for Breast Cancer Classification
2014 Ansel Hillmer Dr. Bradley Christian Imaging α4β2 Nicotinic Acetylcholine Receptors with [18F]Nifene PET
2014 Nicholas Rubert Dr. Tomy Varghese Quantitative Ultrasound Imaging of Thermal Ablation Therapy in the Liver
2013 Matthew Bayer Dr. Timothy Hall Ultrasonic Motion Tracking for Large Multi-Step Deformations
2013 Andrew Ellis Dr. Wolfgang Tome Effects of Respiratory Motion and Risk-Region Misclassification on Subvolume Boosting in Radiotherapy
2013 Athena Heredia Dr. Douglass Henderson Developing a Directional High-Dose Rate Brachytherapy Source
2013 Timothy Szczykutowicz Dr. Charles Mistretta Fluence field modulated computed tomography: Implemented using digital beam attenuation
2013 Dustin Wooten Dr. Bradley Christian The Development of PET Techniques to Study the 5-HT1A System
2012 Nicholas Bevins Dr. Guang-Hong Chen X-ray Phase Contrast Imaging: Evaluating Clinical Utility
2012 Eric Bultman Dr. Scott Reeder Quantitative MR imaging: Applications to chronic liver disease and hepatocellular carcinoma
2012 John Floberg Dr. Charles Mistretta Novel Denoising methods for Dynamic Positron Emission Tomography
2012 Regina Fulkerson Dr. Larry DeWerd Dosimetric characterization of surface applicators for use with high dose rate 192Ir and electronic brachytherapy sources